List of works - Lucília Saraiva

A simple linearization method unveils hidden enzymatic assay interferences

scientific article published on 29 May 2019

A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.

scientific article published on 23 March 2015

A yeast model of the Parkinson's disease-associated protein Parkin

scientific article published on 26 February 2015

Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones ⬇️

scientific article published on 23 May 2020

Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells ⬇️

scientific article published on 6 September 2022

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

scientific article published on 05 March 2011

BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer

scientific article published on 11 June 2021

BRCA1/P53: Two strengths in cancer chemoprevention

scientific article published on 07 January 2020

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

scientific article published on 21 September 2020

Celosia trigyna Linn (Cucurbitaceae) Annihilate Human Breast, Colon, and Lung Cancer Cells: Combination of Cheap Template for Anticancer Screening ⬇️

scientific article published on 30 November 2022

Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay

scientific article

Chronological aging in conidia of pathogenic Aspergillus: Comparison between species

scientific article published on 2 September 2015

Contribution of yeast and plant research for improving human health.

scientific article published on 17 July 2012

Cytotoxic Activity of Royleanone Diterpenes from Benth

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

scientific article

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies

scientific article published on 27 February 2020

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system

scientific article published on 17 October 2009

Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach ⬇️

scientific article published on February 18, 2013

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

scientific article published on 18 January 2018

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms

scientific article published in May 2011

Endocytosis inhibition during H2O2-induced apoptosis in yeast

scientific article published on 23 July 2012

Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.

scientific article published on 14 October 2015

Hydrogen peroxide-induced secondary necrosis in conidia of Aspergillus fumigatus.

scientific article published on 17 November 2015

Improving anticancer activity towards colon cancer cells with a new p53-activating agent

scientific article published on 06 September 2018

Inhibition of protein kinase C by synthetic xanthone derivatives.

scientific article published in April 2003

Interference of aging media on the assessment of yeast chronological life span by propidium iodide staining

scientific article published on 25 July 2012

Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta

scientific article published in December 2003

LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model

scientific article

Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against Candida albicans and Candida krusei

scientific article published in 2021

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.

scientific article published on 15 June 2016

Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis

scientific article

Mitochondria-dependent apoptosis in yeast

scientific article published on 25 March 2008

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα

scientific article published on 21 December 2010

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

scientific article published on 31 December 2018

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

scientific article published on 19 January 2019

New insights into cancer‐related proteins provided by the yeast model ⬇️

scientific article published on February 10, 2012

New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems.

scientific article published on January 2012

Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity

scientific article published on 30 March 2020

Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.

scientific article

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.

scientific article published on 13 October 2014

P53 in skin cancer: From a master player to a privileged target for prevention and therapy

scientific article published on 24 September 2020

Parvifloron D from Plectranthus strigosus: Cytotoxicity Screening of Plectranthus spp. Extracts

scientific article published on 17 October 2019

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays

scientific article published on 04 January 2014

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

scientific article published in 2021

Production and purification of theVP1 capsid protein of a novel canine norovirus using the Saccharomyces cerevisiae expression system

article

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

scientific article published on 28 December 2015

SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner

scientific article published on 17 January 2020

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

scientific article published on 16 September 2019

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

scientific article published on 10 August 2019

SNaPaer: a practical single nucleotide polymorphism multiplex assay for genotyping of Pseudomonas aeruginosa

scientific article

Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).

scientific article published on 3 May 2009

Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment

scientific article published on 01 January 2019

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms

scientific article published on 11 July 2006

Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.

scientific article published on 28 September 2014

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

scientific article published in October 2002

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

scientific article published on 22 May 2019

Targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of Parkinson's disease

scientific article published on 01 August 2019

Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity

scientific article published on 17 July 2018

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

scientific article published on 13 April 2018

The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities.

scientific article published on January 2011

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

scientific article

Yeast As a Chassis for Developing Functional Assays to Study Human P53

scientific article published on 04 August 2019

Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms.

scientific article published on January 2012

p53 and glucose metabolism: an orchestra to be directed in cancer therapy

scientific article published on 23 March 2018

p53 family interactions and yeast: together in anticancer therapy.

scientific article published on 15 February 2016

Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.

scientific article published on 29 March 2013

List of works by Lucília Saraiva

A simple linearization method unveils hidden enzymatic assay interferences

A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.

A yeast model of the Parkinson's disease-associated protein Parkin

Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones ⬇️

Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells ⬇️

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer

BRCA1/P53: Two strengths in cancer chemoprevention

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

Celosia trigyna Linn (Cucurbitaceae) Annihilate Human Breast, Colon, and Lung Cancer Cells: Combination of Cheap Template for Anticancer Screening ⬇️

Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay

Chronological aging in conidia of pathogenic Aspergillus: Comparison between species

Contribution of yeast and plant research for improving human health.

Cytotoxic Activity of Royleanone Diterpenes from Benth

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Diarylpentanoids with antitumor activity: A critical review of structure-activity relationship studies

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system

Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach ⬇️

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms

Endocytosis inhibition during H2O2-induced apoptosis in yeast

Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.

Hydrogen peroxide-induced secondary necrosis in conidia of Aspergillus fumigatus.

Improving anticancer activity towards colon cancer cells with a new p53-activating agent

Inhibition of protein kinase C by synthetic xanthone derivatives.

Interference of aging media on the assessment of yeast chronological life span by propidium iodide staining

Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta

LRRK2, but not pathogenic mutants, protects against H2O2 stress depending on mitochondrial function and endocytosis in a yeast model

Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against Candida albicans and Candida krusei

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.

Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis

Mitochondria-dependent apoptosis in yeast

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

New insights into cancer‐related proteins provided by the yeast model ⬇️

New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems.

Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity

Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.

Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.

P53 in skin cancer: From a master player to a privileged target for prevention and therapy

Parvifloron D from Plectranthus strigosus: Cytotoxicity Screening of Plectranthus spp. Extracts

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

Production and purification of theVP1 capsid protein of a novel canine norovirus using the Saccharomyces cerevisiae expression system

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

SNaPaer: a practical single nucleotide polymorphism multiplex assay for genotyping of Pseudomonas aeruginosa

Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U).

Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms

Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

Targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of Parkinson's disease

Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities.

Using yeast to uncover the regulation of protein kinase Cδ by ceramide.

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms.

p53 and glucose metabolism: an orchestra to be directed in cancer therapy

p53 family interactions and yeast: together in anticancer therapy.

Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.