List of works - Dries Knapen

A high throughput passive dosing format for the Fish Embryo Acute Toxicity test

scientific article published on 27 May 2015

Advancing the Zebrafish embryo test for endocrine disruptor screening using micro-injection: Ethinyl estradiol as a case study

scientific article published on 11 February 2019

Advancing the adverse outcome pathway framework-An international horizon scanning approach

scientific article published on June 2017

Adverse Outcome Pathway Networks I: Development and Applications.

scientific article published on 28 February 2018

Adverse Outcome Pathway Networks II: Network Analytics.

scientific article published on 28 February 2018

Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence.

scientific article

Adverse outcome pathways: a concise introduction for toxicologists

scientific article published on 28 June 2017

An AOP-based alternative testing strategy to predict the impact of thyroid hormone disruption on swim bladder inflation in zebrafish.

scientific article published on 21 April 2018

An ecotoxicological view on neurotoxicity assessment

scientific article published on 14 December 2018

Antioxidants reduce reactive oxygen species but not embryotoxicity in the metabolic Danio rerio test (mDarT).

scientific article published on 26 June 2017

Aquatic multi-species acute toxicity of (chlorinated) anilines: experimental versus predicted data

scientific article published on 15 July 2010

Assessing the impact of thermal acclimation on physiological condition in the zebrafish model

scientific article published on 8 August 2012

Assessment of aquatic experimental versus predicted and extrapolated chronic toxicity data of four structural analogues ⬇️

scientific article published on September 22, 2011

Bacterial gene profiling assay applied as an alternative method for mode of action classification: pilot study using chlorinated anilines

scientific article

Best practices for hybridization design in two-colour microarray analysis

scientific article published on 28 May 2009

Bioaccumulation of micropollutants and biomarker responses in caged carp (Cyprinus carpio)

article

Characterizing dose response relationships: Chronic gamma radiation in Lemna minor induces oxidative stress and altered polyploidy level.

scientific article

Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways

scientific article published on 16 October 2018

Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function

scientific article

Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction

scientific article published on 9 April 2015

Discrepancies in the acute versus chronic toxicity of compounds with a designated narcotic mechanism

scientific article published on 29 January 2012

Drought Induces Distinct Growth Response, Protection, and Recovery Mechanisms in the Maize Leaf Growth Zone.

scientific article

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

scientific article published on 22 April 2020

Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study

scientific article published on 02 March 2017

From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development

scientific article published on 10 December 2018

Gene expression profiling of three different stressors in the water flea Daphnia magna

scientific article

Gene transcription ontogeny of hypothalamic-pituitary-thyroid axis development in early-life stage fathead minnow and zebrafish.

scientific article

Gene transcription patterns and energy reserves in Daphnia magna show no nanoparticle specific toxicity when exposed to ZnO and CuO nanoparticles

scientific article published on 19 February 2015

Hypothermal and hyperthermal acclimation differentially modulate cadmium accumulation and toxicity in the zebrafish.

scientific article published on 18 January 2013

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part I: Fathead minnow.

scientific article published on 7 January 2016

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part II: Zebrafish.

scientific article published on 18 January 2016

Impaired swim bladder inflation in early life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid

scientific article published on 10 May 2017

Increased intestinal barrier function in the small intestine of formula-fed neonatal piglets

scientific article published on 01 December 2012

Incubation at 32.5°C and above causes malformations in the zebrafish embryo

scientific article published on 22 May 2015

Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish.

scientific article published on 27 January 2014

Long-term warm or cold acclimation elicits a specific transcriptional response and affects energy metabolism in zebrafish

scientific article published on 09 June 2010

Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges

scientific article published on 18 September 2021

Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing? ⬇️

scientific article published on May 28, 2012

Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity

scientific article published on 18 February 2013

Metallothionein gene and protein expression as a biomarker for metal pollution in natural gudgeon populations

scientific article published on 20 February 2007

Microarray-based annotation of the gut transcriptome of the migratory locust, Locusta migratoria.

scientific article published on August 2016

Microarray-based transcriptomic analysis of differences between long-term gregarious and solitarious desert locusts

scientific article

Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches

scientific article published on 30 October 2008

New metallothionein mRNAs in Gobio gobio reveal at least three gene duplication events in cyprinid metallothionein evolution

scientific article published in March 2005

Optimisation of the bovine whole in vitro embryo system as a sentinel for toxicity screening: a cadmium challenge

scientific article

Optimizing the Use of Zebrafish Feeding Trials for the Safety Evaluation of Genetically Modified Crops ⬇️

scientific article published on 23 March 2019

PFOS affects posterior swim bladder chamber inflation and swimming performance of zebrafish larvae

scientific article published on 27 October 2014

Physiological and molecular effect assessment versus physico-chemistry based mode of action schemes: Daphnia magna exposed to narcotics and polar narcotics.

scientific article

Physiological, biochemical, and genome-wide transcriptional analysis reveals that elevated CO2 mitigates the impact of combined heat wave and drought stress in Arabidopsis thaliana at multiple organizational levels

scientific article

Prioritization of contaminated watercourses using an integrated biomarker approach in caged carp.

scientific article published on 27 April 2016

Resistance to water pollution in natural gudgeon (Gobio gobio) populations may be due to genetic adaptation

scientific article published in April 2004

Structure-activity relationship assessment of four perfluorinated chemicals using a prolonged zebrafish early life stage test.

scientific article published on 15 December 2010

Temperature dependence of long-term cadmium toxicity in the zebrafish is not explained by liver oxidative stress: evidence from transcript expression to physiology

scientific article published on 13 October 2012

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

scientific article

The chronic toxicity of CuO nanoparticles and copper salt to Daphnia magna

scientific article published on 30 September 2014

The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution.

scientific article published on 29 July 2013

The effect of thyroperoxidase and deiodinase inhibition on anterior swim bladder inflation in the zebrafish

scientific article published on 22 April 2020

The potential of AOP networks for reproductive and developmental toxicity assay development.

scientific article published on 15 April 2015

The search for alternative aqueous film forming foams (AFFF) with a low environmental impact: physiological and transcriptomic effects of two Forafac(®) fluorosurfactants in turbot.

scientific article published on 30 April 2011

The structure of the fire fighting foam surfactant Forafac®1157 and its biological and photolytic transformation products

scientific article published on 2 June 2012

The uptake and elimination of ZnO and CuO nanoparticles in Daphnia magna under chronic exposure scenarios

scientific article published in January 2015

The uptake of ZnO and CuO nanoparticles in the water-flea Daphnia magna under acute exposure scenarios

scientific article published in November 2014

Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

scientific article published on 25 June 2020

Toxicity evaluation of perfluorooctane sulfonate (PFOS) in the liver of common carp (Cyprinus carpio).

scientific article

Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds.

scientific article

Transcriptional Analysis of The Adaptive Digestive System of The Migratory Locust in Response to Plant Defensive Protease Inhibitors

scientific article published on September 2016

Unraveling the mode of action of an obesogen: mechanistic analysis of the model obesogen tributyltin in the 3T3-L1 cell line.

scientific article published on 18 February 2013

Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation.

scientific article

β-Radiation Stress Responses on Growth and Antioxidative Defense System in Plants: A Study with Strontium-90 in Lemna minor

scientific article

List of works by Dries Knapen

A high throughput passive dosing format for the Fish Embryo Acute Toxicity test

Advancing the Zebrafish embryo test for endocrine disruptor screening using micro-injection: Ethinyl estradiol as a case study

Advancing the adverse outcome pathway framework-An international horizon scanning approach

Adverse Outcome Pathway Networks I: Development and Applications.

Adverse Outcome Pathway Networks II: Network Analytics.

Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence.

Adverse outcome pathways: a concise introduction for toxicologists

An AOP-based alternative testing strategy to predict the impact of thyroid hormone disruption on swim bladder inflation in zebrafish.

An ecotoxicological view on neurotoxicity assessment

Antioxidants reduce reactive oxygen species but not embryotoxicity in the metabolic Danio rerio test (mDarT).

Aquatic multi-species acute toxicity of (chlorinated) anilines: experimental versus predicted data

Assessing the impact of thermal acclimation on physiological condition in the zebrafish model

Assessment of aquatic experimental versus predicted and extrapolated chronic toxicity data of four structural analogues ⬇️

Bacterial gene profiling assay applied as an alternative method for mode of action classification: pilot study using chlorinated anilines

Best practices for hybridization design in two-colour microarray analysis

Bioaccumulation of micropollutants and biomarker responses in caged carp (Cyprinus carpio)

Characterizing dose response relationships: Chronic gamma radiation in Lemna minor induces oxidative stress and altered polyploidy level.

Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways

Deiodinase knockdown affects zebrafish eye development at the level of gene expression, morphology and function

Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction

Discrepancies in the acute versus chronic toxicity of compounds with a designated narcotic mechanism

Drought Induces Distinct Growth Response, Protection, and Recovery Mechanisms in the Maize Leaf Growth Zone.

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

Evaluating Complex Mixtures in the Zebrafish Embryo by Reconstituting Field Water Samples: A Metal Pollution Case Study

From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development

Gene expression profiling of three different stressors in the water flea Daphnia magna

Gene transcription ontogeny of hypothalamic-pituitary-thyroid axis development in early-life stage fathead minnow and zebrafish.

Gene transcription patterns and energy reserves in Daphnia magna show no nanoparticle specific toxicity when exposed to ZnO and CuO nanoparticles

Hypothermal and hyperthermal acclimation differentially modulate cadmium accumulation and toxicity in the zebrafish.

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part I: Fathead minnow.

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part II: Zebrafish.

Impaired swim bladder inflation in early life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid

Increased intestinal barrier function in the small intestine of formula-fed neonatal piglets

Incubation at 32.5°C and above causes malformations in the zebrafish embryo

Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish.

Long-term warm or cold acclimation elicits a specific transcriptional response and affects energy metabolism in zebrafish

Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges

Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing? ⬇️

Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity

Metallothionein gene and protein expression as a biomarker for metal pollution in natural gudgeon populations

Microarray-based annotation of the gut transcriptome of the migratory locust, Locusta migratoria.

Microarray-based transcriptomic analysis of differences between long-term gregarious and solitarious desert locusts

Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches

New metallothionein mRNAs in Gobio gobio reveal at least three gene duplication events in cyprinid metallothionein evolution

Optimisation of the bovine whole in vitro embryo system as a sentinel for toxicity screening: a cadmium challenge

Optimizing the Use of Zebrafish Feeding Trials for the Safety Evaluation of Genetically Modified Crops ⬇️

PFOS affects posterior swim bladder chamber inflation and swimming performance of zebrafish larvae

Physiological and molecular effect assessment versus physico-chemistry based mode of action schemes: Daphnia magna exposed to narcotics and polar narcotics.

Physiological, biochemical, and genome-wide transcriptional analysis reveals that elevated CO2 mitigates the impact of combined heat wave and drought stress in Arabidopsis thaliana at multiple organizational levels

Prioritization of contaminated watercourses using an integrated biomarker approach in caged carp.

Resistance to water pollution in natural gudgeon (Gobio gobio) populations may be due to genetic adaptation

Structure-activity relationship assessment of four perfluorinated chemicals using a prolonged zebrafish early life stage test.

Temperature dependence of long-term cadmium toxicity in the zebrafish is not explained by liver oxidative stress: evidence from transcript expression to physiology

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

The chronic toxicity of CuO nanoparticles and copper salt to Daphnia magna

The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution.

The effect of thyroperoxidase and deiodinase inhibition on anterior swim bladder inflation in the zebrafish

The potential of AOP networks for reproductive and developmental toxicity assay development.

The search for alternative aqueous film forming foams (AFFF) with a low environmental impact: physiological and transcriptomic effects of two Forafac(®) fluorosurfactants in turbot.

The structure of the fire fighting foam surfactant Forafac®1157 and its biological and photolytic transformation products

The uptake and elimination of ZnO and CuO nanoparticles in Daphnia magna under chronic exposure scenarios

The uptake of ZnO and CuO nanoparticles in the water-flea Daphnia magna under acute exposure scenarios

Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption

Toxicity evaluation of perfluorooctane sulfonate (PFOS) in the liver of common carp (Cyprinus carpio).

Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds.

Transcriptional Analysis of The Adaptive Digestive System of The Migratory Locust in Response to Plant Defensive Protease Inhibitors

Unraveling the mode of action of an obesogen: mechanistic analysis of the model obesogen tributyltin in the 3T3-L1 cell line.

Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation.

β-Radiation Stress Responses on Growth and Antioxidative Defense System in Plants: A Study with Strontium-90 in Lemna minor