List of works by Marco Gobbi

5-HT3 serotonin hetero-receptors inhibit [3H]acethylcholine release in rat cortical synaptosomes.

scientific article published on April 1997

6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.

scientific article

A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors.

scientific article published on 11 March 2016

A Surface Plasmon Resonance-based assay to measure serum concentrations of therapeutic antibodies and anti-drug antibodies

scientific article published in Scientific Reports

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

scientific article published on 15 March 2016

A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)₁₋₄₀ and Aβ₁₋₄₂ from the corresponding depsipeptides

scientific article published on 24 December 2010

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10

scientific article

A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma

scientific article

A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

scientific article published on 19 November 2021

A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake

scientific article

A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

scientific article published on March 2009

A validated, sensitive HPLC-MS/MS method for quantification of cis-para-methyl-4-methylaminorex (cis-4,4'-DMAR) in rat and human plasma: application to pharmacokinetic studies in rats.

scientific article published on 10 August 2016

Acute noise stress in rats increases the levels of diazepam binding inhibitor (DBI) in hippocampus and adrenal gland

scientific article published on 01 January 1991

Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine.

scientific article

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

scientific article

Allosteric inhibition as a model to explain flatter displacement curves in binding experiments: application to "heterogeneous" serotonin receptors

scientific article published in January 1986

Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis

scientific article (publication date: July 2011)

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

scientific article published on 28 January 2013

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

scientific article published on 07 August 2017

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms

scientific article published on 01 March 1993

Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain

scientific article published in May 1990

Antiepileptic effects of botulinum neurotoxin E.

scientific article

Applications of surface plasmon resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes.

scientific article published on 27 November 2012

Appraisal of the role of angiotensin II and aldosterone in ventricular myocyte apoptosis in adult normotensive rat.

scientific article

Autoradiographic localization of [(3)H]paroxetine specific binding in the rat brain

scientific article published in January 1990

Autoradiographic reevaluation of the binding properties of 125I-[Leu31,Pro34]peptide YY and 125I-peptide YY3-36 to neuropeptide Y receptor subtypes in rat forebrain

scientific article published in April 1999

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

scientific article published on 4 June 2013

Biochemical characterization of a new highly cardioselective beta-adrenoceptor antagonist

scientific article published on 01 April 1988

Brain Disposition of cis-para-Methyl-4-Methylaminorex (cis-4,4'-DMAR) and Its Potential Metabolites after Acute and Chronic Treatment in Rats: Correlation with Central Behavioral Effects.

scientific article published on 12 April 2017

Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.

scientific article published on 19 August 2015

Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine.

scientific article

Carrier-mediated Serotonin Release Induced by d-Fenfluramine: Studies with Human Neuroblastoma Cells Transfected with a Rat Serotonin Transporter ⬇️

scientific article published on June 1, 1997

Characterization of high affinity and stereospecific [ (3)H ]d- fenfluramine binding to rat brain

scientific article published in January 1988

Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.

scientific article published on 16 February 2016

Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide

scientific article published on 04 December 2010

Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.

scientific article published on April 2010

Different components of 3H-imipramine binding in rat brain membranes: relation to serotonin uptake sites

scientific article published in January 1988

Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain

scientific article

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

scientific article published on 12 June 2018

Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial.

scientific article published on 8 January 2014

Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest

scientific article

Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: an autoradiographic study

scientific article

Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats ⬇️

scientific article published on July 1, 1997

Effects of denzimol on benzodiazepine receptors in the CNS: relationship between the enhancement of diazepam activity and benzodiazepine binding sites induced by denzimol in the rat.

scientific article published in October 1984

Effects of fluoxetine on basal and K(+)-induced tritium release from synaptosomes preloaded with [3H]serotonin.

scientific article published on January 1995

Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain

scientific article published in November 1996

Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.

scientific article

Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.

scientific article

Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes

scientific article published in July 1993

Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption

scientific article

Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity

scientific article

Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus

scientific article

Further evidence of Ca(2+)-dependent, exocytotic-like serotonin release induced by D-fenfluramine

scientific article published in May 1997

Gene therapy in epilepsy: the focus on NPY.

scientific article published on 28 December 2006

Good gene, bad gene: new APP variant may be both

scientific article published on 19 June 2012

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

scientific article published on 01 September 1999

Immunopurification of pathological prion protein aggregates

scientific article

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat

scientific article published on 01 May 1996

In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool

scientific article published in September 1998

In vivo and in vitro interaction of flunarizine with D-fenfluramine serotonergic effects

scientific article published on 01 January 1996

Involvement of P-type Ca2+ channels in the K(+)- and d-fenfluramine-induced [3H]5-HT release from rat hippocampal synaptosomes

scientific article

Lipid-based nanoparticles with high binding affinity for amyloid-beta1-42 peptide.

scientific article published in September 2010

Localization of GABAA and GABAB receptor subtypes on serotonergic neurons

scientific article published in April 1986

Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus

scientific article

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

scientific article published in August 2011

Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

scientific article published on 8 April 2016

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit

scientific journal article

N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.

scientific article published on 4 February 2008

Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats.

scientific article published in February 2005

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

scientific article

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reupta

scientific article

New insights into the molecular mechanisms underlying sensitivity/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome.

scientific article

New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide

scientific article

Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds

scientific article

Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity.

scientific article

Overexpression of S100beta in transgenic mice does not protect from serotonergic denervation induced by 5,7-dihydroxytryptamine.

scientific article published on February 2002

PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.

scientific article published on 19 June 2012

Pharmacology in the high tech age--new developments, opportunities and limitations

scientific article published on 17 August 2013

Plasma and brain concentrations of doxycycline after single and repeated doses in wild-type and APP23 mice

scientific article published on 05 November 2018

Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin.

scientific article

Profile of in vitro binding affinities of neuroleptics at different rat brain receptors: cluster analysis comparison with pharmacological and clinical profiles

scientific article published on 01 July 1989

QSAR model for blood-brain barrier permeation.

scientific article published on 2 May 2017

QSAR study for a novel series of ortho disubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

scientific article published on 5 June 2006

QSAR study for a novel series of ortho monosubstituted phenoxy analogues of alpha1-adrenoceptor antagonist WB4101.

scientific article

Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest.

scientific article

Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

scientific article published on 18 August 2014

Recombinant C1 inhibitor in brain ischemic injury.

scientific article published in September 2009

Regional distribution of low-affinity GABA receptors coupled to benzodiazepine receptor subtypes in rat brain: an autoradiographic evaluation

scientific article published in September 1990

Regulation of leukocyte recruitment by the long pentraxin PTX3.

scientific article published on 7 March 2010

Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser

scientific article

Releasing activities of d-fenfluramine and fluoxetine on rat hippocampal synaptosomes preloaded with [3H]serotonin

scientific article

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin.

scientific article published on 23 December 2015

Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y.

scientific article published in January 2002

Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury.

scientific article published on 18 October 2013

Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans

scientific article published on 26 June 2012

St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.

scientific article

Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative

scientific article published in December 1984

Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of alpha 1 antagonist WB-4101.

scientific article published in September 2004

Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations

scientific article published on October 2003

Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters

Synthesis of new β- and γ-benzyloxy-S-glutamic acid derivatives and evaluation of their activity as inhibitors of excitatory amino acid transporters

article published in 2009

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

scientific article

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.

scientific article

Tetanus toxin inhibits depolarization-induced [3H]serotonin release from rat brain cortex synaptosomes

scientific article published in March 1993

Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.

scientific article published on 21 February 2013

The Anti-Amyloidogenic Action of Doxycycline: A Molecular Dynamics Study on the Interaction with Aβ42

scientific article published on 19 September 2019

The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers

scientific article published on 06 July 2016

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration

scientific article

The antidepressant mechanism of Hypericum perforatum.

scientific article published on July 2004

The binding affinity of anti-Aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue.

scientific article published on 6 May 2011

The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype

scientific article published in October 1990

The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.

scientific article published on 11 January 2016

Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ(1-42) peptide, synthesized by depsi-peptide technique

scientific article published on 31 October 2010

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.

scientific article

WB4101-related compounds: new, subtype-selective alpha1-adrenoreceptor antagonists (or inverse agonists?).

scientific article published in November 2006

[3H]5-HT binding to 5-HT1nonA-nonB receptors in rat hypothalamus is not representative of 5-HT7 receptors

scientific article published in May 1997

p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.

scientific article

Paulina is supported by:

About Paulina

Help