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List of works by Manuela Porru

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

scientific article

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

scientific article published on 07 October 2013

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides

scientific article published on 28 August 2014

Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth

scientific article published in PLoS ONE

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells

scientific article

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

scientific article published on 20 July 2017

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

scientific article published on 17 July 2019

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

scientific article published on 9 October 2018

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance

scientific article published on 24 May 2019

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

scientific article published on 25 February 2011

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.

scientific article published on 3 September 2015

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

scientific article

Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models

scientific article

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article published on 5 February 2015

Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid

scientific article published on 18 September 2012

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

scientific article published on 11 December 2013

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

scientific article

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.

scientific article

Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

scientific article published on 16 November 2021

HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma

scientific article published on 14 December 2018

Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion

scientific article

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article

Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.

scientific article published on 8 May 2013

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid

scientific article

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

scientific article

Nanotechnologies to use zoledronic acid as a potent antitumoral agent

New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study

scientific article

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

scientific article published on 30 August 2010

Patient-derived xenografts: a relevant preclinical model for drug development

scientific article

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

scientific article published on 15 May 2011

Self-assembly nanoparticles for the delivery of bisphosphonates into tumors

scientific article published on 3 November 2010

Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.

scientific article published on February 2015

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

scientific article published on 13 July 2009

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

scientific article published on 01 April 2019

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

scientific article published on 29 December 2015

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer

scientific article published on 24 August 2015

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities.

scientific article

Transferrin-Targeted Nanoparticles Containing Zoledronic Acid as a Potential Tool to Inhibit Glioblastoma Growth

scientific article published on April 2016

Xenograft as In Vivo Experimental Model

scientific article published in January 2018

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo

scientific article

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