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List of works by Alison Goate

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

scientific article

A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains

scientific article published on 18 January 2017

A Family-Based Analysis of the Association of the Dopamine D2 Receptor (DRD2) with Alcoholism

scholarly article by Howard J. Edenberg et al published April 1998 in Alcoholism: Clinical and Experimental Research

A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly

scientific article published on August 2015

A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9

scientific article published on 27 December 2007

A Tale of Two Genes: Microglial Apoe and Trem2.

scientific article

A cholinergic receptor gene (CHRM2) affects event-related oscillations

scientific article published in September 2006

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.

scientific article published on 19 June 2017

A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele

scientific article published on March 2013

A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities.

scientific article published on March 2005

A full genome scan for late onset Alzheimer's disease

scientific article published in February 1999

A genome wide association study of fast beta EEG in families of European ancestry

scientific article published on 28 December 2016

A genome-wide association study of DSM-IV cannabis dependence

scientific article

A genome-wide association study of alcohol dependence

scientific article

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53

scientific article published on 23 October 2012

A genome-wide screen for genes influencing conduct disorder

scientific article published on January 2004

A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence

scientific article published in January 2004

A large-scale genome-wide association study meta-analysis of cannabis use disorder

scientific article published on 20 October 2020

A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks

scientific journal article

A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence

scientific article

A new statistic to evaluate imputation reliability

scientific article

A novel Alzheimer disease locus located near the gene encoding tau protein.

scientific article

A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman

scientific article published on January 2014

A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs

scientific article

A physical map of the human APP gene in YACs

article

A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis

scientific article

A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset

scientific article published in June 1997

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

scientific article published in January 1998

A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

scientific article published on 25 September 2015

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

scientific article published on 17 October 2003

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

scientific article (publication date: 8 April 1999)

A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease

scientific article published on 01 August 2020

A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications

scientific journal article

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

scientific article

A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence

scientific article published on 4 March 2008

A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence

scientific article published on 02 June 2008

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease

scientific article

A sex-adjusted and age-adjusted genome screen for nested alcohol dependence diagnoses

scientific article

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

scientific article published on 11 March 2020

A voxel-based morphometry study of volumetric MRI in familial Alzheimer's disease

A yeast artificial chromosome contig from human chromosome 14q24 spanning the Alzheimer's disease locus AD3.

scientific article published on August 1995

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

scientific article published on 20 April 2016

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

scientific article

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

scientific article

APOE ε4 genotype predicts memory for everyday activities

scientific article

APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42

scientific article

Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17.

scientific article published in July 2000

Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17.

scientific article

Age and amyloid effects on human central nervous system amyloid-beta kinetics

scientific article

Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) an

scientific article published on March 2014

Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk

scientific article published in July 2007

Allele-Specific Expression and High-Throughput Reporter Assay Reveal Functional Variants in Human Brains with Alcohol Use Disorders

Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

scientific article published on 02 September 2019

Alpha-2 macroglobulin gene and Alzheimer disease

scientific article published in May 1999

Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

scientific article published on January 2004

Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease

scientific article published in September 1996

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction

scientific article

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.

scientific article

Alzheimer's disease genetics: from the bench to the clinic

scientific article published on July 2014

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

scientific article

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta

scientific article published on 24 September 2008

Alzheimer's disease untangled

scientific article

Alzheimer's disease: the challenge of the second century

scientific article published on April 2011

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

scientific article

Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data

scientific article

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.

scientific article

An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction

scientific article

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

scientific article

An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project

scientific article published on June 2008

An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.

scientific article published on 10 January 2017

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

scientific article published in November 2017

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

article

Anxiety proneness linked to epistatic loci in genome scan of human personality traits

scientific article published in July 1998

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

scientific article

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

article

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms

scientific article published on 12 April 2007

Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders

scientific article published on 14 February 2013

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred

scientific article published in August 2003

Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent?

article

Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.

scientific article published in January 2018

Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease

scientific article

Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample

scientific article published in July 2006

Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study

scientific article

Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence

scientific article

Association of GABRG3 with alcohol dependence

scientific article (publication date: 2004)

Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals

scientific article

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels

scientific article

Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis

article

Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults.

scientific article published on March 2009

Association of genes involved in calcium and potassium pathways with opioid dependence

scientific article

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family

scientific article

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

scientific article

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence

scientific article

Association of substance dependence phenotypes in the COGA sample

scientific article

Association of the kappa-opioid system with alcohol dependence

scientific article

Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease

scientific article

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme

scientific article

Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP).

