List of works - Hans-Martin Jäck

A B220(-), CD19(-) population of B cells in the peripheral blood of quasimonoclonal mice.

scientific article published on January 2000

A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.

scientific article

A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.

scientific article published on 19 May 2017

A facile method to increase titers of miRNA-encoding retroviruses by inhibition of the RNaseIII enzyme Drosha.

scientific article published on 29 December 2010

A gene regulation system with four distinct expression levels

scientific article published on August 2006

A new staining protocol for detection of murine antibody-secreting plasma cell subsets by flow cytometry

scientific article published on 13 June 2017

A web platform for the network analysis of highthroughput data in melanoma and its use to investigate mechanisms of resistance to anti-PD1 immunotherapy.

scientific article published on 2 February 2018

APOBEC3 enzymes restrict marginal zone B cells.

scientific article published on 21 January 2015

After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes

scientific article published on 15 December 2006

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro

scientific article

BCL6 is critical for the development of a diverse primary B cell repertoire

scientific article

CD30 defines a subset of activated human T cells that produce IFN-gamma and IL-5 and exhibit enhanced B cell helper activity

scientific article published on 01 October 1994

CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells

scientific article published on 01 September 1993

CD44 is dispensable for B lymphopoiesis

scientific article published on 01 August 2004

Chapter 13. Identifying substrates of mRNA decay factors by a combined RNA interference and DNA microarray approach.

scientific article published in January 2008

Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes.

scientific article

Characterization of solubilized insulin receptors from rat liver microsomes. Existence of two receptor species with different binding properties

scientific article published on 01 January 1986

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

scientific article

Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell survival

scientific article published on 29 August 2013

Cutting edge: signaling and cell surface expression of a mu H chain in the absence of lambda 5: a paradigm revisited.

scientific article published on October 2003

Cycloheximide, a new tool to dissect specific steps in ER-associated degradation of different substrates

scientific article published on 01 June 1999

Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation

scientific article

Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.

scientific article

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

scientific article published on 14 February 2018

Essential control of early B-cell development by Mef2 transcription factors

scientific article published on 10 December 2015

Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

scientific article

Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

scientific article published on February 2007

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

High rates of deletions in the constant region segment of the immunoglobulin mu gene.

scientific article

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing

scientific article

Human INT6/eIF3e is required for nonsense-mediated mRNA decay

scientific article

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro

scientific article published on 05 December 2020

IgA plasma cells in vascular tissue of patients with Kawasaki syndrome.

scientific article

Immunoglobulin mRNA stability varies during B lymphocyte differentiation

scientific article

Immunoglobulin mu heavy chains do not mediate tyrosine phosphorylation of Ig alpha from the ER-cis-Golgi.

scientific article published on September 2003

Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production

scientific article published on 01 February 1998

Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate.

scientific article

Interleukin-12 activates interferon-gamma production by targeted activation of CD30+ T cells

scientific article published on 01 October 1996

Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.

scientific article published on 31 August 2017

LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase

scientific article

Large cytoplasmic inclusion body kappa-chain has unusual intrachain disulfide bonding.

scientific article published in June 1993

Lipid rafts associate with intracellular B cell receptors and exhibit a B cell stage-specific protein composition.

scientific article

Lytic Epstein-Barr virus infection in epithelial cells but not in B-lymphocytes is dependent on Blimp1.

scientific article published on 25 January 2012

Measurements of mutation rates in B lymphocytes.

scientific article published on April 1987

Monoclonal antibodies to discriminate the EF hand containing calcium binding adaptor proteins EFhd1 and EFhd2.

scientific article published on August 2013

New surprises from the deep--the family of small regulatory RNAs increases.

scientific article

Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression

scientific article published in July 2003

Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

scientific article

Prolonged Ex vivo expansion and differentiation of naïve murine CD43(-) B splenocytes.

scientific article

Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein.

scientific article published on 14 February 2011

Regulation of Energy Metabolism during Early B Lymphocyte Development

scientific article published on 27 July 2018

Selection of Ig μ Heavy Chains by Complementarity-Determining Region 3 Length and Amino Acid Composition ⬇️

scientific article published on November 1, 2003

Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA.

scientific article published on October 1995

Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance

scientific article published on 01 November 2006

Surrogate light chain-dependent selection of Ig heavy chain V regions.

scientific article published on December 1995

Swiprosin 1 – regulator of proximal BCR signaling.

scientific article published on 26 February 2009

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts

scientific article

Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity

scientific article published on 16 September 2014

T-cell receptor diversity prevents T-cell lymphoma development

scientific article published on 30 May 2012

TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells

scientific article published on 10 September 2020

TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells

scientific article

Tfg (Trk fused gene) is a Carma-1/IKKγ interacting protein involved in CD40-induced canonical NF-κB signaling

article

The Early Marginal Zone B Cell-Initiated T-Independent Type 2 Response Resists the Proteasome Inhibitor Bortezomib ⬇️

scientific article published on October 4, 2010

The pre-B cell receptor: turning autoreactivity into self-defense

scientific article published on 30 March 2010

The role of the miR-148/-152 family in physiology and disease.

scientific article

Three-dimensional modeling of a pre-B-cell receptor

scientific article published in March 2004

Towards the generation of B-cell receptor retrogenic mice

scientific article

Transcription factor YY1 can control AID-mediated mutagenesis in mice

scientific article

Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor.

scientific article published on 2 August 2007

Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose

scientific article

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.

scientific article published in November 2006

[MicroRNAs in B-cells and T-cells as regulators of inflammation]

scientific article published on 01 August 2011

miR-148a controls metabolic programming and survival of mature CD19-negative plasma cells in mice

scientific article published on 18 December 2020

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.

scientific article published on 22 January 2015

miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2.

scientific article

miR-9 enhances IL-2 production in activated human CD4(+) T cells by repressing Blimp-1.

scientific article published in August 2012

miRNA meets plasma cells "How tiny RNAs control antibody responses".

scientific article

List of works by Hans-Martin Jäck

A B220(-), CD19(-) population of B cells in the peripheral blood of quasimonoclonal mice.

A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.

A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.

A facile method to increase titers of miRNA-encoding retroviruses by inhibition of the RNaseIII enzyme Drosha.

A gene regulation system with four distinct expression levels

A new staining protocol for detection of murine antibody-secreting plasma cell subsets by flow cytometry

A web platform for the network analysis of highthroughput data in melanoma and its use to investigate mechanisms of resistance to anti-PD1 immunotherapy.

APOBEC3 enzymes restrict marginal zone B cells.

After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro

BCL6 is critical for the development of a diverse primary B cell repertoire

CD30 defines a subset of activated human T cells that produce IFN-gamma and IL-5 and exhibit enhanced B cell helper activity

CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells

CD44 is dispensable for B lymphopoiesis

Chapter 13. Identifying substrates of mRNA decay factors by a combined RNA interference and DNA microarray approach.

Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes.

Characterization of solubilized insulin receptors from rat liver microsomes. Existence of two receptor species with different binding properties

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell survival

Cutting edge: signaling and cell surface expression of a mu H chain in the absence of lambda 5: a paradigm revisited.

Cycloheximide, a new tool to dissect specific steps in ER-associated degradation of different substrates

Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation

Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

Essential control of early B-cell development by Mef2 transcription factors

Evidence of abortive plasma cell differentiation in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.

Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

Guidelines for the use of flow cytometry and cell sorting in immunological studies

High rates of deletions in the constant region segment of the immunoglobulin mu gene.

HnRNP L and L-like cooperate in multiple-exon regulation of CD45 alternative splicing

Human INT6/eIF3e is required for nonsense-mediated mRNA decay

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro

IgA plasma cells in vascular tissue of patients with Kawasaki syndrome.

Immunoglobulin mRNA stability varies during B lymphocyte differentiation

Immunoglobulin mu heavy chains do not mediate tyrosine phosphorylation of Ig alpha from the ER-cis-Golgi.

Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production

Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate.

Interleukin-12 activates interferon-gamma production by targeted activation of CD30+ T cells

Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.

LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase

Large cytoplasmic inclusion body kappa-chain has unusual intrachain disulfide bonding.

Lipid rafts associate with intracellular B cell receptors and exhibit a B cell stage-specific protein composition.

Lytic Epstein-Barr virus infection in epithelial cells but not in B-lymphocytes is dependent on Blimp1.

Measurements of mutation rates in B lymphocytes.

Monoclonal antibodies to discriminate the EF hand containing calcium binding adaptor proteins EFhd1 and EFhd2.

New surprises from the deep--the family of small regulatory RNAs increases.

Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression

Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

Prolonged Ex vivo expansion and differentiation of naïve murine CD43(-) B splenocytes.

Proteome profiling suggests a pro-inflammatory role for plasma cells through release of high-mobility group box 1 protein.

Regulation of Energy Metabolism during Early B Lymphocyte Development

Selection of Ig μ Heavy Chains by Complementarity-Determining Region 3 Length and Amino Acid Composition ⬇️

Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA.

Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance

Surrogate light chain-dependent selection of Ig heavy chain V regions.

Swiprosin 1 – regulator of proximal BCR signaling.

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts

Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunity

T-cell receptor diversity prevents T-cell lymphoma development

TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells

TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells

Tfg (Trk fused gene) is a Carma-1/IKKγ interacting protein involved in CD40-induced canonical NF-κB signaling

The Early Marginal Zone B Cell-Initiated T-Independent Type 2 Response Resists the Proteasome Inhibitor Bortezomib ⬇️

The pre-B cell receptor: turning autoreactivity into self-defense

The role of the miR-148/-152 family in physiology and disease.

Three-dimensional modeling of a pre-B-cell receptor

Towards the generation of B-cell receptor retrogenic mice

Transcription factor YY1 can control AID-mediated mutagenesis in mice

Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor.

Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.

[MicroRNAs in B-cells and T-cells as regulators of inflammation]

miR-148a controls metabolic programming and survival of mature CD19-negative plasma cells in mice

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.

miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2.

miR-9 enhances IL-2 production in activated human CD4(+) T cells by repressing Blimp-1.

miRNA meets plasma cells "How tiny RNAs control antibody responses".