Search filters

List of works by Carlo Leonetti

156 DNA damage induced by camptothecins is stabilized by G-quadruplex ligands

334 POSTER Combination of c-myc and bci-2 antisense oligonucleotides with docetaxel is highly effective in vitro and in vivo on hormone-refractory prostate cancer

430 POSTER Telomere Damage promotes antitumoral activity of the G-quadruplex ligand RHPS4

441 POSTER The G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

scientific article

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

scientific article published on 07 October 2013

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides

scientific article published on 28 August 2014

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib

scientific article

AN EXPERIMENTAL STUDY IN NUDE MICE ON THE ELECTROMAGNETIC DIAGNOSIS OF TUMOURS

Alpha-tocopherol protects against cisplatin-induced toxicity without interfering with antitumor efficacy.

scientific article

Antibody-drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin

scientific article published on December 2013

Antisense oligodeoxynucleotides for urokinase-plasminogen activator receptor have anti-invasive and anti-proliferative effects in vitro and inhibit spontaneous metastases of human melanoma in mice

scientific article published on May 2004

Antitumor Efficacy of bcl-2 and c-myc Antisense Oligonucleotides in Combination with Cisplatin in Human Melanoma Xenografts: Relevance of the Administration Sequence

scientific article published on 01 March 2005

Antitumor and antimetastatic effects of dacarbazine combined with cyclophosphamide and interleukin-2 in Lewis lung carcinoma (3LL)

scientific article published on 01 December 1995

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells

scientific article

B11. Efficacy and mechanism of action of NCX 4040, a NO-donating acetyl salicylic acid derivative, as anticancer drug or sensitizing agent of conventional chemotherapeutic agents

scientific article published in 2007

Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity.

scientific article

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

scientific article

Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

scientific article published on 4 August 2010

Che-1 activates XIAP expression in response to DNA damage

scientific article

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

scientific article

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

scientific article published on 9 October 2018

Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains

scientific article published on 19 June 2020

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site

scientific article published in March 2002

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

scientific article published on 25 February 2011

Different effects of sequential combinations ofN-methylformamide with 5-fluorouracil on human colon carcinoma cells growing in nude mice

scientific article published on 01 January 1991

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.

scientific article published on 3 September 2015

Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model

scientific article

Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas

scientific article published on 18 April 2011

Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models

scientific article

Efficacy of a nitric oxide-releasing nonsteroidal anti-inflammatory drug and cytotoxic drugs in human colon cancer cell lines in vitro and xenografts

scientific article (publication date: April 2006)

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft

scientific article

Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line

scientific article published on 01 June 2001

Enhanced anti-tumor effects with microencapsulated c-myc antisense oligonucleotide.

scientific article published in October 1999

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article published on 5 February 2015

Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid

scientific article published on 18 September 2012

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

scientific article published on 11 December 2013

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

scientific article

From single gene analysis to single cell profiling: a new era for precision medicine

scientific article published on 05 March 2020

Functional role of α4β1 and α5β1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells ⬇️

scientific article published on 01 July 1997

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

scientific article

Harnessing Omics Approaches on Advanced Preclinical Models to Discovery Novel Therapeutic Targets for the Treatment of Metastatic Colorectal Cancer

scientific article published on 08 July 2020

Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion

scientific article

IL-2 reverses the inhibition of cytotoxic T-cell responses induced by 5-(3,3′ dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) in vitro

article

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article

In vitro and in vivo antitumor efficacy of docetaxel and sorafenib combination in human pancreatic cancer cells

scientific article published on September 2010

In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines

scientific article

In vitro and in vivo inhibition of SK-N-MC neuroblastoma growth using cyclic nucleotide phosphodiesterase inhibitors

scientific article

In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors

scientific article published on July 2004

Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.

scientific article published on 8 May 2013

Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma

scientific article published on 29 June 2006

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation.

scientific article published on May 1998

Liposomes containing zoledronic acid: A new opportunity against cancer

Lonidamine causes inhibition of angiogenesis-related endothelial cell functions

scientific article

Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models

scientific article published on February 2011

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers

scientific article

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

scientific article

N-methylformamide induces changes on adhesive properties and lung-colonizing potential of M14 melanoma cells.

scientific article

NCX 4040, an NO-donating acetylsalicylic acid derivative: efficacy and mechanisms of action in cancer cells

scientific article published on 22 April 2008

Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes

scientific article published on 29 March 2011

Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy.

scientific article

New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study

scientific article

New strategies based on zoledronic acid/tipifarnib combination in the therapy of prostate cancer

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

Oncosuppressive effects of telosome protein inhibition

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

scientific article published on 30 August 2010

Patient-derived xenografts: a relevant preclinical model for drug development

scientific article

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

scientific article published on 13 April 2016

Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent

scientific article

Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide

scientific article published on 8 November 2005

Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis

article

Potentiation of the antitumoral activity of gemcitabine and paclitaxel in combination on human breast cancer cells

scientific article

R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation

scientific article published on May 2007

Ras inhibition amplifies cisplatin sensitivity of human glioblastoma

scientific article

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

scientific article published on 15 May 2011

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown

scientific article

Self-assembly nanoparticles for the delivery of bisphosphonates into tumors

scientific article published on 3 November 2010

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

scientific article published on 13 July 2009

Synergism between 5-fluorouracil and N-methylformamide in HT29 human colon cancer line

scientific article published on March 1990

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

scientific article

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

scientific article

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer

scientific article published on 24 August 2015

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities.

scientific article

Targeting different signaling pathways with antisense oligonucleotides combination for cancer therapy.

scientific article published on January 2007

Telomerase as a new target for the treatment of hormone-refractory prostate cancer

scientific article published in September 2004

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

scientific article

Temozolomide reduces the metastatic potential of lewis lung carcinoma (3LL) in mice: Role of α-6 integrin phosphorylation

scientific article published on 01 January 1995

The future of antisense therapy: combination with anticancer treatments

scientific article published on September 2003

Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer

scientific article

Transferrin-Targeted Nanoparticles Containing Zoledronic Acid as a Potential Tool to Inhibit Glioblastoma Growth

scientific article published on April 2016

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo

scientific article

Paulina is supported by:

About Paulina

Help