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List of works by Frederick R. Maxfield

A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo

scientific article published on 17 January 2018

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele

scientific article published on May 2015

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

scientific article

Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.

scientific article published on 25 June 2009

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface ⬇️

scientific article published on February 22, 1979

An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells.

scientific article

Analysis of Cholesterol Trafficking with Fluorescent Probes ⬇️

scientific article published on January 1, 2012

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells

scientific article published on 15 November 2005

Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling

scientific article published on 01 May 1997

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.

scientific article published on 24 March 2014

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells

scientific article

Cholesterol trafficking and distribution

scientific article published on 01 January 2015

Cholesterol, the central lipid of mammalian cells

scientific article

Cholesterol-dependent retention of GPI-anchored proteins in endosomes ⬇️

scientific article published on August 17, 1998

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization ⬇️

scientific article published on August 1, 1978

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

scientific article

Comment on 'Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol'

scientific article published on 13 November 2018

Cyclized dipeptide model for a beta-bend ⬇️

scientific article published on June 1, 1979

Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling

scientific article

Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages.

scientific article

Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells

scientific article published on 16 December 2003

Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis

scientific article published on 02 December 2019

Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells

scientific article

Effect of primary amines on interferon action

scientific article published on 01 March 1982

Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices

scientific article published on 01 May 1997

Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.

scientific article published on 20 January 2004

Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia.

scientific article published in June 2000

Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary

scientific article

Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation

scientific article published on 10 May 2007

Elevated plasma membrane cholesterol content alters macrophage signaling and function.

scientific article published on 23 November 2005

Endocytic recycling

scientific article (publication date: February 2004)

Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails.

scientific article

Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to thetrans-Golgi Network and a Subpopulation of Late Endosomes ⬇️

scientific article published on October 31, 2003

Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits

scientific article published on November 1, 1979

Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells.

scientific article

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.

scientific article

Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin.

scientific article

Flotillas of lipid rafts fore and aft.

scientific article

Fluorescence imaging in living animals. Focus on "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy".

scientific article published in August 2004

High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation

scientific article published on 02 December 2019

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts ⬇️

scientific article published on March 21, 2011

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.

scientific article published on 13 February 2017

Human bladder cancer diagnosis using Multiphoton microscopy

scientific article

Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages

scientific article published in Journal of Biological Chemistry

Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect

scientific article

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

scientific article published on 27 May 2021

Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization ⬇️

scientific article published on June 13, 1979

Intracellular sterol dynamics

scientific article published on 12 March 2009

Intracellular sterol transport and distribution.

scientific article published on 27 June 2006

Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

scientific article published on October 2009

Lipid and cholesterol trafficking in NPC.

scientific article published in October 2004

Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis

scientific article published on 01 February 1990

Membrane domains.

scientific article published in January 2004

Membrane lipid organization is critical for human neutrophil polarization.

scientific article

Membrane transport in the endocytic pathway

scientific article (publication date: August 1995)

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

scientific article published in September 1996

Microtubule asymmetry during neutrophil polarization and migration.

scientific article

Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol

scientific article published on 21 September 2006

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation

scientific article

Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery

scientific article

Multiphoton microscopy in the evaluation of human bladder biopsies

scientific article published on May 2012

Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy

scientific article

Niemann‐Pick type C disease: molecular mechanisms and potential therapeutic approaches ⬇️

scientific article published on 07 January 2011

Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.

scientific article published on 11 December 2014

Oxalic acid alters intracellular calcium in endothelial cells

scientific article published in April 2004

Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays.

scientific article

Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

scientific article published on 01 February 1991

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control

scholarly article

Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy

scientific article

Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts ⬇️

scientific article published on June 1, 1980

Regulation of endocytic processes by pH.

scientific article published on June 1988

Regulation of leukocyte locomotion by Ca2+.

scientific article published on November 1993

Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

scientific journal article

Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic

scientific article published on 23 February 2007

Role of endosomes and lysosomes in human disease.

scientific article published on May 2014

SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.

scientific article published on 2 November 2007

STARD4 Membrane Interactions and Sterol Binding.

scientific article published on 22 July 2015

STARD4 abundance regulates sterol transport and sensing

scientific article

STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC ⬇️

scientific article published on October 2, 2012

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

scientific article published in November 1997

Sphingomyelinase Treatment Induces ATP-independent Endocytosis ⬇️

scientific article published on January 12, 1998

Sphingosine kinases are not required for inflammatory responses in macrophages

scientific article published on 30 September 2013

Sterol, protein and lipid trafficking in Chinese hamster ovary cells with Niemann-Pick type C1 defect

scientific article published on 7 December 2006

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

scientific article published in Nature

The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis.

scientific article published on 26 August 2003

The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent.

scientific article published on June 1996

The endocytic pathway in microglia during health, aging and Alzheimer's disease

scientific article

The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells

scientific article published in July 2007

The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity.

scientific article published on 26 July 2001

Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGN

scientific article

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

scientific article published in Nature

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

scientific article published on August 1995

Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.

scientific article

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

scientific article published in November 1999

Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle

scientific article published on 26 October 2001

Yolk platelets in Xenopus oocytes maintain an acidic internal pH which may be essential for sodium accumulation

scientific article

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