List of works - Giosuè Costa

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

scientific article published on 25 September 2015

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: a new scaffold for the selective inhibition of monoamine oxidase B.

scientific article

A Comparative Docking Strategy to Identify Polyphenolic Derivatives as Promising Antineoplastic Binders of G-quadruplex DNA c-myc and bcl-2 Sequences

scientific article

ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas

scientific article published on 23 September 2019

Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques

scientific article published on 21 June 2016

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures.

scientific article

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

scientific article published on 13 March 2015

C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships

scientific article published on 26 March 2019

Chemoinformatic Database Building and in Silico Hit-Identification of Potential Multi-Targeting Bioactive Compounds Extracted from Mushroom Species.

scientific article

Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops

scientific article

Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders.

scientific article published on 16 June 2011

DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

scientific article published on 26 August 2020

Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach

scientific article published on 07 March 2018

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide,

scientific article published on 4 March 2016

Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage

scientific article published on 6 January 2013

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

scientific article published on November 2010

Docking analysis and resistance evaluation of clinically relevant mutations associated with the HIV-1 non-nucleoside reverse transcriptase inhibitors nevirapine, efavirenz and etravirine

scientific article published on 27 September 2011

Effect of maraviroc on non-R5 tropic HIV-1: refined analysis of subjects from the phase IIb study A4001029.

scientific article

Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products.

scientific article published on 15 January 2015

Erratum for: Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products

scientific article published on 27 January 2015

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

scientific article published in Scientific Reports

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics

scientific article published on 21 February 2020

GRID-based three-dimensional pharmacophores II: PharmBench, a benchmark data set for evaluating pharmacophore elucidation methods

scientific article

HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors

scientific article

Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitors

scientific article published on 3 March 2014

Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.

scientific article

Identification and structural characterization of novel genetic elements in the HIV-1 V3 loop regulating coreceptor usage

scientific article published in January 2011

Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization.

scientific article

Identification of a rare mutation at reverse transcriptase Lys65 (K65E) in HIV-1-infected patients failing on nucleos(t)ide reverse transcriptase inhibitors

scientific article published on 7 June 2013

Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.

scientific article

In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with IX and XII hCA Inhibition

scientific article published on 21 August 2020

In Silico Identification of Piperidinyl-amine Derivatives as Novel Dual Binders of Oncogene c-myc/c-Kit G-quadruplexes

scientific article published on 10 July 2018

In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold

scientific article

Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage

scientific article published on 8 June 2015

Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids.

scientific article

Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies

scientific article published on 28 January 2016

Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase

scientific article published on 03 February 2011

Molecular interaction fields in drug discovery: recent advances and future perspectives

Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA?

scientific article

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

scientific article published on 06 May 2020

Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains

scientific article published on 22 January 2017

Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7

scientific article published on 25 November 2020

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

scientific article published on 18 April 2012

New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies

scientific article published on 22 May 2014

New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors

scientific article published on 7 April 2014

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

scientific article published on 21 January 2019

Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance

scientific article published on 24 January 2018

SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.

scientific article

Simple choline esters as potential anti-Alzheimer agents.

scientific article published in January 2010

Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors

scientific article published on 3 September 2010

Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen

scientific article published on 17 May 2013

Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations.

scientific article published on 24 December 2014

Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.

scientific article published on 17 July 2010

TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line

scientific article

Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach

scientific article published on 3 November 2022

Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?

scientific article

The HIV-1 reverse transcriptase polymorphism A98S improves the response to tenofovir disoproxil fumarate+emtricitabine-containing HAART both in vivo and in vitro

scientific article published on 25 July 2016

The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

scientific article published on 30 January 2020

The polymorphisms of DNA G-quadruplex investigated by docking experiments with telomestatin enantiomers.

scientific article published in January 2012

List of works by Giosuè Costa

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: a new scaffold for the selective inhibition of monoamine oxidase B.

A Comparative Docking Strategy to Identify Polyphenolic Derivatives as Promising Antineoplastic Binders of G-quadruplex DNA c-myc and bcl-2 Sequences

ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas

Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures.

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships

Chemoinformatic Database Building and in Silico Hit-Identification of Potential Multi-Targeting Bioactive Compounds Extracted from Mushroom Species.

Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops

Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders.

DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

Design and Development of Biomimetic Nanovesicles Using a Microfluidic Approach

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide,

Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

Docking analysis and resistance evaluation of clinically relevant mutations associated with the HIV-1 non-nucleoside reverse transcriptase inhibitors nevirapine, efavirenz and etravirine

Effect of maraviroc on non-R5 tropic HIV-1: refined analysis of subjects from the phase IIb study A4001029.

Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products.

Erratum for: Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products

Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics

GRID-based three-dimensional pharmacophores II: PharmBench, a benchmark data set for evaluating pharmacophore elucidation methods

HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors

Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitors

Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.

Identification and structural characterization of novel genetic elements in the HIV-1 V3 loop regulating coreceptor usage

Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization.

Identification of a rare mutation at reverse transcriptase Lys65 (K65E) in HIV-1-infected patients failing on nucleos(t)ide reverse transcriptase inhibitors

Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.

In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with IX and XII hCA Inhibition

In Silico Identification of Piperidinyl-amine Derivatives as Novel Dual Binders of Oncogene c-myc/c-Kit G-quadruplexes

In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold

Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage

Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids.

Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies

Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase

Molecular interaction fields in drug discovery: recent advances and future perspectives

Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA?

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains

Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies

New raltegravir resistance pathways induce broad cross-resistance to all currently used integrase inhibitors

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance

SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.

Simple choline esters as potential anti-Alzheimer agents.

Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors

Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen

Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations.

Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.

TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line

Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach

Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?

The HIV-1 reverse transcriptase polymorphism A98S improves the response to tenofovir disoproxil fumarate+emtricitabine-containing HAART both in vivo and in vitro

The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

The polymorphisms of DNA G-quadruplex investigated by docking experiments with telomestatin enantiomers.