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List of works by Geert Leroux-Roels

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

scientific article

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

scientific article

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

scientific article published on 16 December 2011

A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum

scientific article

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

scientific article published on 23 October 2017

A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C.

scientific article published on November 2003

A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations ⬇️

scientific article published on May 22, 2012

A randomized clinical trial to identify the optimal antigen and MF59® adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy adult and elderly subjects ⬇️

scientific article published on March 22, 2012

A randomized, observer-blind Phase Ib study to identify formulations and vaccine schedules of a trivalent Group B Streptococcus vaccine for use in non-pregnant and pregnant women

scientific article

AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial ⬇️

scientific article published on March 19, 2013

Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: randomised, controlled trials

scientific article published on 29 October 2013

An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers ⬇️

scientific article published on January 5, 2011

An adjuvanted, low-dose, pandemic influenza A (H5N1) vaccine candidate is safe, immunogenic, and induces cross-reactive immune responses in healthy adults.

scientific article

Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo

scientific article

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

scientific article published on 4 February 2015

Antibody Persistence and Booster Responses to Split-Virion H5N1 Avian Influenza Vaccine in Young and Elderly Adults

scientific article

Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial.

scientific article

Assessment of Parasite Liver-Stage Burden in Human-Liver Chimeric Mice

scientific article published on January 2015

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children

scientific article

Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment

scientific article published in December 2010

Broad Clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine

scientific article

Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

scientific article (publication date: December 2007)

Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

scientific article

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

scientific article

Characterization of HLA DR13-restricted CD4(+) T cell epitopes of hepatitis B core antigen associated with self-limited, acute hepatitis B.

scientific article published on December 2002

Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism

scientific article published in November 2009

Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses

scientific article

Comparison of qualitative (COBAS AMPLICOR HCV 2.0 versus VERSANT HCV RNA) and quantitative (COBAS AMPLICOR HCV monitor 2.0 versus VERSANT HCV RNA 3.0) assays for hepatitis C virus (HCV) RNA detection and quantification: impact on diagnosis and treat

scientific article

Comparison of serum humoral responses induced by oral immunization with the hepatitis B virus core antigen and the cholera toxin B subunit

scientific article published on 26 March 2008

Contamination of a recombinant hepatitis B virus nucleocapsid preparation with a human B-cell activator

scientific article published on 6 December 2006

Current status and progress of prepandemic and pandemic influenza vaccine development.

scientific article

Detection and characterization of a new metabolite of 17alpha-methyltestosterone

scientific article published on 24 August 2009

Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry

scientific article

Detection of mumps virus-specific memory B cells by transfer of peripheral blood mononuclear cells into immune-deficient mice

scientific article published on 25 June 2010

Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.

scientific article

Development of prophylactic and therapeutic vaccines against hepatitis C virus

scientific article

Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans

scientific article published on 14 August 2017

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

scientific article

Effects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: results from two randomized trials

scientific article published on 25 March 2014

Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines: randomized, double-blind study in malaria-naïve adults

scientific article published on January 2014

Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults

scientific article

Evidence for a relation between the viral load and genotype and hepatitis C virus-specific T cell responses

scientific article published on June 2004

Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice

scientific article published on 31 May 2010

Features of the CD4+ T-cell response in liver and peripheral blood of hepatitis C virus-infected patients with persistently normal and abnormal alanine aminotransferase levels

scientific article published in March 2002

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

scientific article

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

scientific article

Genetic and antigenic typing of seasonal influenza virus breakthrough cases from a 2008-2009 vaccine efficacy trial

scientific article published on 26 December 2013

Griffithsin has antiviral activity against hepatitis C virus

scientific article

HCV animal models: a journey of more than 30 years

scientific article published on 02 September 2009

HIV vaccines: can CD4+ T cells be of help?

scientific article published on 21 August 2012

Head-to-head comparison of pandemic influenza vaccines

scientific article

Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease

scientific article published in April 2015

Hepatitis B vaccine effectiveness in the face of global HBV genotype diversity

scientific article published on December 2011

Hepatitis B virus surface antigen suppresses the activation of monocytes through interaction with a serum protein and a monocyte-specific receptor

scientific article

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response

scientific article published on August 2014

Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

scientific article

Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus

scientific article

Immunogenicity and safety of a novel monovalent high-dose inactivated poliovirus type 2 vaccine in infants: a comparative, observer-blind, randomised, controlled trial

scientific article

Immunogenicity and safety of cell-derived MF59®-adjuvanted A/H1N1 influenza vaccine for children

scientific article

Immunogenicity and safety of different formulations of an adjuvanted glycoprotein D genital herpes vaccine in healthy adults ⬇️

scientific article published on February 22, 2013

Immunogenicity and tolerability of an MF59-adjuvanted, egg-derived, A/H1N1 pandemic influenza vaccine in children 6-35 months of age.

