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List of works by Paul A Overbeek

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

scientific journal article

5′‐flanking sequences of the human HPRT gene direct neuronal expression in the brain of transgenic mice ⬇️

scientific article published on June 15, 1994

A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice

scientific article

A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice

scientific journal article

A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis

scientific article

A transgenic insertion causing cryptorchidism in mice

scientific article published on 01 May 2001

A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse

scientific article published in December 2000

Activated Ras alters lens and corneal development through induction of distinct downstream targets

scientific article

Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.

scientific article published in January 2004

Activation of unfolded protein response in transgenic mouse lenses.

scientific article

Anomalous development of the hepatobiliary system in the Inv mouse

scientific article published in August 1999

BMP signaling is required for development of the ciliary body.

scientific article published in October 2002

Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter ⬇️

scientific article published on December 1, 1992

Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways

scientific article published on 21 August 2009

CREB-binding protein/p300 co-activation of crystallin gene expression

scientific article (publication date: 5 July 2002)

Characterization of five members of the actin gene family in the sea urchin.

scientific article published on December 1981

Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice.

scientific article

Cloning of inv, a gene that controls left/right asymmetry and kidney development.

scientific article published in September 1998

Coinjection strategy for visual identification of transgenic mice

scientific article published on 01 December 1991

Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.

scientific article

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

scientific article published on February 1995

Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice

scientific article

Differential expression of alpha A- and alpha B-crystallin during murine ocular development

scientific article published in October 1996

Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling.

scientific article published on 09 June 2013

Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice

scientific article published in June 1998

Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice

scientific article published on 01 September 2004

Diverse Genetic Regulatory Elements are Required to Direct the Proper Tissue-Specific and Developmental Expression of the Murine Adenosine Deaminase Gene ⬇️

scientific article published on January 1, 1994

Dominant inhibition of lens placode formation in mice

scientific article published on 26 August 2008

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

scientific article published on 07 May 2019

Ectopic gland induction by lens-specific expression of keratinocyte growth factor (FGF-7) in transgenic mice

scientific article published in October 1999

Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells

scientific article

Endogenous and ectopic gland induction by FGF-10

scientific journal article

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

scientific article

Epidermal surface antigen (MS17S1) is highly conserved between mouse and human

scientific article

Essential role of BMPs in FGF-induced secondary lens fiber differentiation.

scientific article

Evidence for Serum Response Factor-Mediated Regulatory Networks GoverningSM22αTranscription in Smooth, Skeletal, and Cardiac Muscle Cells ⬇️

scientific article (publication date: 15 July 1997)

Expression of a truncated FGF receptor results in defective lens development in transgenic mice

scientific article published on 01 December 1995

Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP responsive element

scientific article published in November 1997

Expression of the rasT24 oncogene in the ciliary body pigment epithelium and retinal pigment epithelium results in hyperplasia, adenoma, and adenocarcinoma.

scientific article published in July 1993

Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes ⬇️

scientific article published on December 15, 1992

Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice

scientific article published on 01 February 1995

FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development

scientific journal article

Formation of corneal endothelium is essential for anterior segment development - a transgenic mouse model of anterior segment dysgenesis

scientific article published in February 2000

Gene expression profiling in embryonic mouse lenses.

scientific article published on 26 December 2006

Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

scientific article published on July 1997

Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system

scientific article published on 01 May 2007

Hair follicles are required for optimal growth during lateral skin expansion

scientific article published on 23 April 2009

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness

scientific article published on 2 March 2012

Human adipose tissue as a reservoir for memory CD4+ T cells and HIV.

scientific article

Identification of a retina-specific footprint within the retina-specific regulatory region of the human interphotoreceptor retinoid-binding protein gene.

scientific article published on September 1994

Induction of corneal myofibroblasts by lens-derived transforming growth factor beta1 (TGFbeta1): a transgenic mouse model.

scientific article published on 6 November 2009

Inhibition of cell death by lens-specific overexpression of bcl-2 in transgenic mice

scientific article published on 01 January 1997

Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice

scientific article published on 01 February 2002

Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb.

scientific article published on 23 January 2004

Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice

scientific article published in June 2004

Insertional inactivation of the downless gene in a family of transgenic mice.

scientific article published in August 1989

Insertional mutagenesis by a hybrid piggyBac and sleeping beauty transposon in the rat.

scientific article

Insertional mutation that causes acrosomal hypo-development: its relationship to sperm head shaping

scientific article published in April 1994

Intracorneal positioning of the lens in Pax6-GAL4/VP16 transgenic mice

scientific article published on 26 October 2005

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse ⬇️

scientific article published on October 1, 1998

Involvement of a novel Tnf receptor homologue in hair follicle induction

scientific article published in August 1999

Lens-specific VEGF-A expression induces angioblast migration and proliferation and stimulates angiogenic remodeling

scientific article published in July 2000

Lens-specific expression of PDGF-A alters lens growth and development

scientific article published in December 1996

Lens-specific expression of PDGF-A in transgenic mice results in retinal astrocytic hamartomas

scientific article published on 01 November 1996

Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3

scientific article

Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts

scientific article

Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiation

scientific article published in July 2005

Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant.

scientific article

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

scientific article published on 17 October 2016

Long-range activation of Sox9 in Odd Sex (Ods) mice.

scientific article published on 28 April 2004

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

scientific article

Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes

scientific article (publication date: July 2014)

Misexpression of IGF-I in the mouse lens expands the transitional zone and perturbs lens polarization

scientific article published on 01 March 2001

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells ⬇️

scientific article published on February 8, 2012

Multiple autism-like behaviors in a novel transgenic mouse model ⬇️

scientific article published on November 17, 2010

Mutant Cohesin in Premature Ovarian Failure

scientific article (publication date: 6 March 2014)

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

scientific article

Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo

scientific article

Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

scientific article

Oncogenesis of the lens in transgenic mice

scientific article published in March 1987

Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models

scientific article

Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression.

scientific article published on March 1999

Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice

scientific article published in September 1998

Patterning the optic neuroepithelium by FGF signaling and Ras activation ⬇️

scientific article published on December 1, 2001

Pax6 dosage requirements in iris and ciliary body differentiation

scientific article published on 27 June 2009

Perinatal ablation of the mouse lens causes multiple anterior chamber defects

scientific article published on 18 December 2007

Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice ⬇️

scientific article published on February 15, 1992

Photoreceptor-specific activity of the human interphotoreceptor retinoid-binding protein (IRBP) promoter in transgenic mice

scientific article published on 01 August 1992

Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model

scientific article

Promoter sequences of murine alpha A crystallin, murine alpha 2(I) collagen or of avian sarcoma virus genes linked to the bacterial chloramphenicol acetyl transferase gene direct tissue-specific patterns of chloramphenicol acetyl transferase express

scientific article

Ras signaling is essential for lens cell proliferation and lens growth during development

scientific article published on 4 July 2006

Regulation of choroid development by the retinal pigment epithelium.

scientific article published on 2 December 2001

Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein

scientific article published on 01 January 1996

Regulation of mouse lens fiber cell development and differentiation by the Maf gene

scientific journal article

Renal cysts of inv/inv mice resemble early infantile nephronophthisis

scientific article published in July 2004

Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation

scientific journal article

Retina-specific expression from the IRBP promoter in transgenic mice is conferred by 212 bp of the 5'-flanking region

scientific article published in November 1991

Retinal ablation and altered lens differentiation induced by ocular overexpression of BMP7.

scientific article published in February 2002

Reversal of left-right asymmetry: a situs inversus mutation.

scientific article

Right and left go dHAND and eHAND

scientific article published on 01 June 1997

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.

scientific article published on 13 June 2018

Systematic analysis of E-, N- and P-cadherin expression in mouse eye development.

scientific article

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

scientific article published in May 2000

TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes.

scientific article published on June 1995

TGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract

scientific article published on February 2002

Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo.

scientific article published on July 2010

Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia

scientific article published in January 1995

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys

scientific article published in April 1993

Testis structure in thesys (symplastic spermatids) mouse ⬇️

scientific article published on October 1, 1991

The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development.

scientific article published in April 2004

The bHLH Factors, dHAND and eHAND, Specify Pulmonary and Systemic Cardiac Ventricles Independent of Left–Right Sidedness ⬇️

scientific article published on April 15, 1998

The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs

scientific article (publication date: 2014)

The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos

scientific article published in August 1999

The porcine SRY promoter is transactivated within a male genital ridge environment

scientific article published on 01 August 2002

Tissue Specific Expression of Testis Angiotensin Converting Enzyme is Not Determined by the −32 Nonconsensus TATA Motif

scientific article published on 01 June 1996

Tissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding protein.

scientific article published in May 1990

Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences

scientific article

Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.

scientific article

Transgenic mice carrying a PSArasT24 hybrid gene develop salivary gland and gastrointestinal tract neoplasms.

scientific article published in March 1995

Transgenic mice demonstrate a testis-specific promoter for angiotensin-converting enzyme

scientific article

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development ⬇️

scientific article published on October 1, 2011

Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen.

scientific article published in February 1996

Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues

scientific article published in December 1999

Use of a simplified single-site PCR to facilitate cloning of genomic DNA sequences flanking a transgene integration site

scientific article published on 01 November 1991

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

scientific article (publication date: March 2001)

YAC rescue of downless locus mutations in mice

scientific article published on 01 November 1998

exma: an X-linked insertional mutation that disrupts forebrain and eye development.

scientific article published on April 2002

miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy

scientific article published on 28 June 2016

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