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List of works by Santos A. Susin

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

scientific article published in August 2001

AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes.

scientific article published on 11 January 2018

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.

scientific article published on 13 September 2012

AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics.

scientific article published on 24 March 2011

AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer.

scientific article published on 19 December 2005

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

scientific article published in Journal of Biological Chemistry

Annonaceous acetogenins: the hydroxyl groups and THF rings are crucial structural elements for targeting the mitochondria, demonstration with the synthesis of fluorescent squamocin analogues.

scientific article published in June 2005

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

scientific article

Apoptosis inversely correlates with rabies virus neurotropism.

scientific article published on December 2003

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

scientific article published on May 1996

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

scientific article (publication date: 7 July 2000)

Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus

scientific article

Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore

scientific article published on 01 June 1999

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.

scientific article published on 8 July 2011

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

scientific article

Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells

scientific article published on 01 December 2000

CD47 agonist peptide PKHB1 induces immunogenic cell death in T-cell acute lymphoblastic leukemia cells

scientific article published on 14 December 2018

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans

scientific article

CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling

scientific article published on October 2008

CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors

scientific article published on 28 March 2012

CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice.

scientific article

Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult.

scientific article published in August 2000

Caspase-independent type III PCD: a new means to modulate cell death in chronic lymphocytic leukemia

scientific article

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

scientific article published on 10 March 2009

Caspases disrupt mitochondrial membrane barrier function.

scientific article published in May 1998

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

scientific article published in March 2001

Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis.

scientific article published in December 1996

Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease.

scientific article

Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release

scientific article published in November 2005

Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes

scientific article published in April 1998

Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells.

scientific article

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition.

scientific article published in April 1998

Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor

article by MARKUS LOEFFLER et al published March 2001 in FASEB Journal

Drp1 mediates caspase-independent type III cell death in normal and leukemic cells

scientific article published on 6 August 2007

Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and cytocidal potential

scientific article published on 01 January 1996

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

scientific article (publication date: 29 March 2001)

Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease

scientific article published on 28 February 2006

Expression of dengue ApoptoM sequence results in disruption of mitochondrial potential and caspase activation.

scientific article published on August 2003

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1.

scientific article

Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia

scientific article published on 07 May 2019

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

scientific article published on 01 November 2019

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

scientific article published in May 1997

High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection.

scientific article published on September 2003

Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: new putative biological targets of squamocin detected by activity-based protein profiling.

scientific article

Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

scientific article published on 26 August 2019

Hsp27 negatively regulates cell death by interacting with cytochrome c.

scientific article

Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity

scientific article published on 27 April 2006

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.

scientific article published in April 1996

Involvement of apoptosis-inducing factor during dolichyl monophosphate-induced apoptosis in U937 cells

scientific article published on 01 September 2000

Key Residues Regulating the Reductase Activity of the Human Mitochondrial Apoptosis Inducing Factor.

scientific article published on 3 August 2015

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

article

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

scientific article published on February 2000

Mitochondria and programmed cell death: back to the future.

scientific article published on October 1996

Mitochondria as regulators of apoptosis: doubt no more.

scientific article published in August 1998

Mitochondrial OXPHOS influences immune cell fate: lessons from hematopoietic AIF-deficient and NDUFS4-deficient mouse models.

scientific article

Mitochondrial control of apoptosis

scientific article published on January 1997

Mitochondrial control of nuclear apoptosis.

scientific article

Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release

scientific article published in August 2003

Mitochondrial effectors in caspase-independent cell death

scientific article published on January 2004

Mitochondrial permeability transition in apoptosis and necrosis

scientific article published on March 1998

Mitochondrial permeability transition triggers lymphocyte apoptosis.

scientific article published in December 1996

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

scientific article (publication date: April 2000)

Molecular characterization of mitochondrial apoptosis-inducing factor

scientific article

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells

scientific article published on 01 October 1998

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition.

scientific article published in June 1997

PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

scientific article published in June 1998

Palmitate induces apoptosis via a direct effect on mitochondria.

scientific article published in April 1999

Programmed cell death via mitochondria: different modes of dying.

scientific article

Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function.

scientific article published in January 1997

Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress

scientific article published in May 2006

Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia

scientific article published on 31 July 2020

Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo

scientific article

Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?

article published in 2018

Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: selection and study of a benzoquinone hybrid with an improved biological profile.

scientific article

Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.

scientific article published on 30 April 2007

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death ⬇️

scientific article published on August 1, 1995

Simplification of complex peptide mixtures for proteomic analysis: reversible biotinylation of cysteinyl peptides

scientific article published in May 2000

Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor

scientific article

Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1-derived peptides overcomes drug resistance

scientific article published on 01 October 2019

The crystal structure of the mouse apoptosis-inducing factor AIF

scientific article

The oxido-reductase activity of the apoptosis inducing factor: a promising pharmacological tool?

scientific article published on January 2013

Therapeutic potential of AIF-mediated caspase-independent programmed cell death.

scientific article published on December 2007

Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

scientific article published on 15 August 2016

Use of penetrating peptides interacting with PP1/PP2A proteins as a general approach for a drug phosphatase technology.

scientific article published on 30 December 2005

[Programmed cell death comes in many flavors].

scientific article published on 20 December 2013

“Double-hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain

scientific article published on 18 December 2017

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