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List of works by Terry J. Smith

A novel ELISpot method for adherent cells

scientific article published on 01 August 2004

A population-based prospective study of optic neuritis

scientific article published on October 2017

Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression. Insights into potential pathogenic mechanisms of thyroid-associated ophth

scientific article published on 01 November 1998

Advances in understanding autoimmune pituitary disease: standardized methods for autoantibody detection

scientific article

Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts

scientific article published on 01 December 1998

B cell depletion in Graves' disease: the right answer to the wrong question?

scientific article published on 01 May 2007

Bidimensional gel electrophoretic analysis of protein synthesis and response to interferon-gamma in cultured human dermal fibroblasts

scientific article published on 01 June 1993

Building the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy.

scientific article published on January 2016

CD34- Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy Modulate TNF-α Expression in CD34+ Fibroblasts and Fibrocytes.

scientific article

CD40 Expression in Fibrocytes Is Induced by TSH: Potential Synergistic Immune Activation

scientific article

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study

article

Challenges in Orphan Drug Development: Identification of Effective Therapy for Thyroid-Associated Ophthalmopathy

article

Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis

scientific article published on 27 May 2015

Characterization of the anaemia associated with Graves' disease

scientific article published on 15 August 2008

Circulating mononuclear cells from euthyroid patients with thyroid-associated ophthalmopathy exhibit characteristic phenotypes.

scientific article published in April 2007

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

scientific article published on 28 June 2019

Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.

scientific article

Current perspective on the pathogenesis of Graves' disease and ophthalmopathy.

scientific article published on December 2003

Cyclooxygenases as the principal targets for the actions of NSAIDs

scientific article published on 01 August 1998

Cytokine-induced lymphocyte chemoattraction from cultured human thyrocytes: evidence for interleukin-16 and regulated upon activation, normal T cell expressed, and secreted expression

scientific article published on 01 July 2003

Cytokines are both villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside.

scientific article

Cytokines, Graves' disease, and thyroid-associated ophthalmopathy

scientific article

Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production.

scientific article

Development of criteria for evaluating clinical response in thyroid eye disease using a modified Delphi technique

scientific article

Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease.

scientific article

Divergent expression of IL-1 receptor antagonists in CD34⁺ fibrocytes and orbital fibroblasts in thyroid-associated ophthalmopathy: contribution of fibrocytes to orbital inflammation

scientific article published on 30 April 2013

Evidence of adipocyte differentiation in human orbital fibroblasts in primary culture

scientific article published on 01 September 1996

Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE.

scientific article

Fibroblasts as sentinel cells: role of the CDcd40-CDcd40 ligand system in fibroblast activation and lung inflammation and fibrosis

scientific article published in July 2001

Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease.

scientific article published on 28 September 2011

Glucocorticoid regulation of glycosaminoglycan synthesis in cultured human skin fibroblasts: evidence for a receptor-mediated mechanism involving effects on specific de novo protein synthesis

scientific article published on 01 February 1988

Glucocorticoids enhance glucose uptake and affect differentiation and beta-adrenergic responsiveness in muscle cell cultures ⬇️

scientific article published on March 1, 1981

Graves' Disease

scientific article published on 01 January 2017

Graves' Disease.

scientific article

HIF2A-LOX pathway promotes fibrotic tissue remodeling in thyroid-associated orbitopathy

scientific article published on 01 January 2019

Histopathology of brow fat in thyroid-associated orbitopathy.

scientific article published in January 2012

Human fibrocytes coexpress thyroglobulin and thyrotropin receptor ⬇️

scientific article published on April 19, 2012

Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases

scientific article

Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts.

scientific article

IGF-I receptor and thyroid-associated ophthalmopathy

scientific article published on 22 December 2017

Immune mechanisms in thyroid eye disease.

scientific article published on September 2008

Immunoglobulin G from patients with Graves' disease induces interleukin-16 and RANTES expression in cultured human thyrocytes: a putative mechanism for T-cell infiltration of the thyroid in autoimmune disease.

scientific article published on 12 January 2006

Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor.

scientific article published in October 2004

Immunopathogenesis of thyroid eye disease: emerging paradigms

scientific article

Inclusion of brain volume loss in a revised measure of 'no evidence of disease activity' (NEDA-4) in relapsing-remitting multiple sclerosis

scientific article published on 19 November 2015

Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production.

scientific article published on 7 March 2012

Increased generation of fibrocytes in thyroid-associated ophthalmopathy

scientific article

Induction of heme oxygenase mRNA by cobalt protoporphyrin in rat liver

scientific article published on 01 January 1991

Insights into the role of fibroblasts in human autoimmune diseases.

scientific article

Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy

scientific article published on 01 February 2019

Integrative continuum: accelerating therapeutic advances in rare autoimmune diseases

scientific article published on January 2012

Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.

scientific article published in 2006

Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB.

scientific article

Is IGF-I receptor a target for autoantibody generation in Graves' disease?

scientific article published in February 2013

Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions.

