List of works - Pierfausto Seneci

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

scientific article

A combinatorial approach to [1,5]benzothiazepine derivates as potential antibacterial agents.

scientific article

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

scholarly article

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

scientific article published on 27 November 2013

Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

scientific article

DFG-in and DFG-out homology models of TrkB kinase receptor: induced-fit and ensemble docking.

scientific article

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

scientific article

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

scientific article

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

scientific article published on 22 August 2016

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

scientific article published in 2012

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

scientific article

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

scientific article published on 8 July 2010

Peptide aldehydes as inhibitors of HIV protease.

scientific article published on March 1993

Polymer-supported silyl cyanide and silyl azide: useful reagents for solid-phase applications

scientific article published on 01 January 2000

Proapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis.

scientific article

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

scientific article

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

scientific article

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

scientific article

Regiospecific synthesis of mono-N-substituted indolopyrrolocarbazoles

scientific article published on 01 October 2005

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

scientific article published on 31 July 2020

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

scientific article published on 25 March 2014

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

scientific article

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

scientific article

Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes

scientific article published on 17 February 2016

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

scientific article published in September 2001

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

scientific article

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

scientific article

Studies on the novel anti-staphyloccal compound nematophin

scientific article published on 01 August 2000

Synthesis and biological activity of O56-substituted carboxyesters and carboxamides of teicoplanin aglycone

scientific article published on October 1, 1992

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

scientific article published on 16 April 2014

Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus

scientific article published on 26 January 2012

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

scientific article

List of works by Pierfausto Seneci

A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein.

A combinatorial approach to [1,5]benzothiazepine derivates as potential antibacterial agents.

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

DFG-in and DFG-out homology models of TrkB kinase receptor: induced-fit and ensemble docking.

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

Peptide aldehydes as inhibitors of HIV protease.

Polymer-supported silyl cyanide and silyl azide: useful reagents for solid-phase applications

Proapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

Regiospecific synthesis of mono-N-substituted indolopyrrolocarbazoles

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology.

Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity

Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

Studies on the novel anti-staphyloccal compound nematophin

Synthesis and biological activity of O56-substituted carboxyesters and carboxamides of teicoplanin aglycone

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting α(v)β(3)/α(v)β(5) integrins and IAP proteins.

Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles