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List of works by Gordon Chan

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

scientific journal article

A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores

scientific article

Antitumor Activity of Lankacidin Group Antibiotics Is Due to Microtubule Stabilization via a Paclitaxel-like Mechanism.

scientific article published on 08 October 2016

Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores

scientific article published on 06 December 2007

CENP-E function at kinetochores is essential for chromosome alignment.

scientific article published in December 1997

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

scientific article

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

scientific article

Dynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acid

scientific article

Epigenetic regulation of centromere formation and kinetochore function.

scientific article published on August 2006

Epigenetics regulate centromere formation and kinetochore function.

scientific article published on August 2008

G2 histone methylation is required for the proper segregation of chromosomes.

scientific article published on 28 July 2009

HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint.

scientific article published on 14 January 2008

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

scientific article

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

scientific article

Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition

scientific article

Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis

scientific article published on 18 February 2019

Kinetochore structure and function

scientific article

Lipids beyond membranes; farnesylation targets Spindly to kinetochores

scientific article published on June 2015

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

scientific article published in December 1998

Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization

scientific article

Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor

scientific article published on 30 March 2022

Ninein is expressed in the cytoplasm of angiogenic tip-cells and regulates tubular morphogenesis of endothelial cells.

scientific article

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis.

scientific article

Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel

scientific article published on 13 May 2017

Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration.

scientific article published on 13 May 2016

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

scientific article

Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention.

scientific article published on 3 September 2004

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint

scientific article

Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein

scientific article

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

scientific article

Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.

scientific article

hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain

scientific article published on 01 May 2011

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