scientific article

Magnetic resonance imaging findings at the first episode of acute optic neuritis

scientific article published on 25 December 2017

Molecular Cloning and Characterization of the Human and Mouse UDP-Glucose Dehydrogenase Genes ⬇️

scientific article published on September 25, 1998

Molecular pathology of Muller's muscle in Graves' ophthalmopathy.

scientific article

Neuromyelitis optica spectrum disorder: Patient experience and quality of life

scientific article published on 20 June 2019

New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor.

scientific article

Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1.

scientific article published on 30 December 2008

PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: implications to thyroid-associated ophthalmopathy

scientific article

PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: modulation by PTEN

scientific article

Pharmacotherapy: does selenium supplementation improve Graves ophthalmopathy?

scientific article published on 02 August 2011

Pleotrophic action of interferon gamma in human orbital fibroblasts

scientific article published on 01 March 1993

Potential Roles of CD34+ Fibrocytes Masquerading as Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy

scientific article published on 01 February 2019

Potential role for bone marrow-derived fibrocytes in the orbital fibroblast heterogeneity associated with thyroid-associated ophthalmopathy.

scientific article published on 19 August 2010

Prostaglandin E2 elicits a morphological change in cultured orbital fibroblasts from patients with Graves ophthalmopathy

scientific article

Prostaglandin-endoperoxide H synthase-2 expression in human thyroid epithelium. Evidence for constitutive expression in vivo and in cultured KAT-50 cells.

scientific article published on May 1999

Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy

scientific article published on October 2008

Regulation by glucocorticoids of interferon gamma-induced HLA-DR antigen expression in cultured human orbital fibroblasts

scientific article published on 01 July 1992

Regulation of IL-1 receptor antagonist by TSH in fibrocytes and orbital fibroblasts.

scientific article published on 21 January 2014

Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation

scientific article published on January 2008

Response to Krieger et al. re: "TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis" (Thyroid 2017;27:746-747)

scientific article published on 28 September 2017

Response to Letter to the Editor: "Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy"

scientific article published on 01 April 2019

Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine

scientific article published on 01 July 1989

Retinoic acid can enhance the stimulation by thyroid hormone of heme oxygenase activity in the liver of thyroidectomized rats

scientific article published on 01 October 1991

Retinoic acid inhibition of thyroxine binding to human transthyretin

scientific article published on 01 January 1994

Rituximab (Rituxan) therapy for severe thyroid-associated ophthalmopathy diminishes IGF-1R(+) T cells

scientific article

Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy

scientific article

Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy.

scientific article published on June 2012

Rosiglitazone-induced proptosis.

scientific article published in January 2005

Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes

scientific article published on 21 February 2020

Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease.

scientific article published on 11 May 2018

T helper type 1 and type 2 cytokines exert divergent influence on the induction of prostaglandin E2 and hyaluronan synthesis by interleukin-1beta in orbital fibroblasts: implications for the pathogenesis of thyroid-associated ophthalmopathy.

scientific article published on 6 October 2005

TSH-receptor-expressing fibrocytes and thyroid-associated ophthalmopathy

scientific article

TSHR as a therapeutic target in Graves' disease

scientific article published on 27 January 2017

Targeted biological therapies for Graves' disease and thyroid-associated ophthalmopathy. Focus on B-cell depletion with Rituximab

scientific article

Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes.

scientific article

Teprotumumab: a novel therapeutic monoclonal antibody for thyroid-associated ophthalmopathy

scientific article published on 19 May 2020

The consequences of inappropriate treatment because of failure to recognize the syndrome of pituitary and peripheral tissue resistance to thyroid hormone

scientific article

The insulin-like growth factor-I receptor and its role in thyroid-associated ophthalmopathy

scientific article published on 01 November 2018

The putative role of fibroblasts in the pathogenesis of Graves' disease: evidence for the involvement of the insulin-like growth factor-1 receptor in fibroblast activation.

scientific article published on September 2003

Thyroid Eye Disease: Towards an Evidence Base for Treatment in the 21st Century ⬇️

scientific article published on June 1, 2012

Thyrotropin regulates IL-6 expression in CD34+ fibrocytes: clear delineation of its cAMP-independent actions.

scientific article published on 25 September 2013

Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis

scientific article published in January 2010

Treating the thyroid in the presence of Graves' ophthalmopathy.

scientific article published on June 2012

Ultrastructural features of osmotic shock in mussel gill cilia ⬇️

scientific article published on July 1, 1977

Ultrastructure of cultured human orbital fibroblasts

scientific article published on 01 December 1994

Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.

scientific article published on September 2008

Will biological agents supplant systemic glucocorticoids as the first-line treatment for thyroid-associated ophthalmopathy?

scientific article published on 01 November 2019

n-Butyrate increases c-erb A oncogene expression in human colon fibroblasts

scientific article published on 01 January 1988

n-Butyrate induces plasminogen activator inhibitor type 1 messenger RNA in cultured Hep G2 cells

scientific article published on 01 April 1996

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