Search filters

List of works by Yehuda G Assaraf

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.

scientific article published on 8 January 2009

Alteration of mitochondrial gene expression and disruption of respiratory function by the lipophilic antifolate pyrimethamine in mammalian cells

scientific article published in September 1995

Alterations in ZnT1 expression and function lead to impaired intracellular zinc homeostasis in cancer

scientific article published on 12 November 2019

Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.

scientific article

Beta-casein nanovehicles for oral delivery of chemotherapeutic drugs.

scientific article published on 16 July 2009

C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.

scientific article published on April 2007

Cancer cell-selective, clathrin-mediated endocytosis of aptamer decorated nanoparticles.

scientific article published on 20 April 2018

Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets

scientific article

Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter

scientific article published on 2 November 2018

Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family.

scientific article published on November 2003

Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.

scientific article published on 4 July 2016

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance

scientific article published on 6 November 2015

Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis

scientific article published on 01 February 1996

Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.

scientific article

Heterodimerization, altered subcellular localization, and function of multiple zinc transporters in viable cells using bimolecular fluorescence complementation

scientific article published on 5 February 2015

Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance

scientific article

High proportion of transient neonatal zinc deficiency causing alleles in the general population

scientific article published on 18 November 2018

Increased Activity of a Novel Low pH Folate Transporter Associated with Lipophilic Antifolate Resistance in Chinese Hamster Ovary Cells ⬇️

scientific article published on April 3, 1998

Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells ⬇️

scientific article published on February 8, 2012

Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters

scientific article published on 01 October 1999

Loss of Folic Acid Exporter Function with Markedly Augmented Folate Accumulation in Lipophilic Antifolate-resistant Mammalian Cells ⬇️

scientific article published on July 11, 1997

Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

scientific article

LysoTracker and MitoTracker Red are transport substrates of P-glycoprotein: implications for anticancer drug design evading multidrug resistance

scientific article published on 26 January 2018

Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis

scientific article published on 7 February 2017

Lysosomes as mediators of drug resistance in cancer.

scientific article published on 26 November 2015

Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity

scientific article published on 13 December 2018

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions

scientific article published on 28 November 2018

Modulating ROS to overcome multidrug resistance in cancer

scientific article published on 14 November 2018

Molecular Basis of Transient Neonatal Zinc Deficiency: NOVEL ZnT2 MUTATIONS DISRUPTING ZINC BINDING AND PERMEATION.

scientific article published on 02 May 2016

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

scientific article published in January 2002

Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.

scientific article published on 13 April 2006

Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance

scientific article published in December 2005

PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells.

scientific article published on 24 September 2008

Plasmodium falciparum: purification, properties, and immunochemical study of ornithine decarboxylase, the key enzyme in polyamine biosynthesis

scientific article published on 01 October 1988

Plasmodium falciparum: synchronization of cultures with DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis

scientific article published on 01 April 1986

Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability.

scientific article published in March 1995

Probing ATP-dependent conformational changes in the multidrug resistance protein 1 (MRP1/ABCC1) in live tumor cells with a novel recombinant single-chain Fv antibody targeted to the extracellular N-terminus.

scientific article

Protein-coated corrole nanoparticles for the treatment of prostate cancer cells

scientific article published on 28 July 2020

Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.

scientific article published on 09 October 2003

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

scientific article

Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells.

scientific article

Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools ⬇️

scientific article

Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo

scientific article published on 20 September 2019

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.

scientific article published on 20 February 2014

Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells.

scientific article published on 6 June 2017

Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance

scientific article

Surmounting Cytarabine-resistance in acute myeloblastic leukemia cells and specimens with a synergistic combination of hydroxyurea and azidothymidine

scientific article published on 17 May 2019

The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.

scientific article

The Obligatory Intestinal Folate Transporter PCFT (SLC46A1) Is Regulated by Nuclear Respiratory Factor 1 ⬇️

scientific article published on August 19, 2010

The folate receptor as a rational therapeutic target for personalized cancer treatment

scientific article published on 08 October 2014

The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis

scientific article

The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.

scientific article published on August 2006

The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency.

scientific article published on 30 June 2017

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

scientific article published on 20 March 2019

β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer

scientific article published on 24 October 2018

Paulina is supported by:

About Paulina

Help