scientific article published in June 2007

Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

scientific article published in 2022

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Autosomal dominant dementia with widespread neurofibrillary tangles.

scientific article published in October 1997

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

scientific article published on 01 January 2020

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease

scientific article

Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide

scientific article

Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation

scientific article

Biomarkers will revolutionize the way we diagnose and treat Alzheimer's disease

scientific article published in February 2010

Blood pressure and coronary heart disease

scientific article published in The Lancet

Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

scientific article published on 23 November 2005

C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease

scientific article published on June 2013

CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction

scientific article

CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results

scientific article

CYP2A6 metabolism in the development of smoking behaviors in young adults

scientific article published on 29 December 2016

CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes

scientific article (publication date: 2013)

Calcium phosphatase calcineurin influences tau metabolism

scientific article published on 06 June 2012

Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease

scientific article

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

scientific article

Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests

scientific article

Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration

scientific article

Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40.

scientific article

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

scientific article

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

scientific article published on 29 November 2006

Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry

scientific article

Clearance of amyloid-beta by circulating lipoprotein receptors

scientific article

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

scientific article

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

article

Clinical features of early onset, familial Alzheimer's disease linked to chromosome 14

scholarly article by Michael Mullan et al published 27 February 1995 in American Journal of Medical Genetics Part A

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease

scientific article published on 01 May 2019

Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype

scientific article published in March 1998

Coding variants in TREM2 increase risk for Alzheimer's disease

scientific article

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.

scientific article

Common biological networks underlie genetic risk for alcoholism in African- and European-American populations.

scientific article published on 10 May 2013

Common polygenic variation enhances risk prediction for Alzheimer's disease

scientific article published on 21 October 2015

Common polymorphisms in FMO1 are associated with nicotine dependence

scientific article published on July 2011

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

scientific article published on April 2004

Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation

Construction of a Detailed Physical and Transcript Map of the FTDP-17 Candidate Region on Chromosome 17q21

Copy number variation accuracy in genome-wide association studies

scientific article

Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence

scientific article

Correction: GWAS on family history of Alzheimer's disease.

scientific article

Correction: In Vivo Human Apolipoprotein E Isoform Fractional Turnover Ratesin the CNS.

scientific article published on 3 July 2012

Correction: Pathway Analysis of Smoking Quantity in Multiple GWAS Identifies Cholinergic and Sensory Pathways.

scientific article published on 5 August 2013

Correction: Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

scientific article published on 10 May 2012

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

scientific article published on 21 October 2019

Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease

scientific article

Cross-sectional cerebral volumetric differences and associations with estimated time to age-at-onset in familial Alzheimer's disease: Findings from the DIAN study

article

Cruchaga & Goate reply

scientific article

Cruchaga & Goate reply

scientific article published in Nature

Current concepts in the pathogenesis of Alzheimer's disease

scientific article

DAPK1 variants are associated with Alzheimer's disease and allele-specific expression

scientific article published on 17 July 2006

DSM-5 cannabis use disorder: a phenotypic and genomic perspective

scientific article

Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function

scientific article

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network

scientific article (publication date: October 2012)

Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior

scientific article published on 29 August 2011

Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease

scientific article

Discovery and validation of autosomal dominant Alzheimer's disease mutations

scientific article published on 18 July 2018

Dissection of the phenotypic and genotypic associations with nicotinic dependence

scientific article published on 18 November 2011

Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?

scientific article published on September 2008

Dosage transmission disequilibrium test (dTDT) for linkage and association detection

scientific article

E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles

scientific article published on 01 January 1997

Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network

scientific article published on 15 February 2015

Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease

scientific article published on 25 August 2018

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

scientific article

Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram

scientific article

Empirical design of a variant quality control pipeline for whole genome sequencing data using replicate discordance

scientific article published on 06 November 2019

Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism

scientific article

Epigenetic regulation of brain region-specific microglia clearance activity.

scientific article published on 23 July 2018

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scholarly article published in Nature Genetics

Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

article

Erratum: The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data

scientific article

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease.

scientific article published on 4 April 2018

Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder

scientific article published in May 2001

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts

scientific article published on September 2010

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

article

Evidence of CNIH3 involvement in opioid dependence.

