List of works - Lore Becker

"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?

scientific article published in May 2008

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice

scientific article

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

scientific article

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

scientific article published on 14 February 2020

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

scientific article (publication date: 29 May 2009)

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

article

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

scientific article

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments

scientific article

Analysis of locomotor behavior in the German Mouse Clinic

scientific article published on 05 May 2017

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods

scientific article published on October 2010

Claudin-12 is not required for blood-brain barrier tight junction function

scientific article published on 12 September 2019

Creatine improves health and survival of mice

scientific article

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

scientific article

DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments

scientific article

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

scientific article published on 03 May 2022

Disease-specific human glycine receptor alpha1 subunit causes hyperekplexia phenotype and impaired glycine- and GABA(A)-receptor transmission in transgenic mice.

scientific article

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

scientific journal article

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

scientific journal article

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

scientific article

Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice

scientific article published on 10 July 2017

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

scientific article

Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review.

scientific article published on 22 May 2018

Genes Whose Gain or Loss-of-Function Increases Endurance Performance in Mice: A Systematic Literature Review

article

Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain

scientific journal article

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

scientific article

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria

scientific article published on 23 November 2019

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 04 November 2020

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.

scientific article

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

scientific article

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

scientific article published in September 2006

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

scientific article

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

scientific article published on 18 January 2016

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

scientific article published on 11 June 2019

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation

scientific article published on 4 June 2015

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention

scientific article

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy

scientific article

Measuring and Interpreting Oxygen Consumption Rates in Whole Fly Head Segments

scientific article published on 07 January 2019

Meis1: effects on motor phenotypes and the sensorimotor system in mice

scientific article published on 23 June 2017

MiR-34a deficiency accelerates medulloblastoma formation in vivo

scientific article

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

scientific article published on 28 December 2020

Mouse phenotyping

scientific article

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

scientific article

Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import

article

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

scientific article published on 06 September 2009

Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord

scientific article published on 16 August 2018

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. ⬇️

scientific article published in July 2009

Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing

scientific article

Pleiotropic effects in Eya3 knockout mice

scientific article

Pleiotropic functions for transcription factor zscan10.

scientific article

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration

scientific article

Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.

scientific article published in March 2004

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 22 December 2020

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.

scientific article

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

scientific article

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

scientific article published on 18 March 2013

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

scientific article published on 2 December 2016

Soft windowing application to improve analysis of high-throughput phenotyping data

scientific article published on 01 March 2020

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

scientific article published on 13 April 2017

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

scientific article published on 20 July 2012

Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

scientific article

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice

scientific article

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

scientific article published on 17 August 2017

Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic

scientific article published on 23 May 2006

Systemic first-line phenotyping

scientific article published on January 2009

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing

scientific article published on 11 September 2017

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

scientific article

The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour

scientific journal article

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

scientific article published on 26 March 2020

Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor beta-subunit: an animal model of startle disease

scientific article

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

scientific article

Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation

scientific article

List of works by Lore Becker

"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments

Analysis of locomotor behavior in the German Mouse Clinic

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods

Claudin-12 is not required for blood-brain barrier tight junction function

Creatine improves health and survival of mice

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

Disease-specific human glycine receptor alpha1 subunit causes hyperekplexia phenotype and impaired glycine- and GABA(A)-receptor transmission in transgenic mice.

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review.

Genes Whose Gain or Loss-of-Function Increases Endurance Performance in Mice: A Systematic Literature Review

Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Innovations in phenotyping of mouse models in the German Mouse Clinic

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy

Measuring and Interpreting Oxygen Consumption Rates in Whole Fly Head Segments

Meis1: effects on motor phenotypes and the sensorimotor system in mice

MiR-34a deficiency accelerates medulloblastoma formation in vivo

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Mouse Genetics and Metabolic Mouse Phenotyping

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Mouse phenotyping

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. ⬇️

Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing

Pleiotropic effects in Eya3 knockout mice

Pleiotropic functions for transcription factor zscan10.

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration

Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.

Rapamycin extends murine lifespan but has limited effects on aging

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

Soft windowing application to improve analysis of high-throughput phenotyping data

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic

Systemic first-line phenotyping

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor beta-subunit: an animal model of startle disease

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation