List of works - Pedro Cabrales

A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001.

scientific article

A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?

scientific article published on 26 May 2016

A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response

scientific article

Acute kidney function and morphology following topload administration of recombinant hemoglobin solution.

scientific article published on 31 October 2016

Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution

scientific article published on 9 December 2004

Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit ⬇️

scientific article published on August 24, 2012

Balance between vasoconstriction and enhanced oxygen delivery

scientific article published on 9 July 2008

Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states.

scientific article

Blood Quality Diagnostic Device Detects Storage Differences Between Donors.

scientific article

Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals.

scientific article published in January 2010

Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients.

scientific article published on January 2008

Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids.

scientific article published on July 2013

Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity

scientific article published on 3 March 2006

Blood viscosity: a factor in tissue survival?

scientific article

Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells.

scientific article

Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored?

scientific article published on 01 May 2006

Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic.

scientific article published on 24 November 2016

Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution

scientific article published on January 2010

Cardiac systolic function recovery after hemorrhage determines survivability during shock.

scientific article published on April 2011

Cardioprotective Effect of Phase 3 Clinical Anticancer Agent, RRx-001, in Doxorubicin-Induced Acute Cardiotoxicity in Mice

scientific article published on 03 June 2019

Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence.

scientific article published on January 2010

Cerebral tissue oxygenation impairment during experimental cerebral malaria.

scientific article published on 11 September 2013

Control of overweight and obesity in childhood through education in meal time habits. The 'good manners for a healthy future' programme

scientific article published on 15 December 2015

Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report.

scientific article published on 19 September 2016

Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin

scientific article published in March 2007

Delaying blood transfusion in experimental acute anemia with a perfluorocarbon emulsion.

scientific article

Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?

scientific article published on 01 March 2018

Doxorubicin-loaded red blood cells reduced cardiac toxicity and preserved anticancer activity

article

Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders.

scientific article published in July 2005

Effect of deformability difference between two erythrocytes on their aggregation.

scientific article published on 10 April 2013

Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery

scientific article published in October 2005

Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia.

scientific article published on 25 July 2014

Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia

scientific article published on 20 April 2007

Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure

scientific article published on 6 January 2005

Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*.

scientific article

Effects of plasma viscosity modulation on cardiac function during moderate hemodilution

scientific article published on July 2010

Effects on cardiac function of a novel low viscosity plasma expander based on polyethylene glycol conjugated albumin

scientific article published on July 1, 2011

Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion.

scientific article published on 2 December 2004

Emergent behaviors in RBCs flows in micro-channels using digital particle image velocimetry.

scientific article published on 13 September 2017

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

scientific article

Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties

scientific article

Examining and Mitigating Acellular Hemoglobin Vasoactivity ⬇️

scientific article published on October 11, 2012

Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue

scientific article published on 01 February 2007

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander ⬇️

scientific article published on October 26, 2011

Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice.

scientific article

Exogenous nitric oxide induces protection during hemorrhagic shock.

scientific article published on 10 April 2009

Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock

scientific article published on 20 February 2011

Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin

scientific article published on 15 July 2005

Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor

scientific article

From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

scientific article published on 28 May 2015

GBT1118, a potent allosteric modifier of hemoglobin O2 affinity, increases tolerance to severe hypoxia in mice.

scientific article published on 19 May 2017

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.

scientific article published on 13 April 2018

HBOC Vasoactivity: Interplay Between Nitric Oxide Scavenging and Capacity to Generate Bioactive Nitric Oxide Species ⬇️

scientific article published on February 12, 2013

Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin.

scientific article

Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin.

scientific article

Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood

scientific article

Hemorrhagic shock resuscitation with carbon monoxide saturated blood

scientific article published on 7 November 2006

Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation

scientific article published on 03 July 2019

Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock

scientific article published in November 2004

Hyperthermia during exercise - a double-edged sword.

scientific article published on 6 July 2016

Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration

scientific article

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001.

scientific article published on January 2016

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

scientific article published on 09 May 2016

Impact of enzymatic degradation of the endothelial glycocalyx on vascular permeability in an awake hamster model.

scientific article

Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock

scientific article

Implications Enzymatic Degradation of the Endothelial Glycocalyx on the Microvascular Hemodynamics and the Arteriolar Red Cell Free Layer of the Rat Cremaster Muscle.

scientific article published on 16 March 2018

Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model.

scientific article

Improving cardiac function with new-generation plasma volume expanders.

scientific article published on 3 August 2012

Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model

scientific article published on 17 February 2006

Increased hemoglobin O2 affinity protects during acute hypoxia.

scientific article

Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock.

scientific article published on 4 March 2008

Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin.

scientific article

Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat

scientific article published on 18 December 2015

Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model.

scientific article

Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

scientific article

Integration of cardiovascular regulation by the blood/endothelium cell‐free layer ⬇️

scientific article published on April 26, 2011

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window ⬇️

scientific article published on November 18, 2010

Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?

scientific article

Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction.

scientific article published on 03 October 2008

Localized increase of tissue oxygen tension by magnetic targeted drug delivery.

scientific article published on 12 June 2014

Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function

scientific article

Measurement of the cardiac output in small animals by thermodilution.

scientific article published on September 2003

Mechanotransduction and the homeostatic significance of maintaining blood viscosity in hypotension, hypertension and haemorrhage.

scientific article

Microcirculatory changes during chronic adaptation to hypoxia.

scientific article published in November 2003

Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model.

scientific article published in June 2009

Microhemodynamic aberrations created by transfusion of stored blood.

scientific article

Microhemodynamic parameters quantification from intravital microscopy videos.

scientific article

Microlymphatic and tissue oxygen tension in the rat mesentery.

scientific article

Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber

scientific article

Microvascular and capillary perfusion following glycocalyx degradation

scientific article published on 8 March 2007

Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution

scientific article published in April 2007

Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia

scientific article published in January 2006

Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation.

scientific article published on 4 May 2008

Microvascular oxygen delivery and consumption following treatment with verapamil

scientific article published on 24 November 2004

Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions.

scientific article published in November 2004

Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier.

scientific article published on 19 February 2004

Mixtures of tense and relaxed state polymerized human hemoglobin regulate oxygen affinity and tissue construct oxygenation

scientific article

Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine

scientific article

NO supplementation for transfusion medicine and cardiovascular applications

scientific article

Nanoengineering bactericidal nitric oxide therapies ⬇️

scientific article published on 01 May 2011

Navigating the "No Man's Land" of TKI-Failed EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC): A Review.

scientific article

New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions

scientific article published on 01 May 2007

Nitric Oxide Protection Against Murine Cerebral Malaria Is Associated With Improved Cerebral Microcirculatory Physiology ⬇️

scientific article published on March 16, 2011

Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia

scientific article published on 15 December 2005

Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria

scientific article (publication date: 2013)

Nitric oxide synthase inhibition attenuates cardiac response to hemodilution with viscogenic plasma expander.

scientific article

Nonlinear cardiovascular regulation consequent to changes in blood viscosity.

scientific article published on January 2011

Notch-independent RBPJ controls angiogenesis in the adult heart

scientific article published on 30 June 2016

Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin.

scientific article

Oxygen distribution and respiration by the microcirculation

scientific article

Oxygen release from arterioles with normal flow and no-flow conditions

scientific article

Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model

scientific article

Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution.

scientific article published on 24 November 2004

Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxia

scientific article published on 5 June 2008

PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning ⬇️

scientific article published on April 13, 2012

Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets.

scientific article published on 24 May 2016

Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization

scientific article published on 28 January 2016

Partial response to carboplatin in an RRx-001 pretreated patient with EGFR-inhibitor-resistance and T790M-negative NSCLC.

scientific article published on 24 April 2016

Perfluorocarbon in microcirculation during ischemia reperfusion.

scientific article

Perfusion pressure and blood flow determine microvascular apparent viscosity.

scientific article

Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage ⬇️

scientific article published on May 3, 2012

Plasma expander viscosity effects on red cell-free layer thickness after moderate hemodilution.

scientific article published in January 2011

Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions

scientific article

Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery.

scientific article

Polyethylene Glycol Camouflaged Earthworm Hemoglobin.

scientific article

Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters

scientific article

Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity

scientific article

Prediction of Recovery From Severe Hemorrhagic Shock Using Logistic Regression

scientific article published on 01 July 2019

Prospects for Human Erythrocyte Skeleton-Bilayer Dissociation during Splenic Flow

scientific article

RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor.

scientific article

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets

scientific article published on January 2016

RRx-001 protects against cisplatin-induced toxicities.

scientific article published on 17 April 2017

RRx-001, A novel dinitroazetidine radiosensitizer

scientific article

RRx-001, a novel clinical-stage chemosensitizer, radiosensitizer, and immunosensitizer, inhibits glucose 6-phosphate dehydrogenase in human tumor cells

scientific article

RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors

scientific article published on 11 May 2016

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

scientific article published on 9 December 2016

Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile.

scientific article published on 13 November 2003

Rat red blood cell storage lesions in various additive solutions.

scientific article published on 3 June 2017

Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel

scientific article published on 28 February 2019

Red blood cells flows in rectilinear microfluidic chip.

scientific article published in August 2015

Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies

scientific article

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood.

