List of works - Viola Oorschot

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

scientific article

AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes

scientific article

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium

scientific article

Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

scientific article

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

scientific article published in February 2018

Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes

scientific article

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth

scientific article published on 23 December 2015

Constitutive formation of caveolae in a bacterium

scientific article published on August 2012

Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections

scientific article

Cripto localizes Nodal at the limiting membrane of early endosomes

scientific article

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

scientific article

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms

scientific article

Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis

scientific article published on 5 May 2011

FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency

scientific article published on 11 March 2016

Glycosylation Is Important for Cell Surface Expression of the Water Channel Aquaporin-2 but Is Not Essential for Tetramerization in the Endoplasmic Reticulum ⬇️

scientific article published on October 30, 2003

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport

scientific article published on 9 May 2012

Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O.

scientific article

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure

scientific article published on 24 January 2007

Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination

scientific article published on 06 May 2019

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

scientific article

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery

scientific article published on 11 August 2014

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells

scientific article published on 30 May 2011

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis

scientific article

Metformin rescues muscle function in BAG3 myofibrillar myopathy models

scientific article published on 08 October 2020

Modern approaches for ultrastructural analysis of the zebrafish embryo

scientific article

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

scientific article

Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes

scientific journal article

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

scientific journal article

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

scientific article published on August 2003

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed

scientific journal article

Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle

scientific article

Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes

scientific article

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides

scientific article published on 8 May 2007

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel

scientific article (publication date: 28 November 2006)

Sorting nexin 17 facilitates LRP recycling in the early endosome

scientific article

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

scientific article

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport

scientific article

Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity

scientific article published on 21 June 2010

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance

scientific article

Termination of autophagy and reformation of lysosomes regulated by mTOR

scientific article

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion

scientific article

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)

scientific article

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes

scientific article published on 16 February 2011

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins

scientific article

mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles

scientific article published on 05 August 2009

List of works by Viola Oorschot

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium

Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth

Constitutive formation of caveolae in a bacterium

Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections

Cripto localizes Nodal at the limiting membrane of early endosomes

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms

Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis

FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency

Glycosylation Is Important for Cell Surface Expression of the Water Channel Aquaporin-2 but Is Not Essential for Tetramerization in the Endoplasmic Reticulum ⬇️

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport

Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O.

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure

Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis

Metformin rescues muscle function in BAG3 myofibrillar myopathy models

Modern approaches for ultrastructural analysis of the zebrafish embryo

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed

Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle

Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel

Sorting nexin 17 facilitates LRP recycling in the early endosome

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport

Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance

Termination of autophagy and reformation of lysosomes regulated by mTOR

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins

mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles