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List of works by Carmen Gil

5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

scientific article published on 28 January 2012

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

scientific article published on 3 February 2012

A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice.

scientific article published on 19 December 2016

Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles.

scientific article

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.

scientific article published on 20 February 2018

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

scientific article published in August 2000

Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity

scientific article published in May 2003

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

scientific article published on 26 December 2019

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease

scientific article published on 30 August 2017

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

article

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

scientific article published on 21 December 2007

CODES/Neural Network Model: a Useful Tool for in Silico Prediction of Oral Absorption and Blood-Brain Barrier Permeability of Structurally Diverse Drugs

article

Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors

scientific article

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis.

scientific article published on October 2013

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

scientific article published on 17 January 2014

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

scientific article published on 24 September 2018

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors

scientific article

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

article

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

scientific article published on 01 December 2020

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

scientific article

Discovery of Amoebicidal Compounds by Combining Computational and Experimental Approaches

scientific article published on 23 November 2020

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

scientific article published on 01 July 2019

Drugs in clinical development for the treatment of amyotrophic lateral sclerosis

scientific article published on 6 March 2017

Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

scientific article

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

scientific article published on 16 March 2012

Efficient solid-phase synthesis of highly functionalized 1,4-benzodiazepin-5-one derivatives and related compounds by intramolecular aza-Wittig reactions

scientific article published in April 2005

Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders

scientific article published on 26 April 2016

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

scientific article

Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

scientific article

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

scientific article published on 12 August 2015

Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment ⬇️

scientific article published on June 30, 2011

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

scientific article

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

scientific article

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

scientific article

Imidazole Derivatives as Promising Agents for the Treatment of Chagas Disease

scientific article published on 27 March 2019

Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

scientific article published on 10 May 2013

Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?

scientific article published on 21 March 2017

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

scientific article

Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents

scientific article published on 29 June 2017

Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.

scientific article published on 16 August 2017

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

scientific article published on 5 October 2012

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

scientific article

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

scientific article published on 8 October 2014

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

scientific article

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

scientific article published on 25 March 2016

New insights into the role of endosomal proteins for African swine fever virus infection

scientific article published on 26 January 2022

Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives

scientific article published on 14 September 2007

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

scientific article

On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds

Organic azides: an exploding diversity of a unique class of compounds

scientific article

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

scientific article published on 31 January 2011

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

scientific article

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

scientific article published on 09 May 2017

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

scientific article published on 29 April 2015

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

scientific article (publication date: 24 February 2011)

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

scientific article published on 9 April 2013

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

scientific article published on 19 August 2016

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.

scientific article published on 3 March 2017

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

scientific article

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

scientific article

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

scientific article published on 14 February 2019

Recent strategies in the development of new human cytomegalovirus inhibitors.

scientific article

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

scientific article published on 14 January 2019

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

scientific article published on 13 October 2014

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

scientific article (publication date: 2016)

Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa.

scientific article published in December 2017

Solid-phase synthesis of biologically active benzoannelated nitrogen heterocycles: an update.

scientific article published on March 2009

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

scientific article published on 26 May 2017

Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells

article

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

scientific article

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.

scientific article published on 4 September 2017

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

scientific article published on 30 April 2016

The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis

scientific article published on 21 December 2016

The Synthesis of 3-Substituted 6-Aryl-3H-benzo[a][1,2,3]triazinones Using Polymer-Bound Triazenes

scientific article published on 01 January 2004

The recent impact of solid-phase synthesis on medicinally relevant benzoannelated nitrogen heterocycles.

scientific article

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.

scientific article published on 22 August 2009

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

scientific article published on 01 December 2020

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

scientific article published on 22 October 2013

cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases

scientific article published on 04 October 2014

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.

scientific article published on 25 April 2013

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