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List of works by Angeles Canales

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

scientific article published on 08 October 2014

A rigid lanthanide binding tag for NMR structural analysis of carbohydrates

scientific article published on 23 May 2011

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

scientific article

Antimicrobial peptides and their superior fluorinated analogues: structure-activity relationships as revealed by NMR spectroscopy and MD calculations.

scientific article

Avenues to Characterize the Interactions of Extended N-Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case

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Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods.

scientific article published on 29 July 2006

Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts.

scientific article published on 4 November 2013

Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins.

scientific article

Cell wall polysaccharides isolated from the fungus Neotestudina rosatii, one of the etiologic agents of mycetoma in man.

scientific article

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

scientific article published on 5 January 2018

Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.

scientific article

Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.

scientific article

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440

scientific article

Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

scientific article published on 01 September 2006

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

scientific article

Dextrans produced by lactic acid bacteria exhibit antiviral and immunomodulatory activity against salmonid viruses.

scientific article

Enhanced signal dispersion in saturation transfer difference experiments by conversion to a 1D-STD-homodecoupled spectrum

scientific article published on 20 September 2006

Exploring NMR methods as a tool to select suitable fluorescent nucleotide analogues.

scientific article published in August 2013

Glycosylated Cell-Penetrating Peptides (GCPPs)

scientific article published on 12 April 2019

Heparin Modulates the Mitogenic Activity of Fibroblast Growth Factor by Inducing Dimerization of its Receptor. A 3D View by Using NMR

scientific article published on August 12, 2013

Hevein domains: an attractive model to study carbohydrate-protein interactions at atomic resolution

scientific article

Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.

scientific article published on 6 December 2017

Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

scientific article published on 11 July 2014

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

scientific article published on 26 June 2019

Insights into the C-terminal Peptide Binding Specificity of the PDZ Domain of Neuronal Nitric-oxide Synthase: CHARACTERIZATION OF THE INTERACTION WITH THE TIGHT JUNCTION PROTEIN CLAUDIN-3.

scientific article

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach

scientific article published on May 13, 2011

Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods

scientific article

Isolation and structural determination of a unique polysaccharide containing mannofuranose from the cell wall of the fungus Acrospermum compressum.

scientific article

Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions.

scientific article published on 27 May 2014

Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods

scientific article

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes

scientific article published on December 20, 2011

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

scientific article published on 25 February 2014

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

scientific article published on August 16, 2010

Molecular dynamics study of nanoconfined TIP4P/2005 water: how confinement and temperature affect diffusion and viscosity

scientific article published on 13 June 2019

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

scientific article

NMR experiments for the measurement of proton-proton and carbon-carbon residual dipolar couplings in uniformly labelled oligosaccharides

scientific article published in August 2003

NMR studies on the conformation of oligomannosides and their interaction with banana lectin

scientific article published on 11 May 2007

New inhibitors of angiogenesis with antitumor activity in vivo

scientific article published on 4 May 2015

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

scientific article

Novel pH-Stable Glycoside Hydrolase Family 3 β-Xylosidase from Talaromyces amestolkiae: an Enzyme Displaying Regioselective Transxylosylation.

scientific article published on 6 July 2015

Recent advances on the application of NMR methods to study the conformation and recognition properties of carbohydrates

article

Review: use of residual dipolar couplings to determine the structure of carbohydrates

scientific article published on December 1, 2012

Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.

scientific article published on 21 September 2006

Solution conformation of carbohydrates: a view by using NMR assisted by modeling

scientific article published on 01 January 2015

Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin

scientific article published on 12 August 2016

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

scientific article

Synthesis and NMR experiments of (4,5,6-13C)-deoxymannojirimycin. A new entry to 13C-labeled glycosidase inhibitors

scientific article published on 29 April 2007

Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications

scientific article published on 17 March 2012

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

scientific article published on 3 August 2016

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

scientific article

Temperature dependence of ligand–protein complex formation as reflected by saturation transfer difference NMR experiments

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Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

scientific article

Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

scientific article published on 27 February 2012

Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations

scientific article

Unraveling the interaction between the LPS O-antigen of Burkholderia anthina and the 5D8 monoclonal antibody by using a multidisciplinary chemical approach, with synthesis, NMR, and molecular modeling methods

scientific article published on 22 July 2013

Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida

scientific article published on November 16, 2010

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules

scientific article published on June 22, 2012