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List of works by Francesco Andreozzi

3'-UTR OLR1/LOX-1 gene polymorphism and endothelial dysfunction: molecular and vascular data in never-treated hypertensive patients

scientific article

A fasting insulin-raising allele at IGF1 locus is associated with circulating levels of IGF-1 and insulin sensitivity

scientific article

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease

scientific article

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity

scientific article (publication date: 2012)

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients

scientific article published on 13 August 2019

A polymorphism at IGF1 locus is associated with anemia

scientific article published on 11 March 2017

A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation

scientific article published on 31 October 2013

Abnormal glucose transport and GLUT1 cell-surface content in fibroblasts and skeletal muscle from NIDDM and obese subjects.

scientific article published on April 1997

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-ce

scientific article published on 4 March 2004

Angiotensin (1-7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs.

scientific article published on 21 March 2013

Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells

scientific article published on 25 March 2004

Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs.

scientific article published on 3 September 2011

Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes

scientific article published on August 2013

Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals.

scientific article

C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.

scientific article published in August 2005

Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.

scientific article published on 12 September 2006

Characterization of left ventricular mass in individuals at risk for type 2 diabetes identified by HbA1c levels according to the American Diabetes Association criteria

scientific article published on 06 November 2014

Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN β‐cell line and human islets of Langerhans ⬇️

scientific article published on May 8, 2003

Comparison of A1C, fasting and 2-h post-load plasma glucose criteria to diagnose diabetes in Italian Caucasians.

scientific article published on 23 September 2011

Dietary patterns and 1-h post-load glucose in essential hypertension.

scientific article published on 3 December 2013

Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels.

scientific article published in May 2009

Different Patterns of Left Ventricular Hypertrophy in Metabolically Healthy and Insulin-Resistant Obese Subjects

scientific article published on 05 February 2020

Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes: the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study.

scientific article published on 28 November 2011

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

scientific article

Effects of glucagon-like peptide-1 receptor agonists on mortality and cardiovascular events: A comprehensive meta-analysis of randomized controlled trials

scientific article published on 05 May 2017

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

scientific article published on 2 June 2017

Elevated 1-h post-load plasma glucose levels in subjects with normal glucose tolerance are associated with a pro-atherogenic lipid profile

scientific article published on 17 November 2016

Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension

scientific article published on 10 October 2007

Endothelial dysfunction and non-alcoholic liver steatosis in hypertensive patients

scientific article published on 12 March 2010

Endothelial dysfunction, ADMA and insulin resistance in essential hypertension

scientific article published on 24 January 2009

Frequency of 1-h post-load glucose ≥155 mg/dl among individuals with different glucose tolerance conditions.

scientific article published on 3 February 2016

Glucagon-like peptide-1 receptor agonists and atrial fibrillation: a systematic review and meta-analysis of randomised controlled trials

scientific article published on 31 May 2017

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.

scientific article

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

scientific article published on 14 January 2011

Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes

scientific article published in October 2007

Gly460Trp alpha-adducin gene polymorphism and endothelial function in untreated hypertensive patients.

scientific article published in November 2007

Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels.

scientific article published on 21 April 2017

Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk

scientific article published on 01 May 2007

High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects

scientific article published on 12 March 2014

IGF-1 levels link estimated glomerular filtration rate to insulin resistance in obesity: a study in obese, but metabolically healthy, subjects and obese, insulin-resistant subjects

scientific article published on 3 August 2010

IL-18 gene polymorphism and metabolic syndrome

scientific article published on 26 January 2009

Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet

scientific article published on 28 June 2005

Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database

scientific article published in February 2008

Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells

scientific article published in April 2004

Increased carotid intima-media thickness in the physiologic range is associated with impaired postprandial glucose metabolism, insulin resistance and beta cell dysfunction.

scientific article published on 6 June 2013

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.

scientific article published on April 2011

Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes

scientific article published on 17 July 2015

Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals.

scientific article published on 12 June 2008

Insulin-Activated Protein Kinase Cβ Bypasses Ras and Stimulates Mitogen-Activated Protein Kinase Activity and Cell Proliferation in Muscle Cells

Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.

scientific article

Insulin-like growth factor-1 and glomerular filtration rate in hypertensive patients

scientific article published in March 2009

Insulin-like growth factor-1 is a negative modulator of glucagon secretion

scientific article published on 16 June 2017

Interaction between vascular dysfunction and cardiac mass increases the risk of cardiovascular outcomes in essential hypertension.