scientific article published on 4 August 2015

Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome

scientific article

Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease

scientific article

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

scientific article published on May 2012

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

scientific article

Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use

scientific article published on 06 December 2018

Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis

scientific article published in 2011

Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains

scientific article

Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies

scientific article

Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation

scientific article published in May 2007

FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy

scientific article

Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study

scientific article

Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.

scientific article published in October 2007

Family-based association analysis of alcohol dependence criteria and severity

scientific article published on 09 September 2013

Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.

scientific article

Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease

scientific article

Full genome screen for Alzheimer disease: Stage II analysis

article

Functional Variants in TAS2R38 and TAS2R16 Influence Alcohol Consumption in High-Risk Families of African-American Origin

article

Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior

scientific article

Functional connectivity in autosomal dominant and late-onset Alzheimer disease

scientific article

Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence

scientific article

Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs

scientific article

Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence

scientific article published on March 2009

GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence

scientific article

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

scientific article

GWAS on family history of Alzheimer's disease.

scientific article

Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study

scientific article published in June 2008

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genes for a 'Wellderly' Life

scientific article published on 13 June 2016

Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology

scientific article published on 15 November 2016

Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project

scientific article published on 27 February 2018

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

scientific article

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

scientific article

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

scientific article

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease

scientific article (publication date: March 2005)

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

article

Genetic characterization of a familial non-specific dementia originating in Jutland, Denmark

scientific article published in February 1993

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

scientific article (publication date: 15 November 2010)

Genetic heterogeneity in Alzheimer disease and implications for treatment strategies

scientific article

Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood

scientific article published on 20 May 2013

Genetic linkage findings for DSM-IV nicotine withdrawal in two populations

scientific article

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

scientific article published in September 1990

Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples

scientific article published on 26 March 2007

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic screening in two Iranian families with early-onset Alzheimer's disease identified a novel PSEN1 mutation

scientific article published on 23 October 2017

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits.

scientific article

Genetic studies on chromosome 12 in late-onset Alzheimer disease

scientific article published in August 1998

Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease

scientific article published in July 1999

Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families

scientific article

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).

scientific article

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

scientific article

Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism

scientific article

Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease

scientific article published on 21 December 2016

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder

scientific article

Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease

scientific article

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

scientific article published on 15 February 2021

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE

scientific article

Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels

scientific article published on 28 August 2018

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

scientific article published on 28 February 2017

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation

scientific article

Genome-wide association study of alcohol dependence implicates a region on chromosome 11.

scientific article

Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

scientific article

Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence

scientific article

Genome-wide association study reveals genetic risk underlying Parkinson's disease

scientific article

Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease

scientific article

Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease

article

Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures

scientific article published on 22 March 2016

Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees

scientific article published in December 2003

Genome-wide search for genes affecting the risk for alcohol dependence

scientific article published on 01 May 1998

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families

scientific journal article

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism

scientific article

Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: A preliminary report

article

Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory

scientific article

Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk

scientific article

H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence

scientific article

HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin

scientific article

Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease

scientific article published on 31 January 2007

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

scientific article

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

scientific article published on 25 July 2018

Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease

article

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

scientific article

In search of causal variants: refining disease association signals using cross-population contrasts

scientific article

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS

scientific article (publication date: 2012)

Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis

scientific article published in October 2007

Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers

scientific article

Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease

scientific article

Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12.

scientific article published in May 1997

Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q.

scientific article published on May 1997

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14, and X.

scientific article published in May 1997

Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 3, 5, 15, 16, 17, and 22

article

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

scientific article published on 12 March 2021

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

scientific article

Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence

scientific article

Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success

scientific article

Interview with Alison Goate

scientific article published in December 2008

Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials

scientific article

Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis

scientific article

Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory

scientific article published in September 2015

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

scientific article (publication date: September 2014)

Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

scientific article

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

scientific article published on 15 February 2018

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

scientific article published on 26 February 2020

Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease

scientific article

Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample

scientific article published on 10 December 2005

Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes

scientific article published in October 2002

Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition

scientific article

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

scientific article

Linkage of an Alcoholism-Related Severity Phenotype to Chromosome 16

scholarly article by Tatiana Foroud et al published December 1998 in Alcoholism: Clinical and Experimental Research

Linkage of an alcoholism-related severity phenotype to chromosome 16

scientific article published on 01 December 1998

Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

scientific article

Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis

scientific article

Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease

scientific article

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

scientific article published on 14 September 2018

MAOA-uVNTR and early physical discipline interact to influence delinquent behavior

scientific article

Mapping the road forward in Alzheimer's disease

scientific article published in December 2011

Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges

scientific article published on February 2012

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

scientific article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

scientific article

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

scientific article published on 07 January 2019

MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis

scientific article published on 06 July 2020

Missense variant in TREML2 protects against Alzheimer's disease

scientific article published on 21 December 2013

Modelling the occurrence and pathology of Alzheimer's disease.

scientific article published on September 1989

Molecular Genetics of Alzheimer's Disease

article

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

scientific article published on April 2008

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

scientific article published on April 1998

Monogenetic determinants of Alzheimer's disease: APP mutations ⬇️

scientific article published on September 1, 1998

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

scientific article published on 20 August 2021

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.

scientific article

Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans

scientific article published on 18 February 2014

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

scientific article published on June 2009

Mutations in APP have independent effects on Abeta and CTFgamma generation

scientific article

Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).

scientific article

Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation

scientific article published in January 2007

Neuropsychological Profile of a Large Kindred with Familial Alzheimer's Disease Caused by the E280A Single Presenilin-1 Mutation

scholarly article by A Ardila published August 2000 in Archives of Clinical Neuropsychology

Neuropsychological profile of a large kindred with familial Alzheimer's disease caused by the E280A single presenilin-1 mutation

scientific article published in August 2000

Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain

scientific article

Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.

scientific article published on 12 March 2009

Nicotinic receptor gene variants influence susceptibility to heavy smoking

scientific article

Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway

scientific article published on 20 May 2010

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

scientific article published in March 1999

No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant.

scientific article published in December 1995

No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample.

scientific article

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

scientific article published in June 2004

Notch3 mutations and the potential for diagnostic testing for CADASIL

scientific article published in The Lancet

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis ⬇️

scientific article published on 19 October 2020

Novel genes identified in a high-density genome wide association study for nicotine dependence

scientific journal article

Novel haplotypes in 17q21 are associated with progressive supranuclear palsy

scientific article

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

scientific article

Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life

scientific article

Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life.

scientific article

Novel progranulin variants do not disrupt progranulin secretion and cleavage

scientific article published on 4 June 2013

PRESENILE DEMENTIA ASSOCIATED WITH MOSAIC TRISOMY 21 IN A PATIENT WITH A DOWN SYNDROME CHILD

scientific article published in The Lancet

Parkinson disease is not associated with C9ORF72 repeat expansions

scientific article published on 30 October 2012

Pathogenic cysteine mutations affect progranulin function and production of mature granulins

scientific article

Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways

scientific article

Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans

scientific article

Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6).

scientific article

Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study

scientific article published on 25 July 2016

Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid

scientific article

Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease

scientific article

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence

scientific article

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.

scientific article

Polygenic risk scores in familial Alzheimer disease

scientific article published on 17 February 2017

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

scientific article

Positive Selection on Loci Associated with Drug and Alcohol Dependence

scientific article

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

scientific article published in January 2000

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

scientific article

Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning

scientific article published on 11 February 2020

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

scientific article published on January 2005

Presenilin endoproteolysis is an intramolecular cleavage

scientific article

Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG

scientific journal article

Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques

scientific article published on August 2009

Presenilins upregulate functional K+ channel currents in mammalian cells

scientific article published in April 1998

Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study.

scientific article published on 21 July 2017

Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases

scientific article published on 03 July 2013

Prion disease

scientific article published in The Lancet

Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes

scientific article

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.

scientific article published on June 2010

Protection against Alzheimer's disease with apoE epsilon 2.

scientific article published in June 1994

Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers

scientific article published on October 2013

Quantitative trait loci analysis of human event-related brain potentials: P3 voltage

scientific article published in April 1998

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

scientific article

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence

scientific article published on 20 September 2013

Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.

scientific article published on 31 October 2011

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

scientific article (publication date: 2012)

Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans

scientific article

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

scientific article

Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting

article

Regional localization and characterization of a DNA segment on the long arm of chromosome 21

scientific article published on 01 February 1987

Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease

scientific article

Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults

scientific article

Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease

scientific article published on 23 June 2020

Reply to Bertram et al.

