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List of works by Allan R Brasier

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.

scientific article

8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors

scientific article published on 31 January 2014

A TNF-induced gene expression program under oscillatory NF-kappaB control

scientific article

A probabilistic approach to learn chromatin architecture and accurate inference of the NF-κB/RelA regulatory network using ChIP-Seq.

scientific article published on 14 June 2013

A structured approach to predictive modeling of a two-class problem using multidimensional data sets

scientific article

A three-component biomarker panel for prediction of dengue hemorrhagic fever.

scientific article published on February 2012

ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment

scientific article

Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling

scientific article published on 19 May 2022

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.

scientific article

An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation.

scientific article

Analysis and predictive modeling of asthma phenotypes.

scientific article published on January 2014

Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition.

scientific article published on 18 July 2015

Angiotensin II induces nuclear factor (NF)-kappaB1 isoforms to bind the angiotensinogen gene acute-phase response element: a stimulus-specific pathway for NF-kappaB activation

scientific article published on 01 January 2000

Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling

scientific article

Aortic remodeling after transverse aortic constriction in mice is attenuated with AT1 receptor blockade.

scientific article published on 18 July 2013

Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathways

scientific article published on 11 February 2013

Assessing and evaluating multidisciplinary translational teams: a mixed methods approach

scientific article

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.

scientific article

BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.

scientific article published on 11 January 2017

BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation

scientific article published on 28 October 2016

Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.

scientific article published on 10 December 2003

CDK9-Dependent Transcriptional Elongation in the Innate Interferon-Stimulated Gene Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells ⬇️

scientific article published on April 17, 2013

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways

scientific article

Central Role of the NFκB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-induced Airway Inflammation.

scientific article published on 28 March 2018

Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease

scientific article

Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies.

scientific article

Conclusions and future directions.

scientific article published on January 2014

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.

scientific article

Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation

scientific article published on August 2016

Deletion of NF-κB/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation

scientific article published on 17 August 2017

Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex

scientific article published on 01 May 2006

Discovery Proteomics and Nonparametric Modeling Pipeline in the Development of a Candidate Biomarker Panel for Dengue Hemorrhagic Fever ⬇️

scientific article published on February 23, 2012

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

scientific article published on 03 April 2018

Drug Discovery Targeting Bromodomain-Containing Protein 4.

scientific article

Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise.

scientific article

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.

scientific article published on 13 August 2017

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

scientific article published on 12 June 2018

Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling

scientific article published on 01 January 2019

Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Int

scientific article published on 11 November 2015

Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition.

scientific article published on 5 June 2017

Evolution of Multidisciplinary Translational Teams (MTTs): Insights for Accelerating Translational Innovations

scientific article

Examining troughs in the mass distribution of all theoretically possible tryptic peptides.

scientific article published on 09 August 2011

Expanding role of cyclin dependent kinases in cytokine inducible gene expression.

scientific article

Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection.

scientific article

Facilitation of Allergic Sensitization and Allergic Airway Inflammation by Pollen-Induced Innate Neutrophil Recruitment

scientific article published on 18 June 2015

Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles

scientific article

How cytokines co-occur across asthma patients: from bipartite network analysis to a molecular-based classification

journal article published in 2011

Hyperspectral confocal fluorescence imaging: exploring alternative multivariate curve resolution approaches.

scientific article published in March 2009

IKKε modulates RSV-induced NF-κB-dependent gene transcription

scientific article

IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome

scientific article published on 21 January 2014

Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.

scientific article published on February 2006

Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling.

scientific article

Identification of innate immune response endotypes in asthma: implications for personalized medicine

scientific article

IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.

scientific article published on March 2004

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

scientific article

Improved Mass Defect Model for Theoretical Tryptic Peptides ⬇️

scientific article published on March 7, 2012

Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

scientific article

Inferring genome-wide functional modulatory network: a case study on NF-κB/RelA transcription factor

scientific article

Inhibition of Proteasome Activity Blocks the Ability of TNFα to Down-Regulate Gi Proteins and Stimulate Lipolysis ⬇️

scientific article published on December 1, 2001

Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses.

scientific article published on 26 September 2013

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

scientific article

Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways

scientific article published on 02 June 2017

Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.

scientific article published on 13 January 2016

Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition.

scientific article published on 23 July 2016

Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice

scientific article published on 16 May 2013

Introduction to Clinical Proteomics

scientific article published on January 2016

Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation.

scientific article

Junín Virus Infection Activates the Type I Interferon Pathway in a RIG-I-Dependent Manner ⬇️

scientific article published on May 22, 2012

Junín virus pathogenesis and virus replication

scientific article

Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway.

scientific article published on 6 July 2004

Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement.

scientific article

MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II

scientific article

Measurement of Histone Methylation Dynamics by One-Carbon Metabolic Isotope Labeling and High-energy Collisional Dissociation Methylation Signature Ion Detection.

scientific article published on 17 August 2016

Measurement of the innate immune response in the airway

scientific article published on January 2014

Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

scientific article published on 8 April 2015

Model-based analysis of interferon-beta induced signaling pathway.

scientific article published on 19 August 2008

Modulation of gene expression regulated by the transcription factor NF-κB/RelA

scientific article published on 12 February 2014

Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines

scientific article

Multiple cis regulatory elements control RANTES promoter activity in alveolar epithelial cells infected with respiratory syncytial virus.

scientific article published on July 2001

Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer

scientific article published on 21 May 2014

Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.

scientific article published on 13 November 2015

NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence

scientific article published on 31 May 2001

NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival.

scientific article published in August 2001

NF-κB Mediates Mesenchymal Transition, Remodeling, and Pulmonary Fibrosis in Response to Chronic Inflammation by Viral RNA Patterns

scientific article

Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis

scientific article

Oxidant tone regulates RANTES gene expression in airway epithelial cells infected with respiratory syncytial virus. Role in viral-induced interferon regulatory factor activation.

scientific article published on 20 March 2001

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

scientific article published on 18 October 2016

Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women

scientific article published on 6 September 2016

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation.

scientific article published on 10 August 2017

Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines

scientific article

Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation

scientific article published on 01 October 2018

Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways.

scientific article published on 5 September 2017

Proteomics improves the prediction of burns mortality: results from regression spline modeling

scientific article

Qualification and Verification of Protein Biomarker Candidates.

scientific article published on January 2016

Quantification of Activated NF-κB/RelA Complexes Using ssDNA Aptamer Affinity – Stable Isotope Dilution—Selected Reaction Monitoring—Mass Spectrometry ⬇️

scientific article published on April 18, 2011

Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry ⬇️

scientific article published on February 15, 2013

Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification-Mass Spectrometry-based Protein-Protein Interaction Analysis

scientific article

RelA Ser276 Phosphorylation-Coupled Lys310 Acetylation Controls Transcriptional Elongation of Inflammatory Cytokines in Respiratory Syncytial Virus Infection ⬇️

scientific article published on September 7, 2011

RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes

scientific article

Repetitive TLR-3 activation in the lung induces skeletal muscle adaptations and cachexia

scientific article published on 13 February 2018

Reply: Protease Plays a Role in Ragweed Pollen-Induced Neutrophil Recruitment and Epithelial Barrier Disruption.

scientific article

Requirement of a novel upstream response element in respiratory syncytial virus-induced IL-8 gene expression.

scientific article

Respiratory Syncytial Virus Infection Induces Chromatin Remodeling to Activate Growth Factor and Extracellular Matrix Secretion Pathways

scientific article published on 26 July 2020

Respiratory Syncytial Virus Infection Triggers Epithelial HMGB1 Release as a Damage-Associated Molecular Pattern Promoting a Monocytic Inflammatory Response.

scientific article published on 17 August 2016

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2.

scientific article

Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2.

scientific article published on July 2005

Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter

scientific article

RhoA mediates angiotensin II-induced phospho-Ser536 nuclear factor kappaB/RelA subunit exchange on the interleukin-6 promoter in VSMCs

scientific article published on 07 September 2006

Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells

scientific article

Role of signal transducers and activators of transcription 1 and -3 in inducible regulation of the human angiotensinogen gene by interleukin-6

scientific article published on 01 March 2001

S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure

scientific article published on 18 August 2016

Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma

scientific article published in 2022

Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples

scientific article

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

scientific article published in April 2018

Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling.

scientific article

Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images. ⬇️

scientific article

Stochastic effects of multiple regulators on expression profiles in eukaryotes.

scientific article published on 8 December 2004

Strategies for Molecular Classification of Asthma Using Bipartite Network Analysis of Cytokine Expression ⬇️

scientific article published on October 1, 2012

Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infections

scientific article published on 3 March 2017

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases

scientific article

Systemic cytokine response profiles associated with respiratory virus-induced acute otitis media.

scientific article

Systems approaches to modeling chronic mucosal inflammation.

scientific article published on 21 October 2013

Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma

scientific article

TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells

scientific article

TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway.

scientific article published on 25 January 2007

Targeting Chromatin Remodeling in Inflammation and Fibrosis.

scientific article published on December 2016

The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams ⬇️

scientific article published on October 17, 2012

The IL-6 Trans-Signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar ⬇️

scientific article published on January 10, 2013

The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators.

scientific article

The NF-kappaB regulatory network

scientific article

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

scientific article published on 30 August 2018

The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.

scientific article published on 09 September 2008

The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3' UTR

scientific article

The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome

scientific article

Transcriptional stochasticity in gene expression.

scientific article published on 21 July 2005

Two-step cross-linking for analysis of protein-chromatin interactions.

scientific article

Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation.

scientific article

Unlocking proteomic heterogeneity in complex diseases through visual analytics

journal article published in 2015

Use of theoretical peptide distributions in phosphoproteome analysis

scientific article published on 19 June 2013

Variable selection methods for developing a biomarker panel for prediction of dengue hemorrhagic fever

scientific article

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

scientific article published on 14 July 2015

Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes

scientific article

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