List of works - Richard Locksley

A novel model for IFN-γ-mediated autoinflammatory syndromes.

scientific article

A two-step process for cytokine production revealed by IL-4 dual-reporter mice

scientific article

Activated type 2 innate lymphoid cells regulate beige fat biogenesis

scientific article

Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection

scientific article published in April 2002

Allergic inflammation--innately homeostatic

scientific article

Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter

scientific article published in August 2001

Asthma and allergic inflammation

scientific article

Asthma and the flu: a tricky two-step

scientific article

CD1, tuberculosis, and the evolution of major histocompatibility complex molecules

scientific article

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

scientific article

Chitin induces accumulation in tissue of innate immune cells associated with allergy

scientific article

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis ⬇️

scientific article published on September 14, 2011

Deletion of a coordinate regulator of type 2 cytokine expression in mice

scientific article

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

scientific article

Development of CD4+ effector T cells and susceptibility to infectious diseases

scientific article published in January 1998

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein

scientific article

Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.

scientific article published in September 1998

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse

scientific article

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity ⬇️

scientific article published on December 4, 2011

Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates

scientific article

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.

scientific article published on 10 April 2015

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

scientific article

Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection

scientific article

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

scientific article

Genetic analysis of basophil function in vivo.

scientific article published on 8 May 2011

Helper T cells regulate type-2 innate immunity in vivo

scientific article published in December 2002

I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis

scientific article

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity ⬇️

scientific article published on December 13, 2010

ILC2s – development, divergence, dispersal

scientific article published in 2022

Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine

scientific article

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

scientific article

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

scientific article published on October 1999

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

scientific article

Infectious (Non)tolerance--Frustrated Commensalism Gone Awry? ⬇️

scientific article published on May 1, 2012

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

scientific article

Innate immune responses in peptidoglycan recognition protein L-deficient mice

scientific article

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

scientific article published on June 2015

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

scientific article

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

scientific article

Lymphocyte development requires S-nitrosoglutathione reductase ⬇️

scientific article published on October 27, 2010

Marking and Quantifying IL-17A-Producing Cells In Vivo ⬇️

scientific article published on June 29, 2012

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

scientific article

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia

scientific article

Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection

scientific journal article

Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

scientific article

Pulmonary neuroendocrine cells amplify allergic asthma responses

scientific article published on 29 March 2018

Regulation of immune responses by tuft cells

scientific article published on 01 September 2019

Skin-resident innate lymphoid cells converge on a pathogenic effector state

scientific article published on 03 February 2021

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

scientific article

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

scientific article

T helper cell differentiation: on again, off again

scientific article

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

scientific article

Th2 cells: orchestrating barrier immunity

scientific article published on January 2004

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma

scientific article

Tissue immunity broadcasts near and far

scientific article published on 01 February 2020

Tissue signals imprint ILC2 identity with anticipatory function.

scientific article published on 10 September 2018

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development

scientific article

Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

scientific article

Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production

scientific article published in March 2004

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

scientific article

List of works by Richard Locksley

A novel model for IFN-γ-mediated autoinflammatory syndromes.

A two-step process for cytokine production revealed by IL-4 dual-reporter mice

Activated type 2 innate lymphoid cells regulate beige fat biogenesis

Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection

Allergic inflammation--innately homeostatic

Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter

Asthma and allergic inflammation

Asthma and the flu: a tricky two-step

CD1, tuberculosis, and the evolution of major histocompatibility complex molecules

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

Chitin induces accumulation in tissue of innate immune cells associated with allergy

Deletion of Syk in Neutrophils Prevents Immune Complex Arthritis ⬇️

Deletion of a coordinate regulator of type 2 cytokine expression in mice

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9

Development of CD4+ effector T cells and susceptibility to infectious diseases

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein

Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity ⬇️

Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

Genetic analysis of basophil function in vivo.

Helper T cells regulate type-2 innate immunity in vivo

I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity ⬇️

ILC2s – development, divergence, dispersal

Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

Infectious (Non)tolerance--Frustrated Commensalism Gone Awry? ⬇️

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

Innate immune responses in peptidoglycan recognition protein L-deficient mice

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

Lymphocyte development requires S-nitrosoglutathione reductase ⬇️

Marking and Quantifying IL-17A-Producing Cells In Vivo ⬇️

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia

Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection

Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

Pulmonary neuroendocrine cells amplify allergic asthma responses

Regulation of immune responses by tuft cells

Skin-resident innate lymphoid cells converge on a pathogenic effector state

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

T helper cell differentiation: on again, off again

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

Th2 cells: orchestrating barrier immunity

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma

Tissue immunity broadcasts near and far

Tissue signals imprint ILC2 identity with anticipatory function.

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development

Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice