List of works - Menno Hoekstra

Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice

scientific article published in January 2009

Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice

scientific article

Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT.

scientific article

Adrenal-specific scavenger receptor BI deficiency induces glucocorticoid insufficiency and lowers plasma very-low-density and low-density lipoprotein levels in mice

scientific article published on 29 November 2012

Adrenalectomy stimulates the formation of initial atherosclerotic lesions: reversal by adrenal transplantation

scientific article published on 23 December 2011

Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations

scientific article published on 18 October 2011

Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype

scientific article published in 2022

Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

scientific article published on 14 September 2007

Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE

scientific article (publication date: 2011)

Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Increases Hepatic ABCA1 mRNA Expression and HDL-Cholesterol

scientific article published on 28 September 2006

Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.

scientific article published on 25 October 2007

Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels

scientific article published on 15 November 2007

Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol

scientific article

Effects of pyrazole partial agonists on HCA(2) -mediated flushing and VLDL-triglyceride levels in mice

scientific article published on October 2012

Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice

scientific article published on 03 April 2019

Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development.

scientific article

Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.

scientific article published in July 2016

FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice

scientific article published on 27 May 2012

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

scientific article published on 24 May 2007

Functionality of High-Density Lipoprotein as Antiatherosclerotic Therapeutic Target

scientific article published on 01 November 2016

Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I.

scientific article

Genetic variant of the scavenger receptor BI in humans

scientific article published on 01 January 2011

HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes

scientific article published in November 2005

HDL is essential for atherosclerotic lesion regression in Apoe knockout mice by bone marrow Apoe reconstitution

scientific article published on 04 October 2018

Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice

scientific article published on 30 December 2018

Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice.

scientific article published on 28 August 2007

Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis.

scientific article published on 18 June 2010

Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice

scientific article published on 22 September 2018

Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI

scientific article published on 27 July 2011

Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice.

scientific article published on 9 February 2007

Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL.

scientific article published on 23 August 2007

Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development

scientific article published on 23 January 2009

Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal Absorption of Cholesterol in Adult Mice

scientific article

Is prolactin involved in the evolution of atherothrombotic disease?

scientific article published on 01 May 2012

LR11/SorLA links triglyceride-rich lipoproteins to risk of developing cardiovascular disease in FH patients

scientific article published on 13 October 2015

Leukocytosis and enhanced susceptibility to endotoxemia but not atherosclerosis in adrenalectomized APOE knockout mice

scientific article

Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice.

scientific article

MicroRNA-499-5p: a therapeutic target in the context of cardiovascular disease.

scientific article published on December 2016

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing

scientific article published on 01 December 2014

Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice.

scientific article published on 27 June 2012

Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells

scientific article published on 29 January 2013

PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice

scientific article published on 25 December 2008

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

scientific article published on 14 July 2015

Prolactin receptor antagonism uncouples lipids from atherosclerosis susceptibility

scientific article published on 25 July 2014

Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model

scientific article published on 05 May 2018

Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor.

scientific article published on 15 March 2017

Response to the Letter by Singh et al Regarding “Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations”

Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency

scientific article

Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development.

scientific article

SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease.

scientific article published on 31 January 2017

Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo

scientific article published on 22 October 2007

Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice

scientific article

Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice

scientific article

The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

scientific article published on 07 December 2011

The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status

scientific article published on 24 November 2009

Total body ABCG1 expression protects against early atherosclerotic lesion development in mice

scientific article published on 04 January 2007

Total body proteoglycan 4 (Prg4) deficiency increases atherosclerosis susceptibility in apolipoprotein E knockout and low-density lipoprotein receptor knockout mice

scientific article published on 30 June 2018

List of works by Menno Hoekstra

Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice

Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice

Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT.

Adrenal-specific scavenger receptor BI deficiency induces glucocorticoid insufficiency and lowers plasma very-low-density and low-density lipoprotein levels in mice

Adrenalectomy stimulates the formation of initial atherosclerotic lesions: reversal by adrenal transplantation

Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations

Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype

Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice

Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE

Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Increases Hepatic ABCA1 mRNA Expression and HDL-Cholesterol

Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.

Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels

Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol

Effects of pyrazole partial agonists on HCA(2) -mediated flushing and VLDL-triglyceride levels in mice

Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice

Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development.

Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.

FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

Functionality of High-Density Lipoprotein as Antiatherosclerotic Therapeutic Target

Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I.

Genetic variant of the scavenger receptor BI in humans

HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes

HDL is essential for atherosclerotic lesion regression in Apoe knockout mice by bone marrow Apoe reconstitution

Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice

Hepatic cell-specific ATP-binding cassette (ABC) transporter profiling identifies putative novel candidates for lipid homeostasis in mice.

Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis.

Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice

Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI

Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice.

Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL.

Independent protective roles for macrophage Abcg1 and Apoe in the atherosclerotic lesion development

Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal Absorption of Cholesterol in Adult Mice

Is prolactin involved in the evolution of atherothrombotic disease?

LR11/SorLA links triglyceride-rich lipoproteins to risk of developing cardiovascular disease in FH patients

Leukocytosis and enhanced susceptibility to endotoxemia but not atherosclerosis in adrenalectomized APOE knockout mice

Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice.

MicroRNA-499-5p: a therapeutic target in the context of cardiovascular disease.

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing

Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice.

Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells

PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

Prolactin receptor antagonism uncouples lipids from atherosclerosis susceptibility

Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model

Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor.

Response to the Letter by Singh et al Regarding “Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations”

Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency

Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development.

SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease.

Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo

Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice

Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice

The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status

Total body ABCG1 expression protects against early atherosclerotic lesion development in mice

Total body proteoglycan 4 (Prg4) deficiency increases atherosclerosis susceptibility in apolipoprotein E knockout and low-density lipoprotein receptor knockout mice