scientific article

Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis

scientific article published on 03 October 2016

Immunostimulatory potential of hepatitis B nucleocapsid preparations: lipopolysaccharide contamination should not be overlooked.

scientific article published on February 2005

Impact of adjuvants on CD4(+) T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial

scientific article published on 25 May 2016

Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization

scientific article

In vitro and in vivo metabolism studies of dimethazine

scientific article

In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

scientific article

Influenza symptoms and their impact on elderly adults: randomised trial of AS03-adjuvanted or non-adjuvanted inactivated trivalent seasonal influenza vaccines

scientific article

Influenza vaccines: T-cell responses deserve more attention

scientific article published on August 1, 2012

Influenza virus-specific antibody dependent cellular cytoxicity induced by vaccination or natural infection

scientific article published on 30 November 2016

LPS-binding protein and CD14-dependent attachment of hepatitis B surface antigen to monocytes is determined by the phospholipid moiety of the particles

scientific article published in September 2002

Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry

scientific article

Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice

scientific article

Long-Term Persistence of Cell-Mediated and Humoral Responses to A(H1N1)pdm09 Influenza Virus Vaccines and the Role of the AS03 Adjuvant System in Adults during Two Randomized Controlled Trials

scientific article

Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes

scientific article

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice

scientific article published on 24 November 2013

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

scientific article published on 28 December 2015

Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

scientific article

Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review

scientific article

Old and new adjuvants for hepatitis B vaccines

scientific article

Partial delipidation improves the T-cell antigenicity of hepatitis B virus surface antigen

scientific article

Persistence and immune memory to hepatitis B vaccine 20 years after primary vaccination of Thai infants, born to HBsAg and HBeAg positive mothers

scientific article

Persistence of antibodies 20 y after vaccination with a combined hepatitis A and B vaccine

scientific article

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain

scientific article published on June 2008

Polyfunctional CD4(+) T cell responses in HIV-1-infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine.

scientific article published on 21 May 2013

Prepandemic H5N1 influenza vaccine adjuvanted with AS03: a review of the pre-clinical and clinical data.

scientific article

Priming with AS03 A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: an open non-randomised extension of a double-blind randomised primary study.

scientific article

Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients

scientific article published on 16 September 2014

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

scientific article

Production, characterization and in vitro testing of HBcAg-specific VHH intrabodies

scientific article

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes

scientific article

Randomized Trial of the Immunogenicity and Safety of the Hepatitis B Vaccine Given in an Accelerated Schedule Coadministered with the Human Papillomavirus Type 16/18 AS04-Adjuvanted Cervical Cancer Vaccine ⬇️

scientific article published on July 6, 2011

Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness

scientific article

Response to publications by Heyward W et al. and Kuan R et al.: Clinical and cost-effectiveness analyses, respectively, of hepatitis B vaccination-Heplisav™ compared with Engerix-B(®) vaccine in adults

scientific article

Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication

scientific article (publication date: December 2008)

Safety and immunogenicity of a new Sabin inactivated poliovirus vaccine candidate produced on the PER.C6® cell-line: a phase 1 randomized controlled trial in adults

scientific article published on 11 November 2020

Safety and immunogenicity of an MF59-adjuvanted A/H1N1 pandemic influenza vaccine in children from three to seventeen years of age.

scientific article

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: a phase I/II randomized clinical study

scientific article published on 6 March 2014

Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity

scientific article

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

scientific article

Steroid metabolism in chimeric mice with humanized liver

scientific article

Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

scientific article published on 22 March 2016

Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG(®) KO Mice.

scientific article

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

scientific article

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

scientific article

The arginine-rich carboxy-terminal domain of the hepatitis B virus core protein mediates attachment of nucleocapsids to cell-surface-expressed heparan sulfate.

scientific article

The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV.

scientific article published on 14 August 2008

The nucleocapsid of the hepatitis B virus: a remarkable immunogenic structure

scientific article published on October 2003

The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione

scientific article

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma

scientific article

Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse

scientific article published on 10 July 2007

Unmet needs in modern vaccinology: adjuvants to improve the immune response

scientific article

Vaccine development

scientific article (publication date: August 2011)

Vaccine-induced HIV seropositivity: A problem on the rise ⬇️

scientific article published on April 1, 2011

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

scientific article

Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum

scientific article published on 22 November 2012

Viral apoptotic mimicry: an immune evasion strategy developed by the hepatitis B virus?

scientific article

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

scientific article

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