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List of works by Manuela Simoni

A Mutation in the First Transmembrane Domain of the Lutropin Receptor Causes Male Precocious Puberty ⬇️

scientific article published on February 1, 1998

A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts.

scientific article published on 23 October 2009

A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle

scientific article published on 10 May 2005

A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineage

scientific article published on 19 February 2003

A search for circulating immunoglobulins blocking follicle-stimulating hormone action in male idiopathic infertility.

scientific article

Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action

scientific article published in May 2003

Age-related changes in plasma dehydroepiandrosterone sulphate, cortisol, testosterone and free testosterone circadian rhythms in adult men.

scientific article published in January 1988

An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice.

scientific article

Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women

article by Marlies E. Kevenaar et al published 2 March 2007 in Human Reproduction

Anti-Müllerian hormone in men with normal and reduced sperm concentration and men with maldescended testes

scientific article published on 18 April 2008

Aromatase expression in human peripheral blood leucocytes (PBLs) and in various tissues in primates: studies in elderly humans and cynomolgus monkeys

scientific article published on 17 September 2012

Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P)

scientific article

Biosimilar recombinant follicle stimulating hormones in infertility treatment.

scientific article published on 02 June 2014

Body fat content and testosterone pharmacokinetics determine gonadotropin suppression after intramuscular injections of testosterone preparations in normal men.

scientific article

CAG repeat length in the androgen receptor gene affects the risk of male infertility ⬇️

scientific article published on October 1, 2003

Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons

scientific article published on 11 March 2004

Central hypogonadotropic hypogonadism: genetic complexity of a complex disease

scientific article

Changes in endocrine profile and reproductive organs during puberty in the male marmoset monkey (Callithrix jacchus).

scientific article published in August 2006

Changes in seasonality of birth rates in Germany from 1951 to 1990.

scientific article published in November 1993

Chorionic gonadotrophin beta subunit mRNA but not luteinising hormone beta subunit mRNA is expressed in the pituitary of the common marmoset (Callithrix jacchus).

scientific article

Chorionic gonadotropin beta-subunit gene expression in the marmoset pituitary is controlled by steroidogenic factor 1, early growth response protein 1, and pituitary homeobox factor 1.

scientific article published on 13 September 2007

Circadian rhythm of plasma testosterone in men with idiopathic hypogonadotrophic hypogonadism before and during pulsatile administration of gonadotrophin-releasing hormone

scientific article published in January 1992

Clinical experience with azoospermia: aetiology and chances for spermatozoa detection upon biopsy

scientific article published on 28 June 2010

Clinical trial of transdermal testosterone and oral levonorgestrel for male contraception

scientific article published on 01 April 1999

Cloning and expression of cynomolgus monkey (Macaca fascicularis) gonadotropins luteinizing hormone and follicle-stimulating hormone and identification of two polymorphic sites in the luteinizing hormone β subunit

scientific article published in October 1999

Complete spermatogenesis in orthotopic but not in ectopic transplants of autologously grafted marmoset testicular tissue

scientific article published on 3 January 2008

Copy number variants in patients with severe oligozoospermia and Sertoli-cell-only syndrome.

scientific article

Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus?

scientific article published on 28 June 2018

Current status of the molecular diagnosis of Y-chromosomal microdeletions in the work-up of male infertility. Initiative for international quality control

scientific article published in July 1998

Distribution and function of FSH receptor genetic variants in normal men

scientific article (publication date: June 2002)

Does the gonadotrophic axis play a role in the pathogenesis of Sertoli-cell-only syndrome?

scientific article published in May 1997

EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013.

scientific article

EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal microdeletions. State of the art 2004

scientific article published on 01 August 2004

Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency ⬇️

scientific article published on July 10, 1997

Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice

scientific article published on 20 March 2012

Effects of acute hCG stimulation on serum INSL3 and 25-OH vitamin D in Klinefelter syndrome

scientific article published on 27 June 2020

Effects of antiandrogens and ethane dimethane sulphonate (EDS) on gene expression, free subunits, bioactivity and secretion of pituitary gonadotrophins in male rats

scientific article published in February 1993

Effects of chronic administration of the phosphodiesterase inhibitor vardenafil on serum levels of adrenal and testicular steroids in men with type 2 diabetes mellitus

scientific article

Elevated follicle-stimulating hormone levels and the chances for azoospermic men to become fathers after retrieval of elongated spermatids from cryopreserved testicular tissue

scientific article published in August 2006

Endogenous progesterone and the exogenous progestin norethisterone enanthate are associated with a proinflammatory profile in healthy men.

scientific article

Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice

scientific article published on 21 October 2019

Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus).

scientific article

FSHR polymorphism p.N680S mediates different responses to FSH in vitro

article

Follicle-Stimulating Hormone Receptor Gene Haplotype Distribution in Normozoospermic and Azoospermic Men

scientific article published in July 2005

Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause

article

Follicle-stimulating hormone receptor polymorphisms in women with normogonadotropic anovulatory infertility ⬇️

scientific article published on October 1, 2003

Follicle-stimulating-hormone receptor and twinning.

scientific article published in January 2001

Functional and clinical consequences of mutations in the FSH receptor.

scientific article published on December 1996

Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

scientific article

Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis

scientific article published on 19 September 2008

Gene polymorphisms in female reproduction

scientific article published in January 2014

Genomic checkpoints for exon 10 usage in the luteinizing hormone receptor type 1 and type 2.

scientific article published on 15 May 2007

Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males

scientific article published in September 2005

Hypothalamic and gonadal components of hypogonadism in boys with Prader-Labhart- Willi syndrome.

scientific article

Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling

scientific article published on 25 December 2020

Impaired recognition memory in male mice with a supernumerary X chromosome

scientific article published on 17 August 2008

In Vitro Sertoli Cell Bioassay of Follicle-Stimulating Hormone (FSH): Serum from Different Animal Species Alters the Morphology of Rat Sertoli Cells without Affecting Their Response to FSH

scientific article published in July 1994

In vitro bioassay for human serum follicle-stimulating hormone (FSH) based on L cells transfected with recombinant rat FSH receptor: validation of a model system.

scientific article published on November 1994

Inhibin B in male reproduction: pathophysiology and clinical relevance

scientific article

Inhibin B is a more sensitive marker of spermatogenetic damage than FSH in the irradiated non-human primate model

scientific article published in September 1999

Intratesticular testosterone is increased in men with Klinefelter syndrome and may not be released into the bloodstream owing to altered testicular vascularization– a preliminary report

scientific article published in March 2014

Is inhibin B a pharmacodynamic parameter for FSH in normal men?

scientific article published in June 2001

Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction

scientific article

KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice

scientific article published on 2 May 2013

Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells.

scientific article

LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling

scientific article

LHR splicing variants and gene expression in the marmoset monkey.

scientific article published on 30 August 2007

Laboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions

scientific article published in October 1999

Lessons Learned in Andrology: Back to the future: making children in bed (at the right time).

scientific article published in May 2014

Leydig cell tumor in an anabolic steroid abuser

scientific article published on 20 May 2013

Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone.

scientific article

Male 41, XXY* mice as a model for klinefelter syndrome: hyperactivation of leydig cells.

scientific article published on 28 April 2010

Male hypogonadism caused by homozygous deletion of exon 10 of the luteinizing hormone (LH) receptor: differential action of human chorionic gonadotropin and LH

scientific article published on 01 June 2000

Manifestation of Y-chromosomal deletions in the human testis: a morphometrical and immunohistochemical evaluation

scientific article published in September 2002

Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.

scientific article published on 04 February 2014

Meiosis in autologous ectopic transplants of immature testicular tissue grafted to Callithrix jacchus

scientific article published on 21 December 2005

Molecular cloning and functional characterization of endogenous recombinant common marmoset monkey (Callithrix jacchus) follicle-stimulating hormone

scientific article published on 2 November 2010

Molecular diagnosis of Y chromosome microdeletions in Europe: state-of-the-art and quality control.

scientific article

Molecular heterogeneity of serum follicle-stimulating hormone in hypogonadal patients before and during androgen replacement therapy and in normal men

scientific article published in August 1993

Molecular pathophysiology and clinical manifestations of gonadotropin receptor defects

scientific article published in May 1998

Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells

scientific article published on 25 May 2020

Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure.

scientific article published in October 2007

Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome

scientific article published in July 1999

Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms

scientific article published on 01 February 1999

Mutations of the G protein-coupled receptors of the hypothalamo-pituitary-gonadal axis. Where do we stand?

scientific article published on August 1, 1998

Natural transmission of a partial AZFb deletion of the Y chromosome over three generations: Case report

scientific article published in September 2002

New horizons for in vitro spermatogenesis? An update on novel three-dimensional culture systems as tools for meiotic and post-meiotic differentiation of testicular germ cells

scientific article published on 27 June 2009

Norethisterone enanthate has neither a direct effect on the testis nor on the epididymis: a study in adult male cynomolgus monkeys (Macaca fascicularis).

