List of works - Thorkil Ploug

An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers

scientific article

Anatomy of glucose transporters in skeletal muscle. Effects of insulin and contractions

scientific article published on 01 January 1998

Appetite regulation in overweight, sedentary men after different amounts of endurance exercise: a randomized controlled trial

scientific article

Blood vessels and desmin control the positioning of nuclei in skeletal muscle fibers

scientific article published in 2006

Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise—a randomized controlled trial in overweight sedentary males

scientific article published on 01 August 2012

Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET.

scientific article published on April 2014

Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation

scientific article

Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation

scientific article

Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers

scientific journal article

Changes in peak fat oxidation in response to different doses of endurance training.

scientific article published on 18 December 2013

Compliance with physical exercise: using a multidisciplinary approach within a dose-dependent exercise study of moderately overweight men.

scientific article published on 16 September 2013

Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle

scientific article published on 15 October 2013

Contractions activate hormone-sensitive lipase in rat muscle by protein kinase C and mitogen-activated protein kinase

scientific article published on 6 June 2003

Contractions induce phosphorylation of the AMPK site Ser565 in hormone-sensitive lipase in muscle

scientific article published in April 2004

Counterpoint: Glucose phosphorylation is not a significant barrier to glucose uptake by the working muscle

scientific article published on 01 December 2006

Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine

scientific article published on 12 August 2006

Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin.

scientific article published on 8 December 2009

Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men.

scientific article published on 10 July 2013

Disruption of microtubules in rat skeletal muscle does not inhibit insulin- or contraction-stimulated glucose transport

scientific article published on 13 May 2003

Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins

scientific article published on 29 October 2009

Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization.

scientific article published on April 2009

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

scientific article published in June 2006

Ectopic Lipid Deposition Is Associated With Insulin Resistance in Postmenopausal Women

scientific article published on 01 September 2018

Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle

scientific article published in December 1990

Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle

scientific article

Effect of in vivo injection of cholera and pertussis toxin on glucose transport in rat skeletal muscle

scientific article published on 01 January 1997

Effect of intermittent fasting and refeeding on insulin action in healthy men.

scientific article published on 28 July 2005

Effect of prior immobilization on muscular glucose clearance in resting and running rats

scientific article published on 01 October 1988

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

scientific article

Endurance TrainingPer SeIncreases Metabolic Health in Young, Moderately Overweight Men

article

Endurance training augments the stimulatory effect of epinephrine on oxygen consumption in perfused skeletal muscle

scientific article published on 01 April 1984

Excitatory amino acid transporters EAAT-1 and EAAT-2 in temporal lobe and hippocampus in intractable temporal lobe epilepsy

scientific article

Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: a randomized study using FDG PET imaging.

scientific article published on 25 June 2013

Exploring the whereabouts of GLUT4 in skeletal muscle (review).

scientific article

Expression of the synaptic vesicle proteins VAMPs/synaptobrevins 1 and 2 in non-neural tissues

scientific article

Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy

scientific article published in June 2005

Gene gun bombardment-mediated expression and translocation of EGFP-tagged GLUT4 in skeletal muscle fibres in vivo

scientific article

Glucose clearance is higher in arm than leg muscle in type 2 diabetes

scientific article

Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content.

scientific article

Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men.

scientific article published on 8 October 2015

Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle

scientific article published on 01 January 1998

Hormone-sensitive lipase as mediator of lipolysis in contracting skeletal muscle.

scientific article

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact

scientific article published on 30 June 2003

Imaging of insulin signaling in skeletal muscle of living mice shows major role of T-tubules

scientific article published in May 2006

Increased muscle glucose uptake after exercise. No need for insulin during exercise

scientific article published on 01 October 1985

Increased muscle glucose uptake during contractions: no need for insulin

scientific article published on 01 December 1984

Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial

scientific article published on 22 January 2015

Kinetics of glucose transport in rat muscle: effects of insulin and contractions

scientific article published on 01 July 1987

Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice: imaging analysis of GLUT4-enhanced green fluorescent protein vesicle dynamics

scientific article

Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists

scientific article published on 14 May 2020

Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

scientific article published on 18 September 2017

Muscle and liver glycogen, protein, and triglyceride in the rat. Effect of exercise and of the sympatho-adrenal system

scientific article published on 01 January 1984

Muscle ceramide content in man is higher in type I than type II fibers and not influenced by glycogen content.

scientific article

Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats

scientific article published on 17 January 2013

Only minor additional metabolic health benefits of high as opposed to moderate dose physical exercise in young, moderately overweight men.

scientific article published on 14 December 2013

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes.

scientific article published on September 2010

PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

scientific article published on 10 May 2019

Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.

scientific article published on 19 April 2005

Point: Counterpoint Glucose Phosphorylation is/ is not a Significant Barrier to Muscle Glucose Uptake By the Working Muscle

scientific article published on 14 November 2017

Pre-embedding staining of single muscle fibers for light and electron microscopy studies of subcellular organization

scientific article published on 01 January 1996

Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis

scientific article published in December 2005

Purinergic receptors expressed in human skeletal muscle fibres

scientific article

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

scientific article

Regulation and role of hormone-sensitive lipase in rat skeletal muscle

scientific article published in May 2004

Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

scientific article published on 27 March 2014

Subcellular localization of SV2 and other secretory vesicle components in PC12 cells by an efficient method of preembedding EM immunocytochemistry for cell cultures

scientific article published on 01 December 1996

The effect of exercise training on hormone-sensitive lipase in rat intra-abdominal adipose tissue and muscle

scientific article

The organization of the Golgi complex and microtubules in skeletal muscle is fiber type-dependent.

scientific article published in December 1999

Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men.

scientific article published on 25 January 2015

List of works by Thorkil Ploug

An optimized histochemical method to assess skeletal muscle glycogen and lipid stores reveals two metabolically distinct populations of type I muscle fibers

Anatomy of glucose transporters in skeletal muscle. Effects of insulin and contractions

Appetite regulation in overweight, sedentary men after different amounts of endurance exercise: a randomized controlled trial

Blood vessels and desmin control the positioning of nuclei in skeletal muscle fibers

Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise—a randomized controlled trial in overweight sedentary males

Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET.

Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation

Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation

Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers

Changes in peak fat oxidation in response to different doses of endurance training.

Compliance with physical exercise: using a multidisciplinary approach within a dose-dependent exercise study of moderately overweight men.

Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle

Contractions activate hormone-sensitive lipase in rat muscle by protein kinase C and mitogen-activated protein kinase

Contractions induce phosphorylation of the AMPK site Ser565 in hormone-sensitive lipase in muscle

Counterpoint: Glucose phosphorylation is not a significant barrier to glucose uptake by the working muscle

Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine

Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin.

Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men.

Disruption of microtubules in rat skeletal muscle does not inhibit insulin- or contraction-stimulated glucose transport

Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins

Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization.

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Ectopic Lipid Deposition Is Associated With Insulin Resistance in Postmenopausal Women

Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle

Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle

Effect of in vivo injection of cholera and pertussis toxin on glucose transport in rat skeletal muscle

Effect of intermittent fasting and refeeding on insulin action in healthy men.

Effect of prior immobilization on muscular glucose clearance in resting and running rats

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

Endurance TrainingPer SeIncreases Metabolic Health in Young, Moderately Overweight Men

Endurance training augments the stimulatory effect of epinephrine on oxygen consumption in perfused skeletal muscle

Excitatory amino acid transporters EAAT-1 and EAAT-2 in temporal lobe and hippocampus in intractable temporal lobe epilepsy

Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: a randomized study using FDG PET imaging.

Exploring the whereabouts of GLUT4 in skeletal muscle (review).

Expression of the synaptic vesicle proteins VAMPs/synaptobrevins 1 and 2 in non-neural tissues

Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy

Gene gun bombardment-mediated expression and translocation of EGFP-tagged GLUT4 in skeletal muscle fibres in vivo

Glucose clearance is higher in arm than leg muscle in type 2 diabetes

Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content.

Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men.

Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle

Hormone-sensitive lipase as mediator of lipolysis in contracting skeletal muscle.

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact

Imaging of insulin signaling in skeletal muscle of living mice shows major role of T-tubules

Increased muscle glucose uptake after exercise. No need for insulin during exercise

Increased muscle glucose uptake during contractions: no need for insulin

Independent effects of endurance training and weight loss on peak fat oxidation in moderately overweight men: a randomized controlled trial

Kinetics of glucose transport in rat muscle: effects of insulin and contractions

Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice: imaging analysis of GLUT4-enhanced green fluorescent protein vesicle dynamics

Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists

Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

Muscle and liver glycogen, protein, and triglyceride in the rat. Effect of exercise and of the sympatho-adrenal system

Muscle ceramide content in man is higher in type I than type II fibers and not influenced by glycogen content.

Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats

Only minor additional metabolic health benefits of high as opposed to moderate dose physical exercise in young, moderately overweight men.

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes.

PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.

Point: Counterpoint Glucose Phosphorylation is/ is not a Significant Barrier to Muscle Glucose Uptake By the Working Muscle

Pre-embedding staining of single muscle fibers for light and electron microscopy studies of subcellular organization

Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis

Purinergic receptors expressed in human skeletal muscle fibres

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

Regulation and role of hormone-sensitive lipase in rat skeletal muscle

Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation

Subcellular localization of SV2 and other secretory vesicle components in PC12 cells by an efficient method of preembedding EM immunocytochemistry for cell cultures

The effect of exercise training on hormone-sensitive lipase in rat intra-abdominal adipose tissue and muscle

The organization of the Golgi complex and microtubules in skeletal muscle is fiber type-dependent.

Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men.