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List of works by Aki T. Heikkinen

Analysis of unstirred water layer in in vitro permeability experiments.

scientific article published on December 2009

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.

scientific article published in July 2012

Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates.

scientific article published on 4 June 2007

Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments.

scientific article

Effects of experimental setup on the apparent concentration dependency of active efflux transport in in vitro cell permeation experiments.

scientific article

In vitro to in vivo extrapolation and physiologically based modeling of cytochrome P450 mediated metabolism in beagle dog gut wall and liver.

scientific article published on 13 March 2013

In vitro-in vivo correlation in P-glycoprotein mediated transport in intestinal absorption.

scientific article

Kinetics of cellular retention during Caco-2 permeation experiments: role of lysosomal sequestration and impact on permeability estimates

scientific article

Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.

scientific article

Modelling of drug disposition kinetics in in vitro intestinal absorption cell models.

scientific article published on 22 December 2009

Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions

scientific article published on 01 February 2020

Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics

scientific article published on 3 June 2007

The asymmetry of the unstirred water layer in permeability experiments

scientific article published on 16 April 2008

Transplacental transfer of nitrosodimethylamine in perfused human placenta

scientific article published on 11 February 2009

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