scientific article published in July 2006

Risk factors for neurocognitive dysfunction after cardiac surgery in postmenopausal women

scientific article published on August 2008

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene

scientific article published in November 1998

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

scientific article published on 14 May 2009

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

scientific article published on 23 September 2020

Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring

scientific article published on June 2009

Role of the beta-amyloid precursor protein in Alzheimer's disease.

scientific article

Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease

scientific article

SNP analysis to dissect human traits.

scientific article

SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease

scientific article

SORL1 variants across Alzheimer's disease European American cohorts

scientific article published on 21 September 2016

SORL1 variants and risk of late-onset Alzheimer's disease

scientific article

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease

scientific article

Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile

scientific article published on June 1, 1992

Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease

scientific article published in August 1991

Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease

scientific article (publication date: August 2003)

Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence

scientific article published in November 1991

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

scientific article published on 21 January 2019

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

scientific article published on 06 June 2020

Sex differences in the genetic predictors of Alzheimer's pathology

scientific article published on 01 September 2019

Sex-specific genetic predictors of Alzheimer's disease biomarkers

scientific article published on 02 July 2018

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

scientific article published on 16 February 2020

Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence

scientific article

Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

scientific article

Stress-response pathways are altered in the hippocampus of chronic alcoholics

scientific article published on 24 August 2013

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

scientific article published in November 2001

Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees

article

Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype

scientific article published in October 2002

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease

scientific article

Susceptibility locus for Alzheimer's disease on chromosome 10.

scientific article

Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis

scientific article

Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

scientific article published on 19 June 2008

TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

scientific article (publication date: November 2009)

TDP-43 A315T mutation in familial motor neuron disease

scientific article published on April 2008

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

scientific article published in July 2007

TREM2 Variants in Alzheimer's Disease ⬇️

scientific article published on November 14, 2012

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

scientific article published on 10 April 2015

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

scientific article

Tau polymorphisms are not associated with Alzheimer's disease

scientific article published on 01 April 2000

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs

scientific article published on 03 February 2020

The Alzheimer's Disease Sequencing Project: Study design and sample selection

scientific article published on 13 October 2017

The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples

scientific article published in September 2005

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

scientific article published on 21 March 2019

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

scientific article

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

scientific article published in October 1996

The Genetic Aetiology of Alzheimer's Disease

scholarly article by Alison M. Goate et al published January 1989 in International Review of Psychiatry

The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample

scientific article published on 21 May 2019

The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17

scientific article

The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers

scientific article

The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data

scientific article

The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease

scientific article published on 15 August 2016

The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach

scientific article

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans

scientific article

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans

scientific article published on December 2013

The future of Alzheimer's disease research: a molecular genetic perspective.

scientific article

The genetics of alcoholism

article

The genetics of late-onset Alzheimer's disease.

scientific article

The genetics of substance dependence

scientific article

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

scientific article published on 02 September 2020

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

scientific article

The search for genetic risk factors associated with suicidal behavior

scientific article

The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease

scientific article

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

scholarly article published 10 March 2018

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

scientific article published on 26 November 2018

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

scientific article published on 6 February 2017

Twenty years of Alzheimer’s disease‐causing mutations ⬇️

scientific article published on November 28, 2011

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity

scientific article published on 7 July 2005

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans

scientific article published on 19 October 2016

Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans

scientific article

Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

scientific article

Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence

scientific article

Untangling Genetic Risk for Alzheimer's Disease

scientific article published on 22 May 2017

Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.

scientific article

Using dimensional models of externalizing psychopathology to aid in gene identification

scientific article published in March 2008

Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence

scientific article published on 30 January 2013

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

scientific article published on 27 September 2018

VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death

scientific article

Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels

scientific article

Variants Weakly Correlated with CHRNA5 D398N Polymorphism Should be Considered in Transcriptional Deregulation at the 15q25 Locus Associated with Lung Cancer Risk

scientific article published on 25 August 2009

Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

scientific article

Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

scientific article

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study

scientific article published on 30 May 2013

Variants in nicotinic receptors and risk for nicotine dependence

scientific article published on 02 June 2008

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans

scientific article

Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms

scientific article published on 17 September 2013

Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking

scientific article (publication date: 2012)

Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy

scientific article published on 28 March 2014

Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition

scholarly article

Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations

scientific article

Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.

scientific article published on 25 April 2017

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

article by Miguel Ángel Araque Caballero et al published 1 October 2018 in Brain

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

scientific article

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

article

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