List of works - Jorma Hinkula

A novel DNA adjuvant, N3, enhances mucosal and systemic immune responses induced by HIV-1 DNA and peptide immunizations

article

A novel class of anti-HIV agents with multiple copies of enfuvirtide enhances inhibition of viral replication and cellular transmission in vitro

scientific article (publication date: 2012)

Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells

scientific article published on 22 September 2011

Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin.

scientific article published on September 2005

Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.

scientific article published on 26 December 2007

Antibody-dependent cellular cytotoxicity to clinical isolates of HIV-1 and SIVcpz: comparison of humans and chimpanzees

article

Antiretroviral therapy does not induce HIV type 1-specific neutralizing activity against autologous HIV type 1 isolates

article

Assessment of mucosal immunity to HIV-1.

scientific article published on April 2010

Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions

scientific article published on 25 June 2013

Bone Marrow Dendritic Cells Internalize Live RF-81 Bovine Rotavirus and Rotavirus-like Particles (RF 2/6-GFP-VLP and RF 8*2/6/7-VLP) But are Only Activated by Live Bovine Rotavirus

scientific article published in June 2007

Candidate HIV-1 gp140ΔV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge

article

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients

scientific article published in May 1998

Choosing CCR5 or Rev siRNA in HIV-1

scientific article published on 01 March 2003

Complement opsonization of HIV-1 enhances the uptake by dendritic cells and involves the endocytic lectin and integrin receptor families

scientific article published on 11 August 2011

Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells

scientific article published on 24 April 2013

Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3

scientific article published on 24 September 2014

Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

scientific article

Cross-clade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH.

scientific article

DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity.

scientific article published on 11 June 2007

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.

scientific article

Demonstration of neutralizing mucosal IgA response to intranasal HIV-1 env DNA vaccines with or without the V3 glycosylation site

scientific article published on 01 January 2004

Effective construction of DNA vaccines against variable influenza genes by homologous recombination.

scientific article

Efficient expression of recombinant human monoclonal antibodies in Drosophila S2 cells

scientific article

Elimination of HIV-1 infection by treatment with a doxorubicin-conjugated anti-envelope antibody.

scientific article

Endocine™, N3OA and N3OASq; three mucosal adjuvants that enhance the immune response to nasal influenza vaccination

scientific article published on 8 August 2013

Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen.

scientific article

Enhanced immune responses after DNA vaccination with combined envelope genes from different HIV-1 subtypes

scientific article published in October 2002

Epitope mapping of the HIV-1 gag region with monoclonal antibodies

scientific article published on 01 May 1990

Evaluation of immunogenicity and efficacy of combined DNA and adjuvanted protein vaccination in a human immunodeficiency virus type 1/murine leukemia virus pseudotype challenge model

scientific article published on 13 November 2006

Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses

scientific article published on 01 November 2008

Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers

article

Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

scientific article

Genetic immunization is augmented by murine polyomavirus VP1 pseudocapsids ⬇️

scientific article published on June 2, 2003

Genetic immunization with multiple HIV-1 genes provides protection against HIV-1/MuLV pseudovirus challenge in vivo.

scientific article published on January 2004

HIV subtypes and recombination strains--strategies for induction of immune responses in man.

scientific article

HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV.

scientific article

HPV-16 L1 genes with inactivated negative RNA elements induce potent immune responses

scientific article published in April 2004

Human antibodies from phage libraries: neutralizing activity against human immunodeficiency virus type 1 equally improved after expression as Fab and IgG in mammalian cells.

scientific article published on December 1996

Human immunodeficiency virus type 1 p24 production and antigenic variation in tissue culture of isolates with various growth characteristics.

scientific article

Immune responses but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts

scientific article published on 01 October 1998

Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology.

scientific article

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

scientific article

Immunization with HIV protease peptides linked to syngeneic erythrocytes.

scientific article published on 18 April 2007

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits

scientific article published on 01 September 2000

Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration

scientific article

Immunoglobulin V regions and epitope mapping of a murine monoclonal antibody against p24 core protein of HIV-1.

scientific article published in April 1992

Immunological cross-reactivity against a drug mutated HIV-1 protease epitope after DNA multi-CTL epitope construct immunization.

scientific article published on 18 August 2005

Impaired NK Cell Activation and Chemotaxis toward Dendritic Cells Exposed to Complement-Opsonized HIV-1.

scientific article published on 8 July 2015

Increased generation of HIV-1 gp120-reactive CD8+ T cells by a DNA vaccine construct encoding the chemokine CCL3.

scientific article

Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals

scientific article published on 01 March 2008

Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes

scientific article published on 29 December 2009

Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells.

scientific article published in November 2002

Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes

scientific article published in November 1999

Induction of specific T-cell responses in HIV infection

article

Inhibition of viral replication by monoclonal antibodies directed against human immunodeficiency virus gp120

scientific article published on September 1, 1992

Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks in Sweden: a cross-sectional study following a mass vaccination campaign

scientific article

Interactions of single and combined human immunodeficiency virus type 1 (HIV-1) DNA vaccines

scientific article published in May 2001

Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.

scientific article

Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing Flagellin in Aging In- and Outbred Mice

scientific article published on 16 July 2019

Long-term immunotherapy in HIV infection, combined with short-term antiretroviral treatment

scientific article published on 01 August 1999

Maternal immune status influences HIV-specific immune responses in pups after DNA prime protein boost using mucosal adjuvant

scientific article published on 16 September 2008

Mimicking the humoral immune response in vitro results in antigen-specific isotype switching supported by specific autologous T helper cells: generation of human HIV-1-neutralizing IgG monoclonal antibodies from naive donors

scientific article published on 01 March 1995

Monoclonal antibodies to conserved regions of the major core protein (gag24) of HIV-1 and HIV-2.

scientific article published in January 1991

Monoclonal antibodies to p24-core protein of HIV-1 mediate ADCC and inhibit virus spread in vitro

scientific article published in March 1995

Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate

article

Multi-subtype gp160 DNA immunization induces broadly neutralizing anti-HIV antibodies.

scientific article published in July 2004

Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery

scientific article

Murine models for HIV vaccination and challenge.

scientific article published on February 2008

Mycobacterium tuberculosis infection interferes with HIV vaccination in mice

scientific article

NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients

scientific article published on 01 November 2009

NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients

scientific article published on 29 September 2011

New tools for the herpes virologist

scientific article published on 01 January 1988

Nucleic acid vaccination with HIV regulatory genes

scientific article published on 01 November 1995

Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses

scientific article published on 01 June 1997

Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice

scientific article published on 25 June 2008

Performance of eHealth data sources in local influenza surveillance: a 5-year open cohort study.

scientific article

Phenotypes of placental-type alkaline phosphatase in seminoma sera as defined by monoclonal antibodies

scientific article published on 01 April 1986

Primary murine cells as a model for HIV-1 infection.

scientific article published on April 2004

Production of a murine monoclonal antibody with anti-hiv-1 neutralizing properties ⬇️

scientific article published on January 1, 1991

Protective efficacy of a DNA influenza virus vaccine is markedly increased by the coadministration of a Schiff base-forming drug.

scientific article

Responses of mice immunized with a DNA vaccine encoding carcinoembryonic antigen (CEA)

article

Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.

scientific article

Safety and immunogenicity, after nasal application of HIV-1 DNA gagp37 plasmid vaccine in young mice

scientific article published on 25 April 2008

Seroreactivity to HIV-1 V3 Subtypes A to H Peptides of Argentinian HIV-Positive Sera ⬇️

scientific article published on February 1, 1998

Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41.

scientific article published in September 2002

Signal sequence deletion and fusion to tetanus toxoid epitope augment antitumor immune responses to a human carcinoembryonic antigen (CEA) plasmid DNA vaccine in a murine test system

scientific article published on 01 May 2003

Study of the adjuvant activity of new MDP derivatives and purified saponins and their influence on HIV-1 replication in vitro

scientific article published on 01 August 1997

Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production.

scientific article published in January 2000

The intranasal adjuvant Endocine™ enhances both systemic and mucosal immune responses in aged mice immunized with influenza antigen

scientific article published on 03 March 2017

Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals

article

Vpu and Tsg101 regulate intracellular targeting of the human immunodeficiency virus type 1 core protein precursor Pr55gag

scientific article published on April 2006

List of works by Jorma Hinkula

A novel DNA adjuvant, N3, enhances mucosal and systemic immune responses induced by HIV-1 DNA and peptide immunizations

A novel class of anti-HIV agents with multiple copies of enfuvirtide enhances inhibition of viral replication and cellular transmission in vitro

Accumulation and activation of natural killer cells in local intraperitoneal HIV-1/MuLV infection results in early control of virus infected cells

Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin.

Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.

Antibody-dependent cellular cytotoxicity to clinical isolates of HIV-1 and SIVcpz: comparison of humans and chimpanzees

Antiretroviral therapy does not induce HIV type 1-specific neutralizing activity against autologous HIV type 1 isolates

Assessment of mucosal immunity to HIV-1.

Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions

Bone Marrow Dendritic Cells Internalize Live RF-81 Bovine Rotavirus and Rotavirus-like Particles (RF 2/6-GFP-VLP and RF 8*2/6/7-VLP) But are Only Activated by Live Bovine Rotavirus

Candidate HIV-1 gp140ΔV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients

Choosing CCR5 or Rev siRNA in HIV-1

Complement opsonization of HIV-1 enhances the uptake by dendritic cells and involves the endocytic lectin and integrin receptor families

Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells

Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3

Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

Cross-clade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH.

DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity.

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.

Demonstration of neutralizing mucosal IgA response to intranasal HIV-1 env DNA vaccines with or without the V3 glycosylation site

Effective construction of DNA vaccines against variable influenza genes by homologous recombination.

Efficient expression of recombinant human monoclonal antibodies in Drosophila S2 cells

Elimination of HIV-1 infection by treatment with a doxorubicin-conjugated anti-envelope antibody.

Endocine™, N3OA and N3OASq; three mucosal adjuvants that enhance the immune response to nasal influenza vaccination

Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen.

Enhanced immune responses after DNA vaccination with combined envelope genes from different HIV-1 subtypes

Epitope mapping of the HIV-1 gag region with monoclonal antibodies

Evaluation of immunogenicity and efficacy of combined DNA and adjuvanted protein vaccination in a human immunodeficiency virus type 1/murine leukemia virus pseudotype challenge model

Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses

Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers

Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Effects on Its Immunogenic Performance in DNA-Immunized Mice.

Genetic immunization is augmented by murine polyomavirus VP1 pseudocapsids ⬇️

Genetic immunization with multiple HIV-1 genes provides protection against HIV-1/MuLV pseudovirus challenge in vivo.

HIV subtypes and recombination strains--strategies for induction of immune responses in man.

HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV.

HPV-16 L1 genes with inactivated negative RNA elements induce potent immune responses

Human antibodies from phage libraries: neutralizing activity against human immunodeficiency virus type 1 equally improved after expression as Fab and IgG in mammalian cells.

Human immunodeficiency virus type 1 p24 production and antigenic variation in tissue culture of isolates with various growth characteristics.

Immune responses but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts

Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology.

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Immunization with HIV protease peptides linked to syngeneic erythrocytes.

Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits

Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration

Immunoglobulin V regions and epitope mapping of a murine monoclonal antibody against p24 core protein of HIV-1.

Immunological cross-reactivity against a drug mutated HIV-1 protease epitope after DNA multi-CTL epitope construct immunization.

Impaired NK Cell Activation and Chemotaxis toward Dendritic Cells Exposed to Complement-Opsonized HIV-1.

Increased generation of HIV-1 gp120-reactive CD8+ T cells by a DNA vaccine construct encoding the chemokine CCL3.

Individuals with selective IgA deficiency resolve rotavirus disease and develop higher antibody titers (IgG, IgG1) than IgA competent individuals

Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes

Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells.

Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes

Induction of specific T-cell responses in HIV infection

Inhibition of viral replication by monoclonal antibodies directed against human immunodeficiency virus gp120

Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks in Sweden: a cross-sectional study following a mass vaccination campaign

Interactions of single and combined human immunodeficiency virus type 1 (HIV-1) DNA vaccines

Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.

Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing Flagellin in Aging In- and Outbred Mice

Long-term immunotherapy in HIV infection, combined with short-term antiretroviral treatment

Maternal immune status influences HIV-specific immune responses in pups after DNA prime protein boost using mucosal adjuvant

Mimicking the humoral immune response in vitro results in antigen-specific isotype switching supported by specific autologous T helper cells: generation of human HIV-1-neutralizing IgG monoclonal antibodies from naive donors

Monoclonal antibodies to conserved regions of the major core protein (gag24) of HIV-1 and HIV-2.

Monoclonal antibodies to p24-core protein of HIV-1 mediate ADCC and inhibit virus spread in vitro

Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate

Multi-subtype gp160 DNA immunization induces broadly neutralizing anti-HIV antibodies.

Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery

Murine models for HIV vaccination and challenge.

Mycobacterium tuberculosis infection interferes with HIV vaccination in mice

NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients

NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients

New tools for the herpes virologist

Nucleic acid vaccination with HIV regulatory genes

Nucleic acid vaccination with HIV regulatory genes: a combination of HIV-1 genes in separate plasmids induces strong immune responses

Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice

Performance of eHealth data sources in local influenza surveillance: a 5-year open cohort study.

Phenotypes of placental-type alkaline phosphatase in seminoma sera as defined by monoclonal antibodies

Primary murine cells as a model for HIV-1 infection.

Production of a murine monoclonal antibody with anti-hiv-1 neutralizing properties ⬇️