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List of works by Mark A. Behlke

A direct comparison of anti-microRNA oligonucleotide potency.

scientific article published on 28 April 2010

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

scientific article published on 06 August 2018

A miR-19 regulon that controls NF-κB signaling

scientific article

A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator

scientific article

A modular platform for targeted RNAi therapeutics.

scientific article published on 29 January 2018

A role for human Dicer in pre-RISC loading of siRNAs

scientific article

A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs

scientific article published on 15 October 2008

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

scientific article published on 30 April 2006

Advances in molecular and cellular therapies for hearing loss.

scientific article

Altered Purkinje cell miRNA expression and SCA1 pathogenesis

scientific article published on 30 January 2013

Alternative splicing of murine T-cell receptor β-chain transcripts

scientific article published in Nature

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

scientific article

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.

scientific article published on 11 April 2018

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation.

scientific article

Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish

scientific article published on 5 October 2015

Assessing the sensitivity of commercially available fluorophores to the intracellular environment.

scientific article published on 14 August 2008

Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells

scientific article

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

scientific article published on 18 November 2020

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

scientific article published on 17 November 2015

Central delivery of Dicer-substrate siRNA: a direct application for pain research

scientific article published on 3 June 2008

Characterization of modified antisense oligonucleotides in Xenopus laevis embryos

scientific article published on 01 January 2006

Chemical Modification of CRISPR gRNAs Eliminate type I Interferon Responses in Human Peripheral Blood Mononuclear Cells

scientific article published on 29 January 2018

Chemical modification and design of anti-miRNA oligonucleotides.

scientific article

Chemical modification of siRNAs for in vivo use.

scientific article published on December 2008

Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model

scientific article

Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides.

scientific article published on 25 November 2014

Cre-dependent DNA recombination activates a STING-dependent innate immune response

scientific article published on 10 May 2016

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs

scientific article

Degradation of Nuclease-Stabilized RNA Oligonucleotides in Mycoplasma-Contaminated Cell Culture Media ⬇️

scientific article published on January 9, 2012

Design of LNA probes that improve mismatch discrimination

scientific article

Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells

scientific article

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.

scientific article

Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs

scientific article

Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability

scientific article published in February 2005

Effects of sodium ions on DNA duplex oligomers: improved predictions of melting temperatures.

scientific article published in March 2004

Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro

scientific article published on 26 April 2013

Engineered transfer RNAs for suppression of premature termination codons

scientific article published on 18 February 2019

Evaluation and Reduction of CRISPR Off-Target Cleavage Events

scientific article published on 20 May 2019

Fast, Facile, Hypersensitive Assays for Ribonucleolytic Activity

article

Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.

scientific article

Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development

scientific article published on 15 June 2016

Genetic modulation of TLR8 response following bacterial phagocytosis.

scientific article published on September 2010

Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling.

scientific article

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

scientific article published on 01 December 2019

Identification of preexisting adaptive immunity to Cas9 proteins in humans

scientific article published on 28 January 2019

Imaging the directed transport of single engineered RNA transcripts in real-time using ratiometric bimolecular beacons

scientific article published in 2014

In vivo SELEX for Identification of Brain-penetrating Aptamers.

scientific article

In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours.

scientific article published on 12 November 2013

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8. ⬇️

scientific article

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

scientific article published on 01 October 2010

Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo

scientific article

Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia

scientific article published on 28 August 2012

Modified Polyadenylation-Based RT-qPCR Increases Selectivity of Amplification of 3'-MicroRNA Isoforms.

scientific article published on 24 January 2018

Non-nucleotide Modification of Anti-miRNA Oligonucleotides.

scientific article

Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe

scientific article published on 02 February 2014

Nucleotide bias observed with a short SELEX RNA aptamer library

scientific article

Pancreas-enriched miRNA refines endocrine cell differentiation ⬇️

scientific article published on July 4, 2012

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia

scientific article published on 15 July 2014

Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs

scientific article published on October 2013

Predicting stability of DNA duplexes in solutions containing magnesium and monovalent cations

scientific article published on 19 April 2008

Progress Toward In Vivo Use of siRNAs-II ⬇️

scientific article published on December 20, 2011

Progress towards in vivo use of siRNAs

scientific article

Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo

scientific article published on 7 November 2011

RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB

scientific article

RNA inhibition highlights cyclin D1 as a potential therapeutic target for mantle cell lymphoma

scientific article

RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers

scientific article

Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity

scientific article published on 5 April 2017

Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection

scientific article

Ratiometric bimolecular beacons for the sensitive detection of RNA in single living cells.

scientific article

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.

scientific article published on January 2006

Rational design of immunostimulatory siRNAs.

scientific article

Real-time imaging of single engineered RNA transcripts in living cells using ratiometric bimolecular beacons.

scientific article

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction.

scientific article

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

scientific article

SNP detection in mRNA in living cells using allele specific FRET probes

scientific article (publication date: 2013)

SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation

scientific article published on 18 October 2016

Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.

scientific article published on 15 June 2015

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

scientific article

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

scientific article published on 25 March 2017

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis

scientific article published in Scientific Reports

Single-molecule detection and tracking of RNA transcripts in living cells using phosphorothioate-optimized 2'-O-methyl RNA molecular beacons

scientific article published on 24 May 2016

Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress

scientific article

Spectroscopic features of dual fluorescence/luminescence resonance energy-transfer molecular beacons

scientific article published in August 2003

Spinal NTS2 receptor activation reverses signs of neuropathic pain

scientific article published on 11 June 2013

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

scientific article

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

scientific article published on 30 April 2006

Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA.

scientific article

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

scientific article published on 26 December 2004

T-cell receptor VT beta genes in natural populations of mice

scientific article published on 01 January 1988

Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins

scientific article published on 30 January 2013

The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test

scientific article

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.

scientific article published on February 2011

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo.

scientific article published on 22 March 2011

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