scientific article

Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin

scientific article published in October 2004

Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes

scientific article

Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide

scientific article

Rockets, radiosensitizers, and RRx-001: an origin story part I.

scientific article published on March 2016

Role of endothelial nitric oxide in microvascular oxygen delivery and consumption

scientific article published on 01 November 2005

S-nitrosoglutathione prevents experimental cerebral malaria

scientific article published on 6 March 2012

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study.

scientific article published on 19 August 2015

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease

scientific article

Simulation of NO and O2 transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production

scientific article published on 9 January 2012

Small-volume resuscitation from hemorrhagic shock using high-molecular-weight tense-state polymerized hemoglobins

scientific article published in October 2011

Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin ⬇️

scientific article published on November 17, 2011

Sustained release nitric oxide from long-lived circulating nanoparticles

scientific article published on 9 May 2010

Synthesis and biophysical properties of polymerized human serum albumin

scientific article published on 6 January 2011

Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity.

scientific article

Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation.

scientific article published on 4 July 2016

Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2.

scientific article

The vascular wall as a regulator of tissue oxygenation.

scientific article

Time-dependant oxygen partial pressure in capillaries and tissue in the hamster window chamber model

scientific article published in July 2007

Tissue oxidative metabolism after extreme hemodilution with PEG-conjugated hemoglobin ⬇️

scientific article published on September 2, 2010

Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy

scientific article

Transport of nitric oxide by perfluorocarbon emulsion

scientific article

Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity

scientific article published on 20 August 2020

Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents

scientific article

Two-phase model for prediction of cell-free layer width in blood flow ⬇️

scientific article published on October 29, 2012

Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin.

scientific article published on 14 July 2008

What determines blood viscosity at the highest city in the world?

scientific article published on 22 July 2020

Will fixing the vasoactivity caused by hemoglobin-based oxygen carriers be enough?

scientific article published in June 2009

List of works by Pedro Cabrales

A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001.

A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?

A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response

Acute kidney function and morphology following topload administration of recombinant hemoglobin solution.

Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution

Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit ⬇️

Balance between vasoconstriction and enhanced oxygen delivery

Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states.

Blood Quality Diagnostic Device Detects Storage Differences Between Donors.

Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals.

Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients.

Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids.

Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity

Blood viscosity: a factor in tissue survival?

Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells.

Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored?

Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic.

Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution

Cardiac systolic function recovery after hemorrhage determines survivability during shock.

Cardioprotective Effect of Phase 3 Clinical Anticancer Agent, RRx-001, in Doxorubicin-Induced Acute Cardiotoxicity in Mice

Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence.

Cerebral tissue oxygenation impairment during experimental cerebral malaria.

Control of overweight and obesity in childhood through education in meal time habits. The 'good manners for a healthy future' programme

Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report.

Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin

Delaying blood transfusion in experimental acute anemia with a perfluorocarbon emulsion.

Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?

Doxorubicin-loaded red blood cells reduced cardiac toxicity and preserved anticancer activity

Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders.

Effect of deformability difference between two erythrocytes on their aggregation.

Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery

Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia.

Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia

Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure

Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*.

Effects of plasma viscosity modulation on cardiac function during moderate hemodilution

Effects on cardiac function of a novel low viscosity plasma expander based on polyethylene glycol conjugated albumin

Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion.

Emergent behaviors in RBCs flows in micro-channels using digital particle image velocimetry.

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties

Examining and Mitigating Acellular Hemoglobin Vasoactivity ⬇️

Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander ⬇️

Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice.

Exogenous nitric oxide induces protection during hemorrhagic shock.

Exogenous nitric oxide prevents cardiovascular collapse during hemorrhagic shock

Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin

Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor

From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

GBT1118, a potent allosteric modifier of hemoglobin O2 affinity, increases tolerance to severe hypoxia in mice.

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.

HBOC Vasoactivity: Interplay Between Nitric Oxide Scavenging and Capacity to Generate Bioactive Nitric Oxide Species ⬇️

Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin.

Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin.

Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood

Hemorrhagic shock resuscitation with carbon monoxide saturated blood

Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation

Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock

Hyperthermia during exercise - a double-edged sword.

Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001.

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Impact of enzymatic degradation of the endothelial glycocalyx on vascular permeability in an awake hamster model.

Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock

Implications Enzymatic Degradation of the Endothelial Glycocalyx on the Microvascular Hemodynamics and the Arteriolar Red Cell Free Layer of the Rat Cremaster Muscle.

Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model.

Improving cardiac function with new-generation plasma volume expanders.

Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model

Increased hemoglobin O2 affinity protects during acute hypoxia.

Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock.

Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin.

Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat

Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model.

Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

Integration of cardiovascular regulation by the blood/endothelium cell‐free layer ⬇️

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window ⬇️

Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?

Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction.