List of works - Peter T. Simpson

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

scientific article

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

scientific article published on 23 January 2017

Aberrant Expression of E-cadherin in Lobular Carcinomas of the Breast

scientific article published on 01 May 2008

An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomas.

scientific article published on 29 October 2015

Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges

scientific article published on 24 November 2010

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

scientific article published on 26 September 2016

Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study

Breast pathology: beyond morphology

scientific article

Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer.

scientific article

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

scientific article published on 21 February 2018

Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis

scientific article

Complex-based analysis of dysregulated cellular processes in cancer

scientific article

Corrigendum to "Molecular signatures in breast cancer" [Methods 131 (2017) 135-146].

scientific article published on 2 February 2018

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

scientific article

Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks

scientific article published on 07 February 2019

Digital spatial profiling application in breast cancer: a user's perspective

scientific article published on 26 May 2020

Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue

scientific article published in March 2004

EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

article

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

scientific article published on 02 May 2022

Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis

scientific article

Examination of tumour histopathology and gene expression in a neu/S100A4 transgenic model of metastatic breast cancer

scientific article published on 01 August 2003

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

scientific article

Expression of MAGE-A and NY-ESO-1 cancer-testis antigens is enriched in triple-negative invasive breast cancers

scientific article published on 21 February 2018

Expression profiling of archival tumors for long-term health studies

scientific article

FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

scientific article published on November 2006

Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay

scientific article

Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression

article

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

scientific article

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

scientific article

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

scientific article published on 13 March 2017

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

scientific article

In situ carcinoma - can we predict which patient will come back with a recurrence?

scientific article published on 01 November 2007

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity.

scientific article

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

scientific article published on 14 July 2015

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer

scientific article

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

LobSig is a multigene predictor of outcome in invasive lobular carcinoma

scientific article published on 27 June 2019

Mammographic and ultrasound features of invasive lobular carcinoma of the breast

scientific article published on 5 June 2013

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.

scientific article

Metastatic progression