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List of works by Chin B. Eap

A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: prediction of infant drug exposure through breast milk

scientific article published on 12 March 2020

ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

article

ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.

scientific article published in August 2009

Adherence to Antidepressant Treatment: What the Doctor Thinks and What the Patient Says

Adverse Drug Reactions Following Nonresponse in a Depressed Patient with CYP2D6 Deficiency and Low CYP 3A4/5 Activity

Amisulpride: Real-World Evidence of Dose Adaptation and Effect on Prolactin Concentrations and Body Weight Gain by Pharmacokinetic/Pharmacodynamic Analyses

scientific article published on 01 March 2020

Analysis of the enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography

article

Analytical methods for the quantitative determination of selective serotonin reuptake inhibitors for therapeutic drug monitoring purposes in patients.

scientific article

Aripiprazole and suicidality

scientific article published in March 2006

Artifacts in the analysis of thioridazine and other neuroleptics

scientific article published on 01 June 1993

Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

scientific article published on 24 July 2017

Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression

scientific article

Association of CYP3A5 genotypes with blood pressure and renal function in African families

scientific article

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments

scientific article published on 14 August 2015

Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment

scientific article

Association of genetic risk scores with body mass index in Swiss psychiatric cohorts

scientific article

Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy

scientific article

Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs

scientific article published on 7 July 2017

Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions

scientific article published on 8 December 2014

Automated LC-MS method for the fast stereoselective determination of methadone in plasma.

scientific article

Binding of amitriptyline to alpha 1-acid glycoprotein and its variants.

scientific article published in November 1988

Blood pressure in relation to coffee and caffeine consumption

scientific article published on September 2014

Brain dopamine response in human opioid addiction.

scientific article

Buprenorphine and norbuprenorphine quantification in human plasma by simple protein precipitation and ultra-high performance liquid chromatography tandem mass spectrometry

scientific article published on 28 December 2012

CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response

scientific article published in August 2008

CYP3A activity measured by the midazolam test is not related to 3435 C >T polymorphism in the multiple drug resistance transporter gene

scientific article published in April 2004

CYP3A5 and ABCB1 genes and hypertension

scientific article published on March 2009

CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt

scientific article

CYP3A7, CYP3A5, CYP3A4, and ABCB1 Genetic Polymorphisms, Cyclosporine Concentration, and Dose Requirement in Transplant Recipients

article

Caffeine Consumption in Switzerland: Results from the First National Nutrition Survey MenuCH

scientific article published on 20 December 2019

Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension

Can valproic acid be an inducer of clozapine metabolism?

scientific article

Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: a transnational study

scientific article

Carbamazepine augmentation in depressive patients non-responding to citalopram: a pharmacokinetic and clinical pilot study

scientific article

Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS.

scientific article published in August 2004

Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response: a pilot study

scientific article published on 30 September 2008

Clinically Significant Drug-Drug Interactions with Agents for Attention-Deficit/Hyperactivity Disorder

scientific article published on 01 December 2019

Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition

scientific article published in 2023

Combination therapy with venlafaxine and carbamazepine in depressive patients not responding to venlafaxine: pharmacokinetic and clinical aspects

scientific article published in December 2004

Comparative Long-Term Effect of Three Anti-P2Y12 Drugs after Percutaneous Angioplasty: An Observational Study Based on Electronic Drug Adherence Monitoring.

scientific article

Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers.

scientific article published in June 2001

Concentrações plasmáticas de paroxetina em pacientes adultos e idosos com depressão

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.

scientific article

Correspondence

scientific article published on 01 March 1998

Cytochrome P -450 activities in human and rat brain microsomes

article

Cytochrome P450 2D6 Genotype and Methadone Steady-State Concentrations

article

Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study

scientific article published on 8 December 2010

Death following acute poisoning by moclobemide.

scientific article published in February 2004

Determination and distribution of clotiapine (Entumine) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases

scientific article

Determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma by gas chromatography–mass spectrometry

scientific article published on 01 January 1998

Determination of human plasma levels of levo-alpha-acetylmethadol and its metabolites by gas chromatography-mass spectrometry.

scientific article published in June 2004

Determination of plasma levels of citalopram and its demethylated and deaminated metabolites by gas chromatography and gas chromatography—mass spectrometry

scientific article published on 01 July 1993

Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients

scientific article published on 01 January 1994

Determination of the enantiomers of thioridazine, thioridazine 2-sulfone, and of the isomeric pairs of thioridazine 2-sulfoxide and thioridazine 5-sulfoxide in human plasma

scientific article published on 01 July 1995

Determination of trimipramine and its demethylated and hydroxylated metabolites in plasma by gas chromatography—mass spectrometry

scientific article published on 01 January 1994

Determination of unbound antiretroviral drug concentrations by a modified ultrafiltration method reveals high variability in the free fraction.

scientific article published in August 2008

Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction

scientific article published on 3 October 2015

Disposition of venlafaxine enantiomers in rats with hepatic encephalopathy after chronic drug treatment

scientific article published in May 2002

Efavirenz decreases methadone blood concentrations

article

Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients

scientific article published in July 2005

Effect of long-term adherence to clopidogrel on the VASP-PRI after elective coronary stent implantation: a randomized controlled study.

scientific article published on 22 July 2016

Effects of Carbamazepine Coadministration on Plasma Concentrations of the Enantiomers of Mianserin and of its Metabolites

scientific article published on 01 April 1999

Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram

scientific article

Epileptiform Seizure After Sertraline Treatment in an Adolescent Experiencing Obsessive-Compulsive Disorder and Presenting a Rare Pharmacogenetic Status

scientific article published on 01 December 2006

Escitalopram population pharmacokinetics in people living with human immunodeficiency virus and in the psychiatric population: Drug-drug interactions and probability of target attainment

scientific article published on 07 July 2019

Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients

scientific article published in 2023

Fast quantification of ten psychotropic drugs and metabolites in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring

scientific article published on 9 January 2013

Fluoxetine Addition to Methadone in Addicts: Pharmacokinetic Aspects

article

Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.

scientific article

Fluvoxamine and perphenazine for psychosis in Alzheimer's disease: pharmacokinetic considerations.

scientific article published in November 2001

Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women

scientific article

Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort

scientific article

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior

scientific article published on 3 October 2016

High Interindividual Variability of Methadone Enantiomer Blood Levels to Dose Ratios

article

High dose of depot risperidone in a nonresponder schizophrenic patient

scientific article published in December 2004

High-dose venlafaxine treatment in a depressed patient with a genetic CYP2D6 deficiency

scientific article published on 01 January 2004

Identification of a novel splice-site mutation in the CYP1A2 gene

scientific article published in September 2003

Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments

scientific article

Impact of Smoking, Smoking Cessation, and Genetic Polymorphisms on CYP1A2 Activity and Inducibility

scientific article published on 18 May 2011

Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment

scientific article published on November 2015

In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites

scientific article published on 9 August 2007

In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function

scientific article published in April 2009

Increase of Oral Methadone Dose in Methadone Injecting Patients

scientific article published on 01 January 2003

Increased (R)-Methadone Plasma Concentrations by Quetiapine in Cytochrome P450s and ABCB1 Genotyped Patients

scientific article published on 01 June 2007

Increased clozapine plasma concentrations and side effects induced by smoking cessation in 2 CYP1A2 genotyped patients

scientific article published in August 2005

Increased trimipramine plasma levels during fluvoxamine comedication

scientific article published on 01 March 1994

Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients.

scientific article

Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population

scientific article published in October 2013

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression

scientific article published on 13 October 2015

Influence of body weight and UGT2B7 polymorphism on varenicline exposure in a cohort of smokers from the general population

scientific article published on 13 March 2019

Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking

scientific article published on February 2012

Influence of polygenic risk scores on lipid levels and dyslipidemia in a psychiatric population receiving weight gain-inducing psychotropic drugs

scientific article published on 21 September 2017

Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers

scientific article published in July 1998

Isoelectric focusing of alpha-1 acid glycoprotein (orosomucoid) in immobilized pH-gradients with 8M urea: Detection of its desialylated variants using an alkaline phosphatase-linked secondary antibody system

scientific article published on 01 October 1988

Lack of association between genetic polymorphisms of ARRB2 and alcohol dependence in a Caucasian population.

scientific article published on 23 September 2010

Long-term citalopram administration reduces responsiveness of HPA axis in patients with major depression: relationship with S-citalopram concentrations in plasma and cerebrospinal fluid (CSF) and clinical response

scientific article published on 29 September 2005

Marked Increase of Venlafaxine Enantiomer Concentrations as a Consequence of Metabolic Interactions: A Case Report

scientific article published on 01 May 2000

Monitoring caffeine intake in children with a questionnaire and urine collection: a cross-sectional study in a convenience sample in Switzerland

scientific article published on 03 February 2020

Monographs on drugs which are frequently analyzed in therapeutic drug monitoring / Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden

article published in 2010

Monographs on drugs which are frequently analyzed in therapeutic drug monitoring / Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden

Monographs on drugs which are frequently analyzed in therapeutic drug monitoring / Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden

Monographs on drugs which are frequently analyzed in therapeutic drug monitoring/Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden

Multicenter study on the clinical effectiveness, pharmacokinetics, and pharmacogenetics of mirtazapine in depression

scientific article published in October 2012

Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram

scientific article published on 23 March 2005

No Influence of ABCB1 Haplotypes on Methadone Dosage Requirement

scientific article published on 01 May 2008

Nonresponse to clozapine and ultrarapid CYP1A2 activity: clinical data and analysis of CYP1A2 gene

scientific article

Oral and intravenous methadone use: some clinical and pharmacokinetic aspects

scientific article published on 01 June 1999

Orosomucoid (alpha-1 acid glycoprotein) phenotyping by use of immobilized pH gradients with 8M urea and immunoblotting

scientific article published on 01 October 1988

Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation

scientific article

Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers

scientific article published in April 2002

Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease

scientific article

Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects.

scientific article published on June 2013

Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers

scientific article published on 01 May 2013

Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements

scientific article published in December 2007

Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals

scientific article published on 18 February 2009

Pharmacogenomics in psychiatry: from therapeutic drug monitoring to genomic medicine

scientific article

Pharmacokinetic Interaction Between Valproic Acid, Meropenem, and Risperidone

scientific article published on 10 December 2015

Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test.

scientific article published in June 2001

Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment

article

Plasma levels and cerebrospinal fluid penetration of venlafaxine in a patient with a nonfatal overdose during a suicide attempt

scientific article

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

scientific article

Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients

scientific article

Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance

scientific article

Population pharmacokinetic study of memantine: effects of clinical and genetic factors

scientific article

Prediction of early weight gain during psychotropic treatment using a combinatorial model with clinical and genetic markers

scientific article published on 12 October 2016

Prediction of free imatinib concentrations based on total plasma concentrations in patients with gastrointestinal stromal tumours

scientific article published on April 2013

Prevalence of methadone injection in three Swiss cities.

scientific article published on June 2005

Prevalence of substance use in a Swiss psychiatric hospital: interview reports and urine screening

scientific article published on 30 August 2005

Psychotropic drug-induced weight gain and other metabolic complications in a Swiss psychiatric population

scientific article published on 7 February 2012

Quantification of 4 antidepressants and a metabolite by LC–MS for therapeutic drug monitoring

scientific article published on 04 April 2011

Quantification of nicotine, cotinine, trans-3′-hydroxycotinine and varenicline in human plasma by a sensitive and specific UPLC–tandem mass-spectrometry procedure for a clinical study on smoking cessation

scientific article published on 01 October 2011

Quantification of typical antipsychotics in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring

scientific article

Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population.

scientific article

Relationship of CYP2D6, CYP3A, POR, and ABCB1 genotypes with galantamine plasma concentrations

scientific article

Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

article

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

scientific article published in January 2002

Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence

scientific article published on 02 January 2015

Risperidone-induced symptomatic hyperprolactinaemia in adolescents

scientific article published in April 2006

Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans

scientific article

Routine Therapeutic Drug Monitoring in Patients Treated with 10-360 mg/day Citalopram ⬇️

scientific article published on October 1, 2003

Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein

scientific article published on 01 February 1988

Serotonin toxicity after addition of mirtazapine to escitalopram.

scientific article

Severe manic episode associated with tramadol in a patient with recurrent depressive disorder

scientific article published in April 2015

Simultaneous Determination of Antidementia Drugs in Human Plasma for Therapeutic Drug Monitoring

Simultaneous determination of antidementia drugs in human plasma: Procedure transfer from HPLC–MS to UPLC–MS/MS

scientific article published on 18 February 2012

Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry

scientific article published on 01 July 1996

Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry

scientific article published on 27 April 2017

Simultaneous quantification of selective serotonin reuptake inhibitors and metabolites in human plasma by liquid chromatography–electrospray mass spectrometry for therapeutic drug monitoring

scientific article published on 08 January 2012

Steady State Concentrations of the Enantiomers of Mianserin and Desmethylmianserin in Poor and in Homozygous and Heterozygous Extensive Metabolizers of Debrisoquine

scientific article published on 01 February 1998

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

scientific article published on 28 February 2007

Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry

scientific article published on 20 August 2016

Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients: relationship with 5-HIAA in CSF and clinical response

scientific article published in June 2004

Substance Use in Adolescent Psychiatric Outpatients: Self-Report, Health Care Providers' Clinical Impressions, and Urine Screening

article

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test

scientific article published in November 2009

The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.

scientific article

The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution

scientific article published on August 2010

Therapeutic drug monitoring and pharmacogenetic tests as tools in pharmacovigilance

scientific article published on January 2006

Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.

scientific article published on 15 August 2009

Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.

scientific article published in April 2004

Time course of response to paroxetine: influence of plasma level

scientific article

Two-step chromatographic purification of human plasma alpha(1)-acid glycoprotein: its application to the purification of rare phenotype samples of the protein and their study by chromatography on immobilized metal chelate affinity adsorbent

scientific article published in March 1996

Use of High Doses of Quetiapine in Bipolar Disorder Episodes are not Linked to High Activity of Cytochrome P4503A4 and/or Cytochrome P4502D6

scientific article published on 01 September 2013

Use of transgenic mice for the characterization of human alpha 1-acid glycoprotein (orosomucoid) variants

scientific article published on 01 December 1989

Usefulness of methadone plasma concentration measurement in patients receiving nevirapine or efavirenz

scientific article

Using saccadic eye movements as objective measures of tolerance in methadone dependent individuals during the hydromorphone challenge test ⬇️

scientific article published on March 1, 2003

Validation and long-term evaluation of a modified on-line chiral analytical method for therapeutic drug monitoring of (R,S)-methadone in clinical samples

scientific article published on 17 March 2009

Variability of response to methadone: genome-wide DNA methylation analysis in two independent cohorts

scientific article published on 21 January 2016

Variations in relative concentrations of variants of human α1-acid glycoprotein after acute-phase conditions

scientific article published on 01 December 1991

Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients

scientific article published on 19 January 2005

Very High Cytochrome P4501A2 Activity and Nonresponse to Clozapine

article

Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer

scientific article published in August 2002

Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations

scientific article

β-Arrestin2 influences the response to methadone in opioid-dependent patients.

scientific article published in June 2010

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