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List of works by Dennis O. Scott

A new chemical tool for exploring the physiological function of the PDE2 isozyme

scientific article

A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats

scientific article published on 05 April 2006

Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles.

scientific article published on 6 August 2009

Comparison of in vitro BBMEC permeability and in vivo CNS uptake by microdialysis sampling

scientific article published in March 2002

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents

scientific article

Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor

scientific article published on 6 March 2012

Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist

scientific article

Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity

scientific article

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity

scientific article published on 28 September 2010

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

scientific article published on 26 January 2006

Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists ⬇️

scientific article published on February 23, 2012

Enzymatic formation and electrochemical characterization of multiply substituted glutathione conjugates of hydroquinone

scientific article published on 01 January 1993

Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies

scientific article

Excretion, metabolism, and pharmacokinetics of CP-945,598, a selective cannabinoid receptor antagonist, in rats, mice, and dogs

scientific article published on 29 August 2011

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters

scientific article published on 16 December 2016

Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

scientific article published in January 2003

Impact of genetic polymorphisms of cytochrome P450 2 C (CYP2C) enzymes on the drug metabolism and design of antidiabetics ⬇️

scientific article published on September 10, 2011

In silico modeling of nonspecific binding to human liver microsomes

scientific article published on 07 July 2008

In vivo microdialysis sampling coupled to liquid chromatography for the study of acetaminophen metabolism

scientific article published on 01 May 1990

In vivo microdialysis sampling for pharmacokinetic investigations

scientific article published on 01 March 1991

In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol

scientific article published on 01 March 1993

Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration.

scientific article

Intravenous microdialysis sampling in awake, freely-moving rats

scientific article published in April 1992

Investigation of the CNS penetration of a potent 5-HT2a receptor antagonist (MDL 100,907) and an active metabolite (MDL 105,725) using in vivo microdialysis sampling in the rat.

scientific article published on May 1998

In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.

scientific article published on 17 December 2016

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

scientific article published on 27 March 2012

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

scientific article published on 16 July 2012

Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design ⬇️

scientific article published on June 18, 2011

Microdialysis-perfusion sampling for the investigation of phenol metabolism

scientific article published on 01 January 1989

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists.

scientific article published on 2 November 2005

Passive drug permeation through membranes and cellular distribution.

scientific article published on 24 November 2016

Plasma pharmacokinetics of lactone and carboxylate forms of 20(S)-camptothecin in anesthetized rats

scientific article published on 01 October 1993

Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System

scientific article published on 12 September 2016

Quantification of a dual angiotensin I-converting enzyme-neutral endopeptidase inhibitor and the active thiol metabolite in dog plasma by high-performance liquid chromatography with ultraviolet absorbance detection

scientific article published on 01 August 1995

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.

scientific article

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.

scientific article published on 23 December 2015

Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

scientific article published on 22 October 2004

Species independence in brain tissue binding using brain homogenates

article

Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery.

scientific article published on 3 February 2010

Structure-based drug metabolism predictions for drug design.

scientific article published on 28 October 2009

Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators

scientific article

Towards a unified model of passive drug permeation I: origins of the unstirred water layer with applications to ionic permeation

scientific article published on 7 November 2013

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