List of works - Jorge Gonçalves

A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and betagamma subunits formed after alpha2-adrenoceptor activation.

scientific article published on 5 April 2007

ATP modulates noradrenaline release by activation of inhibitory P2Y receptors and facilitatory P2X receptors in the rat vas deferens.

scientific article published on 9 September 2003

Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature.

scientific article

Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery

scientific article published in November 2004

Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay

scientific article

Comparison of corelease of noradrenaline and ATP evoked by hypogastric nerve stimulation and field stimulation in guinea-pig vas deferens.

scientific article

Differential inhibition of noradrenaline release mediated by inhibitory A1-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats

scientific article published on 13 February 2013

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system

scientific article published on 17 October 2009

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

scientific article published on 18 January 2018

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms

scientific article published in May 2011

Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect

article

Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery

scientific article

Facilitatory and inhibitory modulation by endogenous adenosine of noradrenaline release in the epididymal portion of rat vas deferens

scientific article published on 01 October 1993

Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue

scientific article published in May 1995

Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein

scientific article published on 27 November 2010

Immunohistochemical characterization of adenosine receptors in rat aorta and tail arteries.

scientific article published in October 2008

Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats

scientific article published on 01 August 2007

Impaired inhibitory function of presynaptic A1-adenosine receptors in SHR mesenteric arteries.

scientific article published in January 2013

In situ mitochondrial Ca2+ buffering differences of intact neurons and astrocytes from cortex and striatum.

scientific article published on 22 December 2008

Influence of neuronal uptake on pre- and postjunctional effects of ?-adrenoceptor agonists in tissues with noradrenaline ? ATP cotransmission ⬇️

scientific article published on November 1, 1991

Inhibition of neural ATP release by atrial natriuretic peptide in guinea-pig vas deferens.

scientific article

Inhibition of protein kinase C by synthetic xanthone derivatives.

scientific article published in April 2003

Interaction between adenosine A 2B-receptors and alpha2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: possible involvement of a group 2 adenylyl cyclase isoform

scientific article published in November 2005

Involvement of G-protein βγ subunits on the influence of inhibitory α2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens

scientific article published on 07 September 2006

Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta

scientific article published in December 2003

Ligands and therapeutic perspectives of adenosine A(2A) receptors

scientific article

Loss of selectivity of so-called selective alpha 1-adrenoceptor agonists after phenoxybenzamine

scientific article published on 01 September 1988

Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors.

scientific article

Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis

scientific article

Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice

scientific article

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

scientific article

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα

scientific article published on 21 December 2010

Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved.

scientific article

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

scientific article published on 28 December 2015

Regional differences in extracellular purine degradation in the prostatic and epididymal portions of the rat vas deferens

scientific article published in September 2005

Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).

scientific article published on 3 May 2009

Semiautomated computer-assisted image analysis to quantify 3,3'-diaminobenzidine tetrahydrochloride-immunostained small tissues

scientific article

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms

scientific article published on 11 July 2006

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

scientific article published in October 2002

Taurine release in the rat vas deferens is modulated by Ca2+ and is independent of contractions

scientific article published on 01 July 1999

The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues

scientific journal article

The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities.

scientific article published on January 2011

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

scientific article

Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations

scientific article published on 01 July 2018

β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells

scientific article published on 27 October 2020

List of works by Jorge Gonçalves

A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and betagamma subunits formed after alpha2-adrenoceptor activation.

ATP modulates noradrenaline release by activation of inhibitory P2Y receptors and facilitatory P2X receptors in the rat vas deferens.

Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature.

Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery

Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay

Comparison of corelease of noradrenaline and ATP evoked by hypogastric nerve stimulation and field stimulation in guinea-pig vas deferens.

Differential inhibition of noradrenaline release mediated by inhibitory A1-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms

Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect

Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery

Facilitatory and inhibitory modulation by endogenous adenosine of noradrenaline release in the epididymal portion of rat vas deferens

Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue

Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein

Immunohistochemical characterization of adenosine receptors in rat aorta and tail arteries.

Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats

Impaired inhibitory function of presynaptic A1-adenosine receptors in SHR mesenteric arteries.

In situ mitochondrial Ca2+ buffering differences of intact neurons and astrocytes from cortex and striatum.

Influence of neuronal uptake on pre- and postjunctional effects of ?-adrenoceptor agonists in tissues with noradrenaline ? ATP cotransmission ⬇️

Inhibition of neural ATP release by atrial natriuretic peptide in guinea-pig vas deferens.

Inhibition of protein kinase C by synthetic xanthone derivatives.

Interaction between adenosine A 2B-receptors and alpha2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: possible involvement of a group 2 adenylyl cyclase isoform

Involvement of G-protein βγ subunits on the influence of inhibitory α2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens

Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta

Ligands and therapeutic perspectives of adenosine A(2A) receptors

Loss of selectivity of so-called selective alpha 1-adrenoceptor agonists after phenoxybenzamine

Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors.

Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis

Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα

Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved.

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

Regional differences in extracellular purine degradation in the prostatic and epididymal portions of the rat vas deferens

Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).

Semiautomated computer-assisted image analysis to quantify 3,3'-diaminobenzidine tetrahydrochloride-immunostained small tissues

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

Taurine release in the rat vas deferens is modulated by Ca2+ and is independent of contractions

The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues

The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities.

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

Vancomycin therapeutic drug monitoring and population pharmacokinetic models in special patient subpopulations

β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells