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List of works by Neil M Walker

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

scientific article

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

scientific article

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

scientific article

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

scientific article

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility

scientific article published in June 2002

All or Nothing: The False Promise of Anonymity

All or Nothing: the False Promise of Anonymity

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

article

Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

scientific article

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

scientific article

Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing

article

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

scientific article

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

scientific article published in March 2004

Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes

scientific article published in October 2004

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes

scientific article (publication date: February 2005)

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes

scientific article published on 3 April 2006

Association of intercellular adhesion molecule-1 gene with type 1 diabetes

scientific article published on November 2003

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

scientific article (publication date: 29 May 2003)

Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes

scientific article published on 2 July 2007

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

scientific article

Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure

scientific article published on 26 April 2018

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

scientific article published on 18 July 2017

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

scientific article published on 23 August 2009

Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene

scientific article

Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.

scientific article published on February 2009

Confirmation of novel type 1 diabetes risk loci in families

scientific article

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

scientific article

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes

scientific article

Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics

scientific article

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes

scientific article published on 20 April 2006

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

scientific article

Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).

scientific article

Erratum: Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

scientific article published on 01 August 2015

Evidence of association with type 1 diabetes in the SLC11A1 gene region.

scientific article

Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes

scientific article

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.

scientific article

Experimental aspects of copy number variant assays at CCL3L1

scientific article

FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection

scientific article

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

scientific article

Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.

scientific article

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

scientific article

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

scientific article

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

scientific article

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

scientific article

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article

Growth rates and risk of rupture of abdominal aortic aneurysms

scientific article published in December 1998

Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.

scientific article

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

scientific article

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

scientific article

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

scientific article published on 25 March 2011

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes

article

Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping

scientific article

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

scientific article

Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm

scientific article published on 01 July 2002

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

scientific article

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

scientific article

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

scientific article published on 11 October 2011

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

scientific article

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

scientific article

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

scientific article

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

scientific article published on 17 August 2017

No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases

article

No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility

article

No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes

scientific article published in June 2005

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes

scientific article

Parameters for reliable results in genetic association studies in common disease

article

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

scientific article

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

scientific article

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

scientific article published on 15 February 2013

Prepublication data sharing

scientific article

Probabilities of progression of aortic aneurysms: estimates and implications for screening policy

scientific article published in January 2002

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

scientific article

Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm

scientific article published on 01 February 2000

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

scientific article

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

scientific article

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial

scientific article

Reduced expression of IFIH1 is protective for type 1 diabetes

scientific article

Regression mapping of association between the human leukocyte antigen region and Graves disease

scientific article published on 22 November 2004

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

scientific article

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

scientific article

Returning findings within longitudinal cohort studies: the 1958 birth cohort as an exemplar

scientific article

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

scientific article

Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.

scientific article

Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.

scientific article

Seven newly identified loci for autoimmune thyroid disease

scientific article

Shared and distinct genetic variants in type 1 diabetes and celiac disease

scientific article

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

scientific article published on 8 June 2015

T1DBase, a community web-based resource for type 1 diabetes research

scientific article

T1DBase: integration and presentation of complex data for type 1 diabetes research

scientific article

Targeting regulatory T cells with Interleukin-2 treatment in type 1 diabetes: a response-adaptive, non-randomised, open-label trial of repeat doses of Aldesleukin (DILfrequency)

Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.

scientific article published in October 2003

The Gothenburg Breast Screening Trial

scientific article published in May 2003

The Long-term Benefits of a Single Scan for Abdominal Aortic Aneurysm (AAA) at Age 65

scientific article published on 01 June 2001

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

scientific article

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

scientific article

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

scientific article

Type 1 diabetes genome-wide association analysis with imputation identifies five new risk regions

Validity of the family-based association test for copy number variant data in the case of non-linear intensity-genotype relationship.

scientific article

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