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List of works by Geert-Jan van Gemert

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

scientific article

A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexual-stage antigen, Pfs230.

scientific article published in July 2003

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase

scientific article

A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes

scientific article published on 21 December 2015

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines

scientific article published on 09 September 2016

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

scientific article published on 4 February 2015

Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates

scientific article published on 16 February 2012

Bacterial superglue enables easy development of efficient virus-like particle based vaccines

scientific article

Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice ⬇️

scientific article published on February 20, 2012

Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites

scientific article published on May 2006

Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens

scientific article published on 17 October 2017

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

scientific article

Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

scholarly article

Cytotoxic markers associate with protection against malaria in human volunteers immunized with Plasmodium falciparum sporozoites

scientific article

Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites ⬇️

scientific article published on December 9, 2011

Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species

scientific article published on July 2006

Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes

scientific article

Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection.

scientific article published on 21 May 2007

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells

scientific article

HGF/MET signalling protects Plasmodium-infected host cells from apoptosis.

scientific article

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites

scientific article published on May 2015

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

scientific article published on September 2008

Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

scientific article published on 17 October 2011

Inhibitory effect of TNF-α on malaria pre-erythrocytic stage development: influence of host hepatocyte/parasite combinations

scientific article (publication date: 4 March 2011)

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

scientific article

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

scientific article published on 23 December 2013

Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells

scientific article

Malaria infected mosquitoes express enhanced attraction to human odor

scientific article

Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production

scientific article published in August 2006

Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial

scientific article published on 13 September 2017

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice

scientific article published on 24 November 2013

Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites

scientific article published on 29 August 2015

NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections

scientific article published on 27 November 2012

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

scientific article published on 9 February 2014

Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum

scientific article (publication date: October 2006)

Plasmodium liver load following parenteral sporozoite administration in rodents

scientific article published on 9 October 2012

Protection against a malaria challenge by sporozoite inoculation

scientific article published on July 2009

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

scientific article published on 18 April 2013

Protective Efficacy Induced by Genetically Attenuated Mid-to-Late Liver-Stage Arresting Plasmodium berghei Δmrp2 Parasites

scientific article published on 13 June 2016

Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity

scientific article

Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled Trial

scientific article published on 28 December 2015

Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection

scientific article

Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR.

scientific article published on 6 September 2017

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

scientific article

Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial

scientific article

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria

scientific article

Sulfadoxine-pyrimethamine impairs Plasmodium falciparum gametocyte infectivity and Anopheles mosquito survival

scientific article published on 02 June 2010

The Plasmodium falciparum male gametocyte protein P230p, a paralog of P230, is vital for ookinete formation and mosquito transmission

scientific article published in Scientific Reports

The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania

scientific article (publication date: 29 November 2010)

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays

scientific article

Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility

scientific article

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

scientific article

Transgenic fluorescent Plasmodium cynomolgi liver stages enable live imaging and purification of Malaria hypnozoite-forms

scientific article

Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development

scientific article (publication date: May 2014)

Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes

scientific article (publication date: May 2014)

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

scientific article

Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes

scientific article published on 10 February 2016

Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

scientific article

Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development

scientific article published on 15 March 2016

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