List of works - Christiane S Hampe

A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples

scientific article published in April 2006

A novel monoclonal antibody specific for the N-terminal end of GAD65.

scientific article

A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome

scientific article published on 19 February 2009

Accuracy and predictive value of classification schemes for ketosis-prone diabetes

scientific article published on 01 December 2006

Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin.

scientific article

Anti-idiotypic antibody specific to GAD65 autoantibody prevents type 1 diabetes in the NOD mouse

scientific article

Antibodies to GAD65 and peripheral nerve function in the DCCT.

scientific article

Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010-2011 winter viral seasons in Israel: a pilot study.

scientific article

Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein

scientific article published on 7 March 2008

Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes

scientific article published on 6 April 2014

Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitus

scientific article published on 7 November 2006

Autoantibodies in diabetes

scientific article

Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles

scientific article published on 22 October 2007

B Cell in Autoimmune Diseases

scientific article published on January 2012

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

scientific article published on 09 January 2008

Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals

scientific article published on 01 March 2013

Characteristics of patients with ketosis-prone diabetes (KPD) presenting with acute pancreatitis: implications for the natural history and etiology of a KPD subgroup

scientific article published in March 2013

Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes

scientific article

Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function.

scientific article

Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies

scientific article published on 23 September 2009

Conformation-dependent GAD65 autoantibodies in diabetes

scientific article published on 8 September 2004

Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias

scientific article

Control of insulin secretion by cytochrome C and calcium signaling in islets with impaired metabolism

scientific article

DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes

scientific article

Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes

scientific article

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death

scientific article

Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein

scientific article

Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus

scientific article

Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

scientific article

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes

scientific article published on 16 April 2005

Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial.

scientific article

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome

scientific article published on 16 June 2015

Encephalitis associated with glutamic acid decarboxylase autoantibodies in a child: a treatable condition?

scientific article published on August 2011

Engineered antibodies for type 1 diabetes.

scientific article published on April 2009

Epilepsy and behavioral changes, type 1 diabetes mellitus and a high titer of glutamic acid decarboxylase antibodies

scientific article published on 29 December 2015

Epitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes

scientific article published on 01 November 2007

Epitope analysis of GAD65Ab using fusion proteins and rFab

scientific article published on 30 October 2004

Epitope analysis of insulin autoantibodies using recombinant Fab.

scientific article published in June 2005

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes

scientific article published in November 2004

Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations.

scientific article

Factors associated with early relapse to insulin dependence in unprovoked A-β+ ketosis-prone diabetes

scientific article

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

scientific article

GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes

scientific article published on 16 August 2011

GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response

article

GAD65 Antibody Epitope Patterns of Type 1.5 Diabetic Patients Are Consistent With Slow-Onset Autoimmune Diabetes

scientific article published on 01 August 2002

GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat

scientific article published on 01 January 1999

GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitus

scientific article published on August 2011

GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination

scientific article published on 15 March 2007

GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patients

scientific article published on 16 May 2008

Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes

scientific article published on 01 October 1999

Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index.

scientific article

HLA class II alleles specify phenotypes of ketosis-prone diabetes

scientific article published on 3 March 2008

High titers of autoantibodies to glutamate decarboxylase in type 1 diabetes patients: epitope analysis and inhibition of enzyme activity

scientific article

Immune reactivity to GAD25 in type 1 diabetes mellitus

scientific article

Immunobiology of stiff-person syndrome

scientific article published on January 2008

Influence of codon context on UGA suppression and readthrough

scientific article published on May 20, 1992

Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?

scientific article

Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia.

scientific article

Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes

scientific article published on 15 October 2013

Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes

scientific article published in November 2003

Latent autoimmune diabetes in an adult

scientific article

Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person Syndrome

scientific article

Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes

scientific article published on 01 April 2007

Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes

scientific article published on 01 October 2006

Masked and overt autoantibodies specific to the DPD epitope of 65-kDa glutamate decarboxylase (GAD65-DPD) are associated with preserved β-cell functional reserve in ketosis-prone diabetes

scientific article

Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies

scientific article published in April 2008

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

scientific article

Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay

scientific article published in August 2003

Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats

scientific article

Multiplicity of the antibody response to GAD65 in Type I diabetes

scientific article published on 01 November 2004

Neuronal central nervous system syndromes probably mediated by autoantibodies

scientific article

O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells.

scientific article published on 11 July 2013

Pathogenesis of A⁻β⁺ ketosis-prone diabetes

scientific article published on 16 November 2012

Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain

scientific article

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

scientific article published on 27 March 2015

Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of "A-β+" ketosis-prone diabetes based on long-term β-cell function, human leukocyte antigen class II alleles, and sex predilection

scientific article

Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.

scientific article published in January 2001

Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study

scientific article published on August 2015

Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial

scientific article published on 06 June 2006

Protective role of anti-idiotypic antibodies in autoimmunity – Lessons for type 1 diabetes ⬇️

scientific article published on February 23, 2012

Purification and preliminary characterization of an Fc epsilon-receptor-activated protein-tyrosine phosphatase from mast cells.

scientific article

Quantitative evaluation of a monoclonal antibody and its fragment as potential markers for pancreatic beta cell mass

scientific article published in July 2005

Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes

scientific article

Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs

scientific article published on 01 November 2003

Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus

scientific article published on 28 December 2018

Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia

scientific article

Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals with lesser or no beta-cell autoimmunity

scientific article published on 23 November 2007

Serum adiposity-induced biomarkers in obese and lean children with recently diagnosed autoimmune type 1 diabetes

scientific article published on 30 June 2014

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.

scientific article

Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays

scientific article published on 14 December 2006

Species-specific autoantibodies in type 1 diabetes

scientific article published on 01 February 1999

Stability of disease-associated antibody titers in pregnant women with type 1 diabetes with or without residual beta-cell function

scientific article published on 01 July 2000

Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset

scientific article published on 01 February 2002

Syndromes of ketosis-prone diabetes mellitus

scientific article

The GABAergic septohippocampal pathway is directly involved in internal processes related to operant reward learning

scientific article published on 10 March 2013

The blood brain barrier and the role of ratiometric molecular analysis in schizophrenia

scientific article

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

scholarly article

Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves' disease

scientific article published on 29 April 2013

ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset

scientific article published on 19 March 2010

List of works by Christiane S Hampe

A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples

A novel monoclonal antibody specific for the N-terminal end of GAD65.

A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome

Accuracy and predictive value of classification schemes for ketosis-prone diabetes

Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin.

Anti-idiotypic antibody specific to GAD65 autoantibody prevents type 1 diabetes in the NOD mouse

Antibodies to GAD65 and peripheral nerve function in the DCCT.

Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010-2011 winter viral seasons in Israel: a pilot study.

Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein

Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes

Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitus

Autoantibodies in diabetes

Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles

B Cell in Autoimmune Diseases

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals

Characteristics of patients with ketosis-prone diabetes (KPD) presenting with acute pancreatitis: implications for the natural history and etiology of a KPD subgroup

Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes

Clonal relationships between thyroid-stimulating hormone receptor-stimulating antibodies illustrate the effect of hypermutation on antibody function.

Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies

Conformation-dependent GAD65 autoantibodies in diabetes

Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias

Control of insulin secretion by cytochrome C and calcium signaling in islets with impaired metabolism

DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes

Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death

Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein

Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus

Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes

Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial.

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome

Encephalitis associated with glutamic acid decarboxylase autoantibodies in a child: a treatable condition?

Engineered antibodies for type 1 diabetes.

Epilepsy and behavioral changes, type 1 diabetes mellitus and a high titer of glutamic acid decarboxylase antibodies

Epitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes

Epitope analysis of GAD65Ab using fusion proteins and rFab

Epitope analysis of insulin autoantibodies using recombinant Fab.

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes

Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations.

Factors associated with early relapse to insulin dependence in unprovoked A-β+ ketosis-prone diabetes

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes

GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response

GAD65 Antibody Epitope Patterns of Type 1.5 Diabetic Patients Are Consistent With Slow-Onset Autoimmune Diabetes

GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat

GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitus

GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination

GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patients

Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes

Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index.

HLA class II alleles specify phenotypes of ketosis-prone diabetes

High titers of autoantibodies to glutamate decarboxylase in type 1 diabetes patients: epitope analysis and inhibition of enzyme activity

Immune reactivity to GAD25 in type 1 diabetes mellitus

Immunobiology of stiff-person syndrome

Influence of codon context on UGA suppression and readthrough

Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?

Islet cell autoantibodies in cord blood from children with blood group incompatibility or hyperbilirubinemia.

Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes

Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes

Latent autoimmune diabetes in an adult

Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person Syndrome

Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes

Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes

Masked and overt autoantibodies specific to the DPD epitope of 65-kDa glutamate decarboxylase (GAD65-DPD) are associated with preserved β-cell functional reserve in ketosis-prone diabetes

Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

Molecular engineering of biotin-glutamic acid decarboxylase 65 fusion protein (Biotin-GAD65) for non-radioactive GAD65 antibody assay

Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats

Multiplicity of the antibody response to GAD65 in Type I diabetes

Neuronal central nervous system syndromes probably mediated by autoantibodies

O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells.

Pathogenesis of A⁻β⁺ ketosis-prone diabetes

Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of "A-β+" ketosis-prone diabetes based on long-term β-cell function, human leukocyte antigen class II alleles, and sex predilection

Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.

Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study

Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial