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List of works by Laura Breda

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

scientific article published on 31 March 2012

A preclinical approach for gene therapy of beta-thalassemia.

scientific article published on August 2010

A validated cellular biobank for β-thalassemia

scientific article published on 02 September 2016

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia ⬇️

scientific article published on June 1, 2013

Complexation to Cationic Microspheres of Double-Stranded Peptide Nucleic Acid-DNA Chimeras Exhibiting Decoy Activity

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

scientific article published on 14 May 2008

Decreased hepcidin mRNA expression in thalassemic mice

scientific article published on 01 January 2004

Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations

scientific article published on 9 July 2009

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

scientific article published on 25 August 2006

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

scientific article published on January 2005

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

scientific article published on 12 July 2016

Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles.

scientific article published on 20 January 2004

Gene therapy for hemoglobinopathies: progress and challenges ⬇️

scientific article published on January 19, 2013

Gene therapy in thalassemia and hemoglobinopathies.

scientific article

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

scientific article published on 4 May 2015

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

scientific article

Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations

scientific article

In vivo hematopoietic stem cell modification by mRNA delivery

scientific article published on 27 July 2023

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

scientific article published on 13 February 2007

Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.

scientific article published on 18 January 2014

Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients

scientific article published on November 2009

Reactivation of developmentally silenced globin genes by forced chromatin looping.

scientific article

Recent trends in the gene therapy of β-thalassemia

scientific article

Role of iron in inducing oxidative stress in thalassemia: Can it be prevented by inhibition of absorption and by antioxidants?

scientific article

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

scientific article (publication date: 2012)

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

article

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