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List of works by Daniel G Tenen

15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.

scientific article

A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis

scientific article

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma

scientific article

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.

scientific article published in September 2007

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.

scientific article published on 4 December 2003

A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.

scientific article

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.

scientific article

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

scientific article published on April 2001

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

scientific article

Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.

scholarly article

Acute myelogenous leukemia: current treatment and future directions.

scientific article published in March 1992

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

scientific article

Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)

scientific article

An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

scientific article published on August 2005

An alternative method for labeling oligonucleotide probes for screening cDNA libraries.

scientific article

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

article

Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.

scientific article

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

scientific article

Binding of an analog of the simian virus 40 T antigen to wild-type and mutant viral replication origins

scientific article published in May 1982

Binding of simian virus 40 large T antigen from virus-infected monkey cells to wild-type and mutant viral replication origins

scientific article published in August 1983

Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response.

scientific article published on August 2004

Biological and biochemical studies of cells transformed by simian virus 40 temperature-sensitive gene A mutants and A mutant revertants ⬇️

scientific article published on April 1, 1977

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

scientific article

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence ⬇️

scientific article published on March 17, 2013

C/EBPbeta is required for 'emergency' granulopoiesis

scientific article

C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.

scientific article published on November 2003

C/EBP  and DEK coordinately regulate myeloid differentiation

scientific article (publication date: 3 April 2012)

C/EBPα Is Required for Proteolytic Cleavage of Cyclin A by Calpain 3 in Myeloid Precursor Cells

scientific article published in Journal of Biological Chemistry

C/EBPα is required for development of dendritic cell progenitors.

scientific article published on April 2013

C/EBPα mutations in lung cancer

scientific article published on 12 June 2006

C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations

scientific article

C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion.

scientific article published on 5 September 2012

C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia

C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.

scientific article

CCAAT/Enhancer Binding Protein α Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors ⬇️

scientific article published on July 1, 1998

CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

scientific article

CD34 expression by mast cells: of mice and men

scientific article published on 01 September 2005

CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis

scientific article

Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization

scientific article

Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

scientific article

Characterization of a distinct binding site for the prokaryotic chaperone, GroEL, on a human granulocyte ribonuclease.

scientific article published in February 1993

Characterization of the myeloid-specific CD11b promoter.

scientific article published on February 1992

Chromosome 1 localization of the gene for CD34, a surface antigen of human stem cells

scientific article published in January 1990

Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression

scientific article

Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β

scientific article

DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival ⬇️

scientific article (publication date: 2 September 2011)

DNMT1-interacting RNAs block gene-specific DNA methylation

scientific article published on 09 October 2013

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation

scientific article published on 01 February 2007

Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B ⬇️

scientific article published on December 1, 1997

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

scientific article

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

scientific article

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

scientific article published on August 2005

Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.

scientific article

Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations.

scientific article

Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.

scientific article

Distal elements are critical for human CD34 expression in vivo.

scientific article

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.

scientific article

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

scientific article

Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.

scientific article published on February 2007

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

scientific article

Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line

scientific article published on 14 June 2006

Down-regulation and antiproliferative role of C/EBPalpha in lung cancer

scientific article published on 01 January 2002

Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.

scientific article published on June 2007

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

scientific article

Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation

scientific article published in April 2003

Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment

scientific article

Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors

scientific article published on 10 October 2013

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

scientific article

Effect of a stem-loop structure within the SV40 replication origin upon SV40 T antigen binding to origin region sequences

scientific article published in September 1983

Effect of transcription-factor concentrations on leukemic stem cells.

scientific article published on 24 May 2005

Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML

scientific article

Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction

scientific article

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

scientific article published in March 1997

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

scientific journal article

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells

scientific article published on 15 October 2006

Ethnic differences in survival outcome in patients with advanced stage non-small cell lung cancer: results of a meta-analysis of randomized controlled trials.

scientific article published on June 2011

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer

scientific article published on 15 February 2018

Formation of a cruciform structure at the simian virus 40 replication origin abolishes T-antigen binding to the origin in vitro.

scientific article published on October 1985

Functional characterization of the promoter for the gene encoding murine CD34

article

Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

scientific article published on 03 September 2006

Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1.

scientific article published on January 1996

Heterozygous PU.1 mutations are associated with acute myeloid leukemia

scientific article published in August 2002

Heterozygous PU.1 mutations are associated with acute myeloid leukemia

scientific article published on 01 March 2003

Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors

scientific article published on 10 May 2019

Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene

scientific article

Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c.

scientific article published on December 1995

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

scientific article

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

scientific article published on December 1994

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

scientific article published on 14 April 2021

Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites ⬇️

scientific article published on August 1, 1976

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

scientific article

Induced pluripotent stem cells in hematology: current and future applications

scientific article

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

scientific article published on 26 August 2004

Induction of granulocytic differentiation by 2 pathways

scientific article (publication date: 15 June 2002)

Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules ⬇️

scientific article published on May 1, 1975

Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and [...]

scientific article (publication date: May 1992)

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

scientific article published on 27 November 2005

Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465)

scientific article published on 28 June 2019

Metabolic alterations mediated by STAT3 promotes drug persistence in CML

scientific article published on 12 June 2021

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

article

Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells ⬇️

scientific article published on January 1, 1992

Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins

scientific article

Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family

scientific article

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1 ⬇️

scientific article published on July 1, 1998

Multiple control elements are required for expression of the human CD34 gene.

scientific article published on November 1998

Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia.

scientific article published on May 2006

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.

scientific article published on 15 August 2006

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.

scientific article published on 5 August 2014

NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML

scientific article

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B.

scientific article published on May 1995

Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

scientific article published on 11 April 2022

Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.

scientific article

Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

article

Oncofetal gene SALL4 in aggressive hepatocellular carcinoma

scientific article

Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene

scientific article published on November 1, 1991

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

scientific article

PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

scientific article published in December 1995

PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.

scientific article published on October 1995

PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.

scientific article

PU.1 (Spi-1) autoregulates its expression in myeloid cells

scientific journal article

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

scientific article published on August 2008

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.

scientific article published on 26 December 2013

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

scientific article published in 2022

PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2

scientific article

Patients with Cancer Appear More Vulnerable to SARS-COV-2: A Multicenter Study during the COVID-19 Outbreak

scientific article published on 28 April 2020

Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor.

scientific article published on 11 February 2008

Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes

scientific article published on 11 April 2008

Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers

scientific article published on 3 July 2007

Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators

scientific article published on 11 March 2004

Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.

scientific article

Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin

scientific article published on 01 June 1989

Purification of simian virus 40 tumor antigen from a line of simian virus 40-transformed human cells ⬇️

scientific article published on September 1, 1977

RNA editome imbalance in hepatocellular carcinoma.

scientific article published on 20 February 2014

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

scientific article

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

scientific article

Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.

scientific article

Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties.

scientific article

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma ⬇️

scientific article published on 06 January 2013

Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.

scientific article published on October 1994

Regulation of the PU.1 gene by distal elements

article

Regulation of the gene for CD34, a human hematopoietic stem cell antigen, in KG-1 cells.

scientific article published on June 1990

Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.

scientific article

Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

scientific article published in January 2000

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

scientific article

Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice

scientific article

SALL4 is a key transcription regulator in normal human hematopoiesis ⬇️

scientific article published on August 31, 2012

SALL4 is a new target in endometrial cancer

scientific article

Secreted phosphoproteins associated with neoplastic transformation: close homology with plasma proteins cleaved during blood coagulation.

scientific article published in October 1988

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

scientific article

Sp1 is a critical factor for the monocytic specific expression of human CD14.

scientific article published on April 1994

Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution

scientific article published in January 1993

Structure of the gene encoding CD34, a human hematopoietic stem cell antigen

scientific article published on April 1, 1992

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα

scientific article published on 03 August 2018

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

scientific article published on 8 February 2013

T antigen repression of SV40 early transcription from two promoters ⬇️

scientific article published on December 1, 1981

Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9.

scientific article published in August 2007

Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.

scientific article

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

scientific article

The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.

scientific article

The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.

scientific article published on 4 September 2007

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

scientific article

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells

scientific article published on 17 July 2003

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

scientific article published on 24 April 2018

The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.

scientific article published on February 1996

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner

scientific article

The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors

scientific article

The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis

The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture ⬇️

scientific article published on December 15, 1992

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

scientific article published on 29 August 2002

The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro ⬇️

scientific article published on November 15, 1995

The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.

scientific article

Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40 ⬇️

scientific article published on November 1, 1975

Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice

scientific article published in September 2006

Transcription factors in myeloid development: balancing differentiation with transformation.

scientific article

Transcription factors, normal myeloid development, and leukemia ⬇️

scientific article published on July 15, 1997

Transgenic targeting with regulatory elements of the human CD34 gene

scientific article

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

scientific article

Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor ⬇️

scientific article published on January 30, 1998

Unusual cases in multiple myeloma and a dramatic response in metastatic lung cancer: case 4. Mutation of the epidermal growth factor receptor in an elderly man with advanced, gefitinib-responsive, non-small-cell lung cancer

scientific article published in January 2005

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis ⬇️

scientific article published on September 21, 1998

Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBP ⬇️

scientific article published on June 15, 1998

Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences

scientific article

ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function

scientific article published on 04 January 2021

c-Jun is a JNK-independent coactivator of the PU.1 transcription factor.

scientific article

c-Myc is a critical target for c/EBPalpha in granulopoiesis.

scientific article

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