scientific article

Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells

scientific article published on 22 January 2007

Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

scientific article

Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein.

scientific article published on 9 April 2009

Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects.

scientific article published on 3 January 2017

Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects.

scientific article published on 18 July 2014

Low insulin-like growth factor-1 levels are associated with anaemia in adult non-diabetic subjects

scientific article published on 5 November 2010

Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects.

scientific article published on 5 April 2009

Low-plasma insulin-like growth factor-I levels are associated with impaired endothelium-dependent vasodilatation in a cohort of untreated, hypertensive Caucasian subjects

scientific article published on 22 April 2008

Metabolic and cardiovascular risk factors in subjects with impaired fasting glucose: the 100 versus 110 mg/dL threshold

scientific article published in October 2007

Metabolically Healthy but Obese Women Have an Intermediate Cardiovascular Risk Profile Between Healthy Nonobese Women and Obese Insulin-Resistant Women

scientific article published on 16 May 2007

Microvascular effects of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled trials

scientific article published on 27 July 2017

Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor-I.

scientific article

One-Hour Postload Hyperglycemia Confers Higher Risk of Hepatic Steatosis to HbA1c-Defined Prediabetic Subjects.

scientific article published on 26 July 2016

One-Hour Postload Hyperglycemia Is a Stronger Predictor of Type 2 Diabetes Than Impaired Fasting Glucose

scientific article published on 14 August 2015

One-hour post-load hyperglycemia combined with HbA1c identifies pre-diabetic individuals with a higher cardio-metabolic risk burden

scientific article published on 25 August 2016

One-hour post-load plasma glucose levels are associated with elevated liver enzymes

scientific article published on 20 July 2011

PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases

scientific article

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine

scientific article published on 07 January 2019

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

scientific article

Plasma complement C3 levels are associated with insulin secretion independently of adiposity measures in non-diabetic individuals

scientific article published on 25 February 2015

Plasma interleukin-6 levels are increased in subjects with impaired glucose tolerance but not in those with impaired fasting glucose in a cohort of Italian Caucasians

scientific article published in February 2007

Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects

scientific article published in July 2006

Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals

scientific article

Positive association between plasma IGF1 and high-density lipoprotein cholesterol levels in adult nondiabetic subjects.

scientific article published on 31 March 2010

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

scientific article published on May 2003

Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects. Diabetes Care 2008;31:1886-1888

Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance

scientific article published on 23 January 2020

Relative Risk of Cardiovascular Disease Is Higher in Women With Type 2 Diabetes, but Not in Those With Prediabetes, as Compared With Men

scientific article published on 30 September 2020

Renal function predicts cardiovascular outcomes in southern Italian postmenopausal women

scientific article published in August 2009

Response to the Letter: Comment to the letter by Marathe CS, Rayne CK, Jones KL, Horowitz M.

scientific article published in February 2016

SRT1720 counteracts glucosamine-induced endoplasmic reticulum stress and endothelial dysfunction

scientific article published on 2 June 2015

Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials.

scientific article

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

scientific article

TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells

scientific article published on 24 April 2008

TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion

scientific article published in July 2010

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.

scientific article

The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

scientific article

The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals

scientific article

The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes

scientific article published on 4 April 2006

The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism.

scientific article published on 30 July 2016

The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry.

scientific article published on 5 October 2013

The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells

scientific article published on 19 August 2011

The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes

scientific article

The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells

scientific article published on 5 August 2010

The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus

scientific article published on 27 December 2013

The polymorphism rs35767 at IGF1 locus is associated with serum urate levels

scientific article published in Scientific Reports

The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells.

scientific article published on 15 November 2016

The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects

scientific article

Unfavorable inflammatory profile in adults at risk of type 2 diabetes identified by hemoglobin A1c levels according to the American Diabetes Association criteria

scientific article published on 23 September 2014

Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells

scientific article published on 13 April 2017

Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance

scientific article published on 19 August 2020

Usefulness of hemoglobin A1c as a criterion to define the metabolic syndrome in a cohort of italian nondiabetic white subjects

scientific article published on 21 March 2011

Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects

scientific article published on 01 May 2006

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