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List of works by Malcolm G. Semple

1670O Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Chara

scientific article published in 2020

<sup>1</sup>H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization

scientific article published in 2022

A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study

scientific article published in 2022

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2

scientific article

A prenylated dsRNA sensor protects against severe COVID-19

scientific article

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

scientific article

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism

scientific article published on 14 October 2020

An evaluation of community assessment tools (CATs) in predicting use of clinical interventions and severe outcomes during the A(H1N1)pdm09 pandemic.

scientific article

Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages

scientific article published in 2022

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

scientific article published on 01 May 2022

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel

scientific article published on 20 April 2020

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel

Appropriate selection of convalescent plasma donors for COVID-19

scientific article published on 15 June 2020

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

scientific article published in 2023

Association of tiered restrictions and a second lockdown with COVID-19 deaths and hospital admissions in England: a modelling study

scientific article published on 23 December 2020

Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus.

scientific article published on 27 February 2017

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

scientific article published on 4 April 2024

Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients

scientific article published on 08 June 2020

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

scientific article published on 04 September 2020

CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections

scientific article published in December 2007

COVID-19 infection in children

scientific article published on 27 March 2020

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

scientific article

Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration

scientific article published on 01 May 2020

Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone

scientific article published on 01 August 2018

Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people

scientific article published in 2022

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study

scientific article published in 2021

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

scientific article

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

scholarly article by Rebecca J Shaw published in 2021

Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults

scientific article

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

scientific article published on 27 August 2020

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Clinical features and management of human monkeypox: a retrospective observational study in the UK

scientific article published on 24 May 2022

Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study

scientific article published in 2021

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study

scientific article published in 2021

Comment on: Dark without pressure retinal changes in a paediatric age group

scientific article published on 30 October 2020

Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data

scientific article (publication date: 2012)

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

scientific article published in 2022

Convalescent plasma therapy for persistent hepatitis E virus infection

scientific article published on 08 May 2019

Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014-2015 outbreak

scientific article published on 14 January 2016

Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK.

scientific article

Detection of Covid-19 in Children in Early January 2020 in Wuhan, China

scientific article published on 12 March 2020

Detection of HIV-1 RNA in factor VIII concentrate

scientific article published in May 1991

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

scientific article published on 01 October 2020

Detection, characterization, and enrollment of donors of Ebola convalescent plasma in Sierra Leone

scientific article

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

scientific article published in 2021

Development of processes allowing near real-time refinement and validation of triage tools during the early stage of an outbreak in readiness for surge: the FLU-CATs Study.

scientific article

Differences between asthmatics and nonasthmatics hospitalised with influenza A infection

scientific article published on 16 August 2012

Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study.

scientific article published on 20 August 2017

Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis.

scientific article published on 23 December 2004

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial.

scientific article

Ebola virus disease sequelae: a challenge that is not going away

scientific article

Ebola: Europe-Africa research collaborations

scientific article published in November 2015

Effect of ethnicity on care pathway and outcomes in patients hospitalized with influenza A(H1N1)pdm09 in the UK.

scientific article

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

scientific article published in 2023

Efficacy of Convalescent Plasma in Relation to Dose of Ebola Virus Antibodies

scientific article published on 14 November 2016

Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015.

scientific article published on December 2016

Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients

scientific article published in 2020

Evaluation and refinement of pandemic inFLUenza Community Assessment Tools

Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea

scientific article published on January 2016

Evolving Longitudinal Retinal Observations in a Cohort of Survivors of Ebola Virus Disease

scientific article published on 05 March 2020

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses

scientific article published in 2022

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

scientific article published on 28 April 2020

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

scientific article published on 22 May 2020

Fitting to the UK COVID-19 outbreak, short-term forecasts and estimating the reproductive number

scientific article published on 12 August 2020

Genetic mechanisms of critical illness in Covid-19

scientific article published on 11 December 2020

Genetic mechanisms of critical illness in Covid-19

scientific article published on 25 September 2020

HIV results in the frame

scientific article published in Nature

HIV, AIDS, and zidovudine

scientific article published in March 1992

HIV-1 RNA serum-load and resistant viral genotypes during early zidovudine therapy

scientific article published in The Lancet

HIV-1 plasma viraemia quantification: A non-culture measurement needed for therapeutic trials

article

Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave

scientific article published in 2021

Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: prospective cohort study.

scientific article

IFITM3 restricts the morbidity and mortality associated with influenza

scientific article

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

scientific article published in 2022

Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England

scientific article published on 09 June 2021

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

scholarly article by Ryan S Thwaites published in 2021

LBA60 Prospective data of &gt;20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK

scientific article published in 2021

Lack of suppression by ribavirin of HIV viraemia

scientific article

Left pulmonary artery sling presenting as unilateral echogenic lung on 20-week detailed antenatal ultrasound examination

scientific article published on 13 May 2003

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study

scientific article published on 20 October 2020

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

scientific article

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

scientific article published in 2021

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

scientific article published in 2022

Most human metapneumovirus and human respiratory syncytial virus in infant nasal secretions is cell free.

scientific article published in November 2007

Multimodal Imaging and Spatial Analysis of Ebola Retinal Lesions in 14 Survivors of Ebola Virus Disease

scientific article published in June 2018

Nasal Cytokines Associated With Householder Tobacco Smoking And HRSV Bronchiolitis

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

scientific article published in 2021

Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010

scientific article

Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016.

scientific article

Ocular Complications in Survivors of the Ebola Outbreak in Guinea

scientific article published on 29 July 2017

Open source clinical science for emerging infections

scientific article published in January 2014

Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.

scientific article

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study

scientific article published on 02 October 2020

Outcomes of COVID-19 Related Hospitalisation Among People with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: Prospective Observational Study

scientific article published in 2020

Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study

scientific article

Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study

scientific article published on 23 October 2020

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

scientific article published on 03 May 2022

Pathophysiology. Lessons from humanrespiratory syncytial virus bronchiolitisand acute wheezing episodes in infants

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study

scientific article published in 2021

Population variation in admission rates and duration of inpatient stay for bronchiolitis in England.

scientific article published on 5 December 2012

Post-Ebola Syndrome, Sierra Leone

scientific article

Pre-admission statin use and in-hospital severity of 2009 pandemic influenza A(H1N1) disease

scientific article

Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK.

scientific article

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

scientific article published in 2023

Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma

scientific article

Re: Shantha et al.: Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia (Ophthalmology. 2017;124:170-177).

scientific article published in March 2018

Reply to Lee and colleagues-Viral posterior uveitis.

scientific article published on 14 June 2017

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)

scientific article

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

scientific article published in 2021

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

scientific article published on 09 September 2020

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

scientific article published on 04 January 2022

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus

scientific article

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus

scientific article published in 2020

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

scientific article published in 2023

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

scientific article published on 31 March 2022

Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P.

scientific article

Stemming the tide of hospital admissions for bronchiolitis

scientific article published on 28 September 2015

Suction versus no suction for chest drain management

scientific article

Suction versus no suction for chest drain management.

scientific article

The UK hibernated pandemic influenza research portfolio: triggered for COVID-19

scientific article published on 15 May 2020

The UK's pandemic influenza research portfolio: a model for future research on emerging infections

scientific article published on 18 April 2019

The comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection.

scientific article

The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial

scientific article published in 2021

The value of open-source clinical science in pandemic response: lessons from ISARIC

scientific article published in 2021

Update on Cochrane data on paediatric respiratory diseases

scientific article

Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database

scientific article published on 02 July 2020

Visual Disability in Ebola Survivors.

scientific article published on 4 November 2017

Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study

scientific article published in 2021

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? - A harmonised, global longitudinal observational study

scientific article

What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol

scientific article published in 2021

Whole-genome sequencing reveals host factors underlying critical COVID-19

scientific article published in July 2022