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List of works by Cirino Botta

A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.

scientific article published on 2 November 2015

A gene expression inflammatory signature specifically predicts multiple myeloma evolution and patients survival.

scientific article published on 16 December 2016

A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells.

scientific article published in December 2014

A retrospective analysis of pegylated liposomal doxorubicin in ovarian cancer: do we still need it?

scientific article published on 6 February 2013

A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?

scientific article

An in-depth evaluation of acalabrutinib for the treatment of mantle-cell lymphoma

scientific article published on 18 November 2019

Anti-cancer activity of dose-fractioned mPE +/- bevacizumab regimen is paralleled by immune-modulation in advanced squamous NSLC patients.

scientific article published in September 2017

Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients

scientific article

Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation

scientific article published on 23 April 2021

Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro.

scientific article published on 16 August 2011

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

scientific article published on 16 June 2021

Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility

scientific article published on 17 February 2021

Early blood rise in auto-antibodies to nuclear and smooth muscle antigens is predictive of prolonged survival and autoimmunity in metastatic-non-small cell lung cancer patients treated with PD-1 immune-check point blockade by nivolumab

scientific article published on 16 May 2019

Elotuzumab, lenalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: Italian, multicenter, retrospective clinical experience with 300 cases outside of controlled clinical trials

scientific article published on 27 February 2020

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up

scientific article published on 08 November 2019

Gemcitabine, oxaliplatin, levofolinate, 5-fluorouracil, granulocyte-macrophage colony-stimulating factor, and interleukin-2 (GOLFIG) versus FOLFOX chemotherapy in metastatic colorectal cancer patients: the GOLFIG-2 multicentric open-label randomized

scientific article published on January 2014

Identification of polymorphic variants associated with erlotinib-related skin toxicity in advanced non-small cell lung cancer patients by DMET microarray analysis.

scientific article published on 25 November 2015

Immune-modulating effects of bevacizumab in metastatic non-small-cell lung cancer patients.

scientific article published on 3 October 2016

Immune-modulating effects of the newest cetuximab-based chemoimmunotherapy regimen in advanced colorectal cancer patients.

scientific article published on June 2012

Immunologic microenvironment and personalized treatment in multiple myeloma.

scientific article published on 22 May 2013

Immunomodulatory activity of microRNAs: potential implications for multiple myeloma treatment

scientific article published on 30 March 2017

Immunotherapy of colorectal cancer: new perspectives after a long path.

scientific article published on November 2016

In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection

scientific article published on 04 May 2022

Inflammatory status affects the antitumor activity of poly-epitope-peptide vaccination against the thymidylate synthase in metastatic colo-rectal cancer patients enrolled in TSPP/VAC-1 Phase Ib trial.

scientific article published on 4 November 2015

Influence of the Fabrication Accuracy of Hot-Embossed PCL Scaffolds on Cell Growths

scientific article published on 14 February 2020

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

scientific article published on 24 June 2015

Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response

scientific article published in 2021

Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation

scientific article

MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells

scientific article published on 21 November 2017

Mouse models of multiple myeloma: technologic platforms and perspectives.

scientific article

Myeloid-derived suppressor cells in multiple myeloma: pre-clinical research and translational opportunities

scientific article published on 08 December 2014

Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients

scientific article published on 27 February 2017

OSAnalyzer: A Bioinformatics Tool for the Analysis of Gene Polymorphisms Enriched with Clinical Outcomes

scientific article published on 23 September 2016

Pegylated liposomal doxorubicin in the management of ovarian cancer: a systematic review and metaanalysis of randomized trials

scientific article

Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients.

scientific article published on 2 June 2015

Phase II trial of bevacizumab and dose/dense chemotherapy with cisplatin and metronomic daily oral etoposide in advanced non-small-cell-lung cancer patients

scientific article

Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients.

scientific article published on 21 December 2015

Radiomics predicts survival of patients with advanced non-small cell lung cancer undergoing PD-1 blockade using Nivolumab

scientific article published on 16 December 2019

Radiotherapy prolongs the survival of advanced non-small-cell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev).

scientific article published on 24 August 2017

Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma

scientific article published on 18 February 2019

Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials

scientific article

Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo.

scientific article

Survival risk score for real-life relapsed/refractory chronic lymphocytic leukemia patients receiving ibrutinib. A campus CLL study

scientific article published on 14 April 2020

Systematic review and meta-analysis on targeted therapy in advanced pancreatic cancer

scientific article published on 20 January 2016

Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine.

scientific article

The best strategy for RAS wild-type metastatic colorectal cancer patients in first-line treatment: A classic and Bayesian meta-analysis

scientific article published on 9 March 2018

The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.

scientific article published on 4 May 2018

The route to solve the interplay between inflammation, angiogenesis and anti-cancer immune response.

scientific article published on 21 July 2016

Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma

scientific article published on 21 March 2019

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination

scientific article published on 08 October 2019

Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse

scientific article published on 28 October 2016

Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma

scientific article published on 05 December 2011

miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma

scientific article published on 06 July 2020

miR-22 suppresses DNA ligase III addiction in multiple myeloma

scientific article published on 17 August 2018

miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease

scientific article published on July 2013

miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies.

scientific article published on 12 April 2015

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