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List of works by John T. Heiker

A novel thermoregulatory role for PDE10A in mouse and human adipocytes

scientific article published on 31 May 2016

A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin)

scientific article

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo

scientific article published on 20 September 2017

Access to gram scale amounts of functional globular adiponectin from E. coli inclusion bodies by alkaline-shock solubilization

scientific article published on 10 June 2010

Adiponectin promotes the migration of circulating angiogenic cells through p38-mediated induction of the CXCR4 receptor

scientific article published on 07 June 2012

Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels

scientific article published on 12 June 2013

Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis

scientific article published on 10 January 2016

Atg7 Knockdown Reduces Chemerin Secretion in Murine Adipocytes

scientific article published on 01 November 2019

Basic Residues of β-Sheet A Contribute to Heparin Binding and Activation of Vaspin (Serpin A12).

scientific article published on 9 December 2016

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation

scientific article

C57BL/6JRj mice are protected against diet induced obesity (DIO).

scientific article published on 8 December 2011

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects

scientific article published on 5 April 2011

Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

scientific article published on 01 December 2021

Crystal structure of cleaved vaspin (serpinA12)

scientific article

Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells.

scientific article published on 10 May 2017

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

scientific article published on 03 May 2022

Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1-Deficient Mice

scientific article published on 12 January 2017

Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue

scientific article

Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability.

scientific article

Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains

scientific article published in April 2014

Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.

scientific article published in February 2018

Letter to the Editor regarding Mörkl et al.'s paper: Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women

article

Liver-restricted Repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice

scientific article

Localization of novel adiponectin receptor constructs.

scientific article published on January 2006

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)

scientific article published on 24 April 2020

Molecular Mechanisms of Vaspin Action - From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain

scientific article published on 01 January 2019

Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors.

scientific article published on September 2010

Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice

scientific article published on 06 July 2020

Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity

scientific article published in March 2013

Novel Mutations in the Asparagine Synthetase Gene (ASNS) Associated With Microcephaly.

scientific article published on 13 July 2018

Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling

scientific article

Replication Initiator 1 in Adipose Tissue Function and Human Obesity

scientific article published on January 1, 2013

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation

scientific article published on 29 January 2021

The Effect of FGF21 and Its Genetic Variants on Food and Drug Cravings, Adipokines and Metabolic Traits

scientific article published in 2021

The Effects of Thyroid Hormones on Gene Expression of Acyl-Coenzyme A Thioesterases in Adipose Tissue and Liver of Mice

scientific article

The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial

scientific article published on 23 November 2020

The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue

scientific article published on 13 May 2013

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

scientific article published on 12 December 2016

Thyroid hormones and browning of adipose tissue

scientific article published on 12 January 2017

Vaspin (serpinA12) in obesity, insulin resistance, and inflammation.

scientific article published on 05 March 2014

Vaspin inhibits kallikrein 7 by serpin mechanism

scientific article

Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway

scientific article published on 26 July 2017

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

scientific article published on 5 February 2018

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