List of works - Nadine Jagerovic

15N NMR chemical shifts of NH-pyrazoles in the solid state and in solution at low temperature

19F,31P,1H NMR and X-ray crystallographic studies of (pentafluorophenyl)3−n (4-pyrazol-1-yl-2,3,5,6-tetrafluorophenyl) n=1,2,3 Phosphines

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.

scientific article published on 6 May 2016

A solid-state NMR, X-ray diffraction, and ab initio computational study of hydrogen-bond structure and dynamics of pyrazole-4-carboxylic acid chains.

scientific article published in August 2001

A structural study of pyrazole-1-carboxamides by X-ray crystallography and 13C CPMAS NMR spectroscopy

Advances Towards The Discovery of GPR55 Ligands

scientific article

Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review.

scientific article published on January 2016

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

scientific article

An experimental (NMR) and theoretical (GIAO) study of the tautomerism of benzotriazole in solution

Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally

scientific article

Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats

scientific article

Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles.

scientific article

Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

scientific article

Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.

scientific article

Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives

scientific article published on 29 June 2009

Antitumor Cannabinoid Chemotypes: Structural Insights

scientific article published on 31 May 2019

Aromatic propellenes. Part 1. NMR spectroscopy, X-ray crystal and molecular structure of hexa(3,5-dimethylpyrazol-1-yl)benzene

Benzyl-1,2,4-triazoles as CB 1 Cannabinoid Receptor Ligands: Preparation and In Vitro Pharmacological Evaluation.

scientific article published on 31 March 2016

Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.

scientific article published on 21 March 2016

CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications

scientific article

Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes

article

Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update

scientific article published on 24 May 2016

Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.

scientific article published on May 2008

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

scientific article published on 16 June 2016

Chromenopyrazoles: non-psychoactive and selective CB₁ cannabinoid agonists with peripheral antinociceptive properties

scientific article

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

scientific article published on 20 February 2014

Description of a bivalent cannabinoid ligand with hypophagic properties

scientific article

Determination of the absolute configuration of 1,3,5-triphenyl-4,5-dihydropyrazole enantiomers by a combination of VCD, ECD measurements, and theoretical calculations

Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif

scientific article

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor

scientific article published on 13 August 2020

Dynamic NMR study of the mechanisms of double, triple, and quadruple proton and deuteron transfer in cyclic hydrogen bonded solids of pyrazole derivatives.

scientific article published in September 2004

Efficient syntheses of new classes of regiochemically pure benzoporphyrin derivatives

scientific article published in 1993

Emerging strategies targeting CB2 cannabinoid receptor: Biased agonism and allosterism

scientific article published on 26 July 2018

Exploring the Benzimidazole Ring as a Substitution for Indole in Cannabinoid Allosteric Modulators

Fentanyl and its analogue N-(1-phenylpyrazol-3-yl)-N-[1-(2-phenylethyl)-4-piperidyl]propanamide: 1H- and 13C-NMR spectroscopy, X-ray crystallography, and theoretical calculations

scientific article published in August 2003

Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.

scientific article

Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism

scientific article

Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for mu opioid and I2-imidazoline receptors: synthesis and pharmacological screening.

scientific article published on April 2002

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.

scientific article published on 20 January 2016

Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage

scientific article published on 07 February 2019

Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.

scientific article published in March 2002

Microwave spectra and ab initio calculations of 1-nitropyrazole

Multiple hydrogen bonds and tautomerism in naphthyridine derivatives

article

New Methods for the Synthesis of Cannabidiol Derivatives

scientific article published on 03 July 2017

New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking

scientific article

Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21

scientific article published on 04 February 2013

Novel approaches and current challenges with targeting the endocannabinoid system

scientific article published on 27 April 2020

Photosensitization with derivatives of chlorin p6

scientific article published on 01 April 1995

Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer.

scientific article published on 20 February 2015

Solid-state structure of NH-pyrazolium hydrochlorides and hydrobromides by X-ray crystallography and CPMAS NMR

Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides

scientific article

Structure and Dynamics of 3,5-Di-tert-butylpyrazole Probed by Combined X-ray Crystallography and 15N Solid State NMR

Structure of 3-nitropyrazole in solution and in the solid state

Structure of a 4-nitroso-5-aminopyrazole and its salts: tautomerism, protonation, and E/Z isomerism

scientific article published in November 2003

Syntheses and preliminary in vivo photodynamic efficacy of benzoporphyrin derivatives from phylloerythrin and rhodoporphyrin XV methyl esters and aspartyl amides

Synthesis and molecular structure of 3-(2-benzyloxy-6-hydroxyphenyl)-5-styrylpyrazoles. Reaction of 2-styrylchromones and hydrazine hydrate

Synthesis and molecular structure of new O/N/O ligands: Bis-phenol-pyridine and bis-phenol-pyrazole

Synthesis and opioid activity of new fentanyl analogs.

scientific article published in July 2002

Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites

scientific article published on 23 June 2006

Synthesis of a novel CB2 cannabinoid-porphyrin conjugate based on an antitumor chromenopyrazoledione

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.

scientific article published on 15 July 2015

Synthesis, structure (NMR and mass spectrometry) and conformational analysis of heterocyclic analogues of dibenzo[a,e]cycloocta-1,5-diene: 5,6,12,13-tetrahydrobispyrazolo[1,2-a:1′,2′-e][1,2,5,6]tetraazocinediium dihalides

article published in 1996

Synthetic cannabinoid quinones: preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity.

scientific article published on 2 October 2013

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

scientific article

Tautomerism of hydroxychromenopyrazoles

The search for proton mobility in solid pyrazoles: molecular and crystal structure of 3(5)-phenyl-4-bromo-5(3)-methylpyrazole

article

The structure of the agrochemical fungicidal 4-chloro-3-(3,5-dichlorophenyl)-1H-pyrazole (RPA 406194) and related compounds

Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?

scientific article published on 11 September 2020

Use of the chlorophyll derivative, purpurin-18, for syntheses of sensitizers for use in photodynamic therapy

article

List of works by Nadine Jagerovic

15N NMR chemical shifts of NH-pyrazoles in the solid state and in solution at low temperature

19F,31P,1H NMR and X-ray crystallographic studies of (pentafluorophenyl)3−n (4-pyrazol-1-yl-2,3,5,6-tetrafluorophenyl) n=1,2,3 Phosphines

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.

A solid-state NMR, X-ray diffraction, and ab initio computational study of hydrogen-bond structure and dynamics of pyrazole-4-carboxylic acid chains.

A structural study of pyrazole-1-carboxamides by X-ray crystallography and 13C CPMAS NMR spectroscopy

Advances Towards The Discovery of GPR55 Ligands

Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review.

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

An experimental (NMR) and theoretical (GIAO) study of the tautomerism of benzotriazole in solution

Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally

Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats

Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles.

Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.

Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives

Antitumor Cannabinoid Chemotypes: Structural Insights

Aromatic propellenes. Part 1. NMR spectroscopy, X-ray crystal and molecular structure of hexa(3,5-dimethylpyrazol-1-yl)benzene

Benzyl-1,2,4-triazoles as CB 1 Cannabinoid Receptor Ligands: Preparation and In Vitro Pharmacological Evaluation.

Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.

CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications

Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes

Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update

Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

Chromenopyrazoles: non-psychoactive and selective CB₁ cannabinoid agonists with peripheral antinociceptive properties

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

Description of a bivalent cannabinoid ligand with hypophagic properties

Determination of the absolute configuration of 1,3,5-triphenyl-4,5-dihydropyrazole enantiomers by a combination of VCD, ECD measurements, and theoretical calculations

Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor

Dynamic NMR study of the mechanisms of double, triple, and quadruple proton and deuteron transfer in cyclic hydrogen bonded solids of pyrazole derivatives.

Efficient syntheses of new classes of regiochemically pure benzoporphyrin derivatives

Emerging strategies targeting CB2 cannabinoid receptor: Biased agonism and allosterism

Exploring the Benzimidazole Ring as a Substitution for Indole in Cannabinoid Allosteric Modulators

Fentanyl and its analogue N-(1-phenylpyrazol-3-yl)-N-[1-(2-phenylethyl)-4-piperidyl]propanamide: 1H- and 13C-NMR spectroscopy, X-ray crystallography, and theoretical calculations

Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.

Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism

Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for mu opioid and I2-imidazoline receptors: synthesis and pharmacological screening.

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.

Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage

Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.

Microwave spectra and ab initio calculations of 1-nitropyrazole

Multiple hydrogen bonds and tautomerism in naphthyridine derivatives

New Methods for the Synthesis of Cannabidiol Derivatives

New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking

Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21

Novel approaches and current challenges with targeting the endocannabinoid system

Photosensitization with derivatives of chlorin p6

Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer.

Solid-state structure of NH-pyrazolium hydrochlorides and hydrobromides by X-ray crystallography and CPMAS NMR

Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides

Structure and Dynamics of 3,5-Di-tert-butylpyrazole Probed by Combined X-ray Crystallography and 15N Solid State NMR

Structure of 3-nitropyrazole in solution and in the solid state

Structure of a 4-nitroso-5-aminopyrazole and its salts: tautomerism, protonation, and E/Z isomerism

Syntheses and preliminary in vivo photodynamic efficacy of benzoporphyrin derivatives from phylloerythrin and rhodoporphyrin XV methyl esters and aspartyl amides

Synthesis and molecular structure of 3-(2-benzyloxy-6-hydroxyphenyl)-5-styrylpyrazoles. Reaction of 2-styrylchromones and hydrazine hydrate

Synthesis and molecular structure of new O/N/O ligands: Bis-phenol-pyridine and bis-phenol-pyrazole

Synthesis and opioid activity of new fentanyl analogs.

Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites

Synthesis of a novel CB2 cannabinoid-porphyrin conjugate based on an antitumor chromenopyrazoledione

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.

Synthesis, structure (NMR and mass spectrometry) and conformational analysis of heterocyclic analogues of dibenzo[a,e]cycloocta-1,5-diene: 5,6,12,13-tetrahydrobispyrazolo[1,2-a:1′,2′-e][1,2,5,6]tetraazocinediium dihalides

Synthetic cannabinoid quinones: preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity.

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

Tautomerism of hydroxychromenopyrazoles

The search for proton mobility in solid pyrazoles: molecular and crystal structure of 3(5)-phenyl-4-bromo-5(3)-methylpyrazole

The structure of the agrochemical fungicidal 4-chloro-3-(3,5-dichlorophenyl)-1H-pyrazole (RPA 406194) and related compounds

Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?

Use of the chlorophyll derivative, purpurin-18, for syntheses of sensitizers for use in photodynamic therapy