List of works - Miriam Cnop

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

scientific article

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

scientific article published on 16 March 2015

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells

scientific article published on October 2008

BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells

scientific article published on 5 August 2006

Beta cell imaging - a key tool in optimized diabetes prevention and treatment

scientific article published on 11 April 2014

Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

scientific article published in July 2002

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

scientific article published on October 2010

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

scientific article published on December 2012

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

scientific article published on 26 August 2020

Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients

scientific article published on 29 September 2011

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

scientific article published on 31 January 2012

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

scientific article

Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance

scientific article published on 12 January 2012

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease

scientific article

Diabetes in Friedreich ataxia

scientific article published on August 2013

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

scientific article published on 10 February 2020

ER stress in pancreatic beta cells: the thin red line between adaptation and failure

scientific article published on 23 February 2010

Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.

scientific article published on January 2000

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

scientific article published on 12 July 2017

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

scientific journal article

Endoplasmic reticulum stress, obesity and diabetes

scientific article published on 31 August 2011

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

scientific article

Epigenetic aspects of pancreatic beta cell function in type 2 diabetes

scientific article published on 6 June 2014

Erratum

scholarly article published in Autophagy

Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scholarly article published in Diabetologia

Expression of adiponectin receptors in pancreatic beta cells

scientific article

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

scientific article published on June 2008

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

scientific article published on 5 August 2004

Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia

scientific article published on 17 April 2009

Future Perspectives for the Treatment of Diabetes: Importance of a Regulatory Framework

scientific article published on 03 September 2018

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

scientific journal article

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

scientific article published on 31 August 2009

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach

scientific article

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

scientific article

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

scientific article published in February 2003

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

scientific article published in December 2018

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

scientific article published on 17 June 2008

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

scientific article published on 26 May 2021

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

scientific article published in August 2001

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

scientific article

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

scientific article published in November 2001

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway

scientific article

Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease

scientific article published in September 2011

Longevity of human islet α- and β-cells

scientific article published on October 2011

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

scientific article published on 6 July 2007

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification

scientific article published in September 2002

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

scientific article

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

scientific article

Mining Genes in Type 2 Diabetic Islets and Finding Gold

scientific article published in November 2012

Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in in vitro and in vivo models

scientific article published on 10 January 2020

Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn

scientific article published in January 2010

OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia

Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid

scientific article

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

scientific article published on 31 March 2009

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scientific article

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

scientific article published on 18 October 2017

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

scientific article published on 17 March 2015

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

scientific article published on 12 May 2020

Perioperative Management of Oral Glucose-lowering Drugs in the Patient with Type 2 Diabetes

scientific article published on 01 August 2020

Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

scientific article

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

scientific article published in March 2007

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

scientific article published on 30 December 2013

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

scientific article published on 16 October 2019

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

scientific article published on 10 April 2003

Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction

scientific article

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

scientific journal article

The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

scientific article

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.

scientific article published in April 2002

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice

scientific article published on 9 January 2003

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

scientific article

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

scientific article

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

scientific article published on 24 October 2009

The role for endoplasmic reticulum stress in diabetes mellitus

scientific article

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

scientific article published on 01 May 2019

The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses

scientific article published on 29 December 2010

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

scientific article published on April 2007

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction

scientific article published on 22 June 2009

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity

scientific article published in April 2002

Type 2 diabetes mellitus--an autoimmune disease?

scientific article

Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis

scientific journal article

Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia

scientific article

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

scientific article published on 06 January 2021

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans

scientific article

List of works by Miriam Cnop

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells

BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells

Beta cell imaging - a key tool in optimized diabetes prevention and treatment

Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S.

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease

Diabetes in Friedreich ataxia

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

ER stress in pancreatic beta cells: the thin red line between adaptation and failure

Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

Endoplasmic reticulum stress, obesity and diabetes

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

Epigenetic aspects of pancreatic beta cell function in type 2 diabetes

Erratum

Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

Expression of adiponectin receptors in pancreatic beta cells

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia

Future Perspectives for the Treatment of Diabetes: Importance of a Regulatory Framework

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway

Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease

Longevity of human islet α- and β-cells

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

Low density lipoprotein can cause death of islet beta-cells by its cellular uptake and oxidative modification

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

Mining Genes in Type 2 Diabetic Islets and Finding Gold

Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in in vitro and in vivo models

Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn

OGTT is recommended for glucose homeostasis assessments in Friedreich ataxia

Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Perioperative Management of Oral Glucose-lowering Drugs in the Patient with Type 2 Diabetes

Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat.

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

The role for endoplasmic reticulum stress in diabetes mellitus

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity