List of works by Tom Kirkwood

A comparison of subjective and objective measures of physical activity from the Newcastle 85+ study.

scientific article published on 27 May 2015

A mathematical model of ageing in yeast

scientific article published in July 2004

A mathematical model of aging-related and cortisol induced hippocampal dysfunction

scientific article

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks

scientific article published on 23 April 2009

A systematic look at an old problem

scientific article published in Nature

A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation

scientific article

Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study.

scientific article

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

scientific article

Age-related frailty and its association with biological markers of ageing

scientific article published on 13 July 2015

Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach

scientific article published on 2 July 2012

Antihypertensive drug use and risk of cognitive decline in the very old: an observational study - the Newcastle 85+ Study.

scientific article published on 31 July 2015

Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

scientific article published on 16 August 2011

Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study

scientific article published on 11 October 2013

Asymmetry and the origins of ageing.

scientific article

Bladder volume alters cholinergic responses of the isolated whole mouse bladder

scientific article published in February 2006

Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans

scientific article published in June 2006

Can aging be programmed? A critical literature review

scientific article published on 17 August 2016

Changing complexity in aging: a metric not an hypothesis

scientific article published on 01 January 2002

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

scientific article

Commentary: ageing--what's all the noise about? Developments after Gärtner

scientific article published on 20 January 2012

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations

scientific article

Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'.

scientific article

Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study

scientific article published on 13 January 2016

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

scientific article

Dietary Patterns High in Red Meat, Potato, Gravy, and Butter Are Associated with Poor Cognitive Functioning but Not with Rate of Cognitive Decline in Very Old Adults

scientific article

Dietary Patterns and Socioeconomic Status in the Very Old: The Newcastle 85+ Study

scientific article published on 21 October 2015

Differences in the accumulation of mitochondrial defects with age in mice and humans

scientific article published on 12 October 2011

Do reef corals age?

scientific article published on 28 December 2017

Effect of Dietary Patterns on Muscle Strength and Physical Performance in the Very Old: Findings from the Newcastle 85+ Study

scientific article

Evolution of ageing

scientific article

Evolution of asymmetric damage segregation : a modelling approach

scientific article published on January 2012

Evolutionary significance of ageing in the wild

scientific article published on 17 August 2015

Explaining sex differences in lifespan in terms of optimal energy allocation in the baboon

scientific article published on 26 July 2017

Food restriction, evolution and ageing

scientific article

Foresight Mental Capital and Wellbeing Project

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

scientific article published on 30 April 2013

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

scientific article

Genes that shape the course of ageing ⬇️

scientific article published on October 1, 2003

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Gerontology: Healthy old age.

scientific article published in October 2008

Global aging and the brain ⬇️

scientific article published on December 1, 2010

Grip Strength Decline and Its Determinants in the Very Old: Longitudinal Findings from the Newcastle 85+ Study.

scientific article

Grip strength and inflammatory biomarker profiles in very old adults.

scientific article published on 25 May 2017

Grip strength and mortality: a biomarker of ageing?

scientific article published on 13 May 2015

Growing more positive with age: The relationship between reproduction and survival in aging flies

scientific article

Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

scientific article

Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees.

scientific article

Human longevity at the cost of reproductive success

scientific article published in Nature

Improving retention of very old participants in longitudinal research: experiences from the Newcastle 85+ study

scientific article

Initial level and rate of change in grip strength predict all-cause mortality in very old adults

scientific article published on 25 May 2017

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling

scientific article published on 28 May 2015

Intrinsic ageing of gut epithelial stem cells

scientific article

Is there an association between metabolic syndrome and cognitive function in very old adults? The Newcastle 85+ Study

scientific article published on 8 April 2015

Is there evidence for a limit to human lifespan?

scientific article

LINK-AGE: Coordination and consolidation of European biogerontology: en route towards formation of a European college of biogerontology

scientific article published on 30 August 2006

Life-history evolution and the polyphenic regulation of somatic maintenance and survival

scientific article

Longitudinal changes in global and domain specific cognitive function in the very-old: findings from the Newcastle 85+ Study

scientific article published on 22 June 2017

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

scientific article published on 18 March 2015

Macronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study

scientific article

Medical challenges of improving the quality of a longer life

scientific article published on 01 February 2008

Metabolic evolution suggests an explanation for the weakness of antioxidant defences in beta-cells

scientific article published on April 2009

Micronutrient intake and food sources in the very old: analysis of the Newcastle 85+ Study

scientific article

Mitochondria and ageing: winning and losing in the numbers game.

scientific article published in September 2007

Mitochondrial DNA mutations in human colonic crypt stem cells

scientific article published on November 2003

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

scientific article

Mitochondrial mutations and ageing: can mitochondrial deletion mutants accumulate via a size based replication advantage?

scientific article published on 17 September 2013

Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals

scientific article published on 7 June 2013

Modelling cellular senescence as a result of telomere state

scientific article published in June 2003

Modelling telomere shortening and the role of oxidative stress.

scientific article published in February 2002

Modelling the actions of chaperones and their role in ageing.

scientific article published in January 2005

Modelling the disposable soma theory of ageing.

scientific article published in January 2005

New horizons in the compression of functional decline

article published in 2018

New model of health promotion and disease prevention for the 21st century

scientific article published on 8 July 2008

New science for an old problem

scientific article

On the programmed/non-programmed nature of ageing within the life history

scientific article published on September 2011

Pervasive gene expression responses to a fluctuating diet in Drosophila melanogaster

scientific article

Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo

scientific article

Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi-Inflammatory Biomarkers

scientific article published on 14 November 2016

Prevalence and incidence of sarcopenia in the very old: findings from the Newcastle 85+ Study

scientific article

Prevalence of left ventricular dysfunction in a UK community sample of very old people: the Newcastle 85+ study

scientific article

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old

scientific article

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions.

scientific article published on 27 February 2018

Respiratory health and disease in a U.K. population-based cohort of 85 year olds: The Newcastle 85+ Study

scientific article published on 5 January 2016

Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

scientific article

Serum osmolarity and haematocrit do not modify the association between the impedance index (Ht(2)/Z) and total body water in the very old: the Newcastle 85+ study

scientific article published on 17 September 2014

Somatic mutations and ageing in silico

scientific article

Speed-bumps ahead for the genetics of later-life diseases

scientific article published on 06 August 2011

Systems biology of ageing and longevity

scientific article published on January 2011

Tales of old

scientific article published in Nature

Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study.

scientific article

Telomere-driven replicative senescence is a stress response

scientific article published on 01 March 2003

Ten commandments for the future of ageing research in the UK: a vision for action

scientific article published on 3 May 2007

Testing evolutionary theories of menopause

scientific article published in 2007

The National Service Framework--suggestions about priorities for policy development welcome.

scientific article published in September 2002

The breath of life and death

scientific article published in Nature

The connections between general and reproductive senescence and the evolutionary basis of menopause ⬇️

scientific article published on August 1, 2010

The contribution of diseases to the male-female disability-survival paradox in the very old: results from the Newcastle 85+ study

scientific article

The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study.

scientific article published on 25 February 2015

The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support

scientific article published on 29 May 2012

The most pressing problem of our age.

scientific article

The old worm turns more slowly

scientific article published in Nature

The personal and health service impact of falls in 85 year olds: cross-sectional findings from the Newcastle 85+ cohort study

scientific article

The place of genetics in ageing research.

scientific article published on 10 July 2012

The predictive adaptive response: modeling the life-history evolution of the butterfly Bicyclus anynana in seasonal environments

scientific article

The road to rack and ruin: selecting deleterious mitochondrial DNA variants

scientific article

Time of our lives. What controls the length of life?

scientific article

Tools for the SBML Community

scientific article published on 12 January 2006

Towards an e-biology of ageing: integrating theory and data

scientific article published in March 2003

Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions

scientific article published on 05 July 2006

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

scientific article published on 03 February 2014

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance.

scientific article published on April 2016

Untangling functional declines in the locomotion of aging worms

scientific article published on 01 September 2013

Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study.

scientific article

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

scientific article

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

scientific article

What explains variations in the clinical use of mild cognitive impairment (MCI) as a diagnostic category?

scientific article published in April 2008

Why Can't We Live Forever?

scientific article published on 01 September 2010

Why and how are we living longer?

scientific article

Why women live longer. Stress alone does not explain the longevity gap

scientific article published on 01 November 2010

p53 and ageing: too much of a good thing?

scientific article published on 01 July 2002

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