scientific article published in April 2005

Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype

scientific article published in September 2000

Partial deletions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesis

scientific article published on 21 October 2004

Pharmacokinetics and pharmacodynamics of injectable testosterone undecanoate in castrated cynomolgus monkeys (Macaca fascicularis) are independent of different oil vehicles

scientific article published in August 2005

Pharmacokinetics and pharmacodynamics of recombinant and urinary human FSH in the male monkey (Macaca fascicularis)

scientific article published in April 1994

Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background.

scientific article published on 09 September 2008

Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line

scientific article published in 2022

Polymorphism of human pituitary FSH: analysis of immunoreactivity and in vitro bioactivity of different molecular species

scientific article published in May 1994

Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility

scientific article

Prevalence of Y chromosome microdeletions in infertile men who consulted a tertiary care medical centre: the Münster experience.

scientific article

Prevalence of olfactory and other developmental anomalies in patients with central hypogonadotropic hypogonadism.

scientific article

Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment.

scientific article published on 14 November 2017

Reassembly of somatic cells and testicular organogenesis in vitro.

scientific article

Recombinant human follicle stimulating hormone for treatment of male idiopathic infertility: a randomized, double-blind, placebo-controlled, clinical trial

scientific article published in March 1998

Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men.

scientific article

Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart

scientific article

Report of the 7th european workshop on molecular and cellular endocrinology of the testis

scientific article published in September 1992

Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism.

scientific article published on December 2005

SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet

scientific article published on 16 March 2015

Self-adjusted postmenopausal hormone replacement therapy: effects on the biological and immunological profile of FSH and correlation to climacteric symptoms.

scientific article published in March 2002

Semi-annual seasonal pattern of serum thyrotropin in adults

scientific article published on 25 July 2019

Serum inhibin B in combination with serum follicle-stimulating hormone (FSH) is a more sensitive marker than serum FSH alone for impaired spermatogenesis in men, but cannot predict the presence of sperm in testicular tissue samples

scientific article published on 01 July 1999

Single-nucleotide polymorphisms in the promoter region influence the expression of the human follicle-stimulating hormone receptor

scientific article published in August 2005

Six months of daily treatment with vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial.

scientific article

Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice.

scientific article

Strong association between serum levels of leptin and testosterone in men.

scientific article published in August 1997

Telomerase in differentiated thyroid cancer: promoter mutations, expression and localization.

scientific article

Testosterone substitution with a new transdermal, hydroalcoholic gel applied to scrotal or non-scrotal skin: a multicentre trial

scientific article published in August 2005

Testosterone-Induced Prostate Growth Is Blocked by Co- and Preadministration of Norethisterone Enanthate in Castrated Cynomolgus Monkeys

scientific article published in 2012

The EAA International Quality Control Programme for Y-Chromosomal microdeletions. European Academy of Andrology

article published in 1998

The Follicle-Stimulating Hormone Receptor: Biochemistry, Molecular Biology, Physiology, and Pathophysiology* ⬇️

scientific article published on December 1, 1997

The calcium-to-phosphorous (Ca/P) ratio in the diagnosis of primary hyperparathyroidism and hypoparathyroidism: a multicentric study

scientific article published on 31 March 2020

The combination of genetic variants of the FSHB and FSHR genes affects serum FSH in women of reproductive age.

scientific article

The diagnostic value of calcitonin measurement in wash-out fluid from fine-needle aspiration of thyroid nodules in the diagnosis of medullary thyroid cancer.

scientific article published on September 2013

The distribution of FSH receptor isoforms is related to basal FSH levels in subfertile women with normal menstrual cycles

scientific article

The prognostic value of miRNA146a in follicular thyroid carcinoma

scientific article published on 28 August 2013

Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis

scientific article published on 02 October 2014

Tissue expression of the nuclear progesterone receptor in male non-human primates and men.

scientific article

Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: Case report

scientific article published in September 1999

Twenty-four-hour pattern of plasma SHBG, total proteins and testosterone in young and elderly men

scientific article published in October 1988

Unraveling the fertility knot in World Health Organization type 2 anovulatory women: another step toward a pharmacogenetic treatment choice

scientific article published in April 2015

Very high prevalence of ultrasound thyroid scan abnormalities in healthy volunteers in Modena, Italy

scientific article published on 12 April 2013

Y-chromosomal microdeletions and partial deletions of the Azoospermia Factor c (AZFc) region in normozoospermic, severe oligozoospermic and azoospermic men in Sri Lanka.

scientific article

cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene.

scientific article published on June 1997

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