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List of works by Andreas Trumpp

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

scientific article published on 17 January 2018

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS -Mutant Cancer

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

scientific article

A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition

scientific article

AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress.

scientific article published on 12 February 2018

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

scientific article published on 17 July 2019

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

scientific article published on 23 January 2017

Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition

scholarly article

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations

scientific article published on 07 August 2020

Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin

scientific article published on 15 October 2020

An Intrinsic Interferon Program Protects Stem Cells from Viral Infection

scientific article published on 5 February 2018

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

scientific article

Analysis of non-leukemic cellular subcompartments reconstructs clonal evolution of acute myeloid leukemia and identifies therapy-resistant pre-leukemic clones

scientific article published on 07 January 2021

Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

scientific article published on 16 May 2018

Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDH-like DNA hypermethylation

scientific article published in Nature

Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

scientific article published in Nature

Awakening dormant haematopoietic stem cells

article by Andreas Trumpp et al published March 2010 in Nature Reviews Immunology

Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer

scientific article published in 2022

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

scientific article published on 8 November 2017

Balancing dormant and self-renewing hematopoietic stem cells

scientific article published on 05 October 2009

Bone-marrow haematopoietic-stem-cell niches

scientific article

Breaking the cell cycle of HSCs by p57 and friends

scientific article published on September 2011

Bridging the information gap

Büroflächenleerstand in Berlin

C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia

scientific article

CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma.

scientific article

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

scientific article published on 8 February 2016

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

scientific article published in May 2018

Challenges and opportunities of CYP3A5 as novel drug target in pancreatic cancer subtypes

Circulating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer

scientific article published on 16 January 2018

Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer

scientific article

Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis

scientific article published on 19 January 2016

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients

scientific article

Colonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System

scientific article published on 01 January 2003

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

scientific article published on 23 December 2019

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

scientific article

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc

scientific article published on May 2012

Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification

scientific article published on 16 December 2015

Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway

scientific journal article

Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF?p53 pathway.

scientific article published in January 2009

Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

scientific article

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch

scientific article

Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin

scientific article published on 19 February 2015

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

scientific article published on 13 December 2018

Development and characteristics of preclinical experimental models for the research of rare neuroendocrine bladder cancer

scientific article published on 29 June 2013

Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells

scientific article

Developmental vascular regression is regulated by a Wnt/β-catenin, MYC, P21 (CDKN1A) pathway that controls cell proliferation and cell death.

scientific article

Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism

scientific article published on 30 March 2020

Dormant and self-renewing hematopoietic stem cells and their niches

scientific article published on 18 April 2007

Endothelial Notch1 Activity Facilitates Metastasis

scientific article published on 12 February 2017

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

scientific article published on 28 June 2010

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

scientific article

Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics

scientific article

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

scientific article published on 18 February 2015

Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy

scientific article published on 12 March 2014

Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts.

scientific article published on 22 August 2011

HER2-targeted therapy influences CTC status in metastatic breast cancer

scientific article published on 20 May 2020

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

scientific article published on 04 November 2019

Hematopoietic Stem Cell Niches

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

article

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

scientific article published on December 2008

Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway

scientific article

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

scientific article

High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chemotherapy: A retrospective cohort study

scientific article published on 22 April 2017

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

scientific article

Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem/Progenitor Cell Pool

scientific article published on 30 October 2009

Human haematopoietic stem cell lineage commitment is a continuous process

scientific article

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

IFNalpha activates dormant haematopoietic stem cells in vivo.

scientific article published on 11 February 2009

Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma.

scientific article published on 11 November 2016

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing

scientific article

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells

scholarly article by Marc Christian Thier et al published 3 January 2019 in Cell Stem Cell

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

scientific article published on 21 April 2013

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma

scientific article

Identification of evolutionarily conserved regulatory elements in the mouse Fgf8 locus

article

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

scientific article published on 01 March 2021

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

scientific article published on 21 August 2014

Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer.

scientific article published in October 2016

Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.

scientific article

In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice.

scientific article published on 23 July 2009

Inducible gene and shRNA expression in resident hematopoietic stem cells in vivo

scientific article published on August 2010

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

scientific article published on 19 August 2015

Innovations, challenges, and minimal information for standardization of humanized mice

scientific article published on 24 June 2020

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model

scientific article published on 4 October 2013

Ion source-dependent performance of 4-vinylpyridine, iodoacetamide, and N-maleoyl derivatives for the detection of cysteine-containing peptides in complex proteomics.

scientific article published on 22 October 2015

Label retaining cells in cancer--the dormant root of evil?

scientific article published on 23 April 2013

Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML

article

Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease

scientific article

Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence

article

MALDI versus ESI: The Impact of the Ion Source on Peptide Identification.

scientific article

Mechanisms of Disease: cancer stem cells--targeting the evil twin

scientific article published on 22 April 2008

Metabolic cues for hematopoietic stem cells.

scientific article published in December 2016

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

scientific article published on 20 March 2020

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

scientific article published on 01 May 2005

More than just proliferation: Myc function in stem cells

article by Mark J. Murphy et al published March 2005 in Trends in Cell Biology

Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells

scientific article

MutaSeq reveals the transcriptomic consequences of clonal evolution in acute myeloid leukemia

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

scientific article

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

scientific article published on February 2016

Myc's other life: stem cells and beyond

scientific article published on 14 October 2009

Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal

scientific article published on December 2016

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit

scientific article published on 3 April 2014

N-myc controls proliferation, morphogenesis, and patterning of the inner ear

scientific article

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

scientific article published in November 2001

Nestin expression in pancreatic exocrine cell lineages.

scientific article published in January 2004

Nestin-Cre mediated deletion of Pitx2 in the mouse

scientific article published in July 2006

Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues

scholarly article by Nicole C. Dubois et al published 17 July 2006 in Genesis

Neurotrophin-3 is required for proper cerebellar development

scientific journal article

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

scientific article published on 27 January 2021

OMIP-059: Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel

scientific article published on 07 July 2019

Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response

scientific article published on 3 November 2017

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

scientific article published on 09 October 2008

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

scientific article published on 25 April 2022

Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function

scientific article published on 11 June 2008

Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis

scientific article published on 17 May 2014

Plasma S100P level as a novel prognostic marker of metastatic breast cancer

scientific article

Plasma hyaluronic acid level as a prognostic and monitoring marker of metastatic breast cancer

scientific article published on 19 December 2015

Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response

scientific journal article

Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells

scientific article

Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization

scientific article published on 14 October 2013

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

scientific article published on 01 August 2019

Quantitative proteomics reveals specific metabolic features of Acute Myeloid Leukemia stem cells

scientific article published on 18 June 2020

Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia

scientific article published on 26 May 2017

Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications

scientific article published on 11 March 2009

STEM CELLS. Potency finds its niches

scientific article

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

scientific article published on 19 January 2018

Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations.

scientific article published on 27 November 2017

Selection and dynamics of embryonic stem cell integration into early mouse embryos

scientific article published on 19 November 2015

Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development

scientific article published in April 2009

Senescence-associated reprogramming promotes cancer stemness.

scientific article published on 20 December 2017

Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients

scientific article

Single cell polarity in liquid phase facilitates tumour metastasis.

scientific article published on 28 February 2018

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

scientific article published on 18 June 2018

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

scientific article published on 19 March 2021

Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene

scientific article

Stem cells make leukemia grow again

scientific article published on 21 August 2017

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.

scientific article

Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients

scientific article published on 29 July 2020

Survival of pancreatic cancer cells lacking KRAS function.

scientific article

Sustained prognostic impact of circulating tumor cell status and kinetics upon further progression of metastatic breast cancer

scientific article published on 01 October 2018

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

scientific article published on June 2017

Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells

scientific article published on 14 May 2019

Targeting leukemic stem cells by breaking their dormancy

scientific article published on 09 June 2010

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

scientific article published on 07 May 2007

The Myc trilogy: lord of RNA polymerases

scientific article published in March 2005

The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in.

scientific article published on March 2011

The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis

scientific article

The evolving concept of cancer and metastasis stem cells

scientific article

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a retrospective study in 107 patients

scientific article published on 14 May 2015

The impact of type 2 diabetes on the outcome of localized renal cell carcinoma

scientific article published on 27 December 2013

The influence of prostatic anatomy and neurotrophins on basal prostate epithelial progenitor cells

scientific article published on 7 October 2015

The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells

scientific article published in Scientific Reports

The molecular signature of AML with increased ALDH activity suggests a stem cell origin

scientific article published on 16 January 2018

The pivotal role of reactivity in the design of novel biotinylation reagents for the chemical-proteomics-based identification of vascular accessible biomarkers

article published in 2016

The prognostic impact of circulating tumor cells in subtypes of metastatic breast cancer

scientific article published on 28 December 2012

The protooncogene MYC can break B cell tolerance

scientific article

The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients

scientific article published on 14 January 2015

The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features

scientific article

Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations

scientific article published on 26 April 2012

Toward modeling the bone marrow niche using scaffold-based 3D culture systems

article

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

scientific article published on 24 November 2015

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

scientific article

Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment

scientific article

Tuning mTORC1 Activity for Balanced Self-Renewal and Differentiation

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas

scientific journal article

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

scientific article published on 3 May 2017

What does the concept of the stem cell niche really mean today?

scientific article

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand

scientific article published on 01 November 2018

c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis

scientific article published on 31 January 2006

c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland

scientific article published on 28 September 2009

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

scientific article

c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival

scientific article published on 22 March 2010

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium

scientific article

c-Myc regulates mammalian body size by controlling cell number but not cell size

scientific article published in December 2001

c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo

scientific article

miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells

scientific article published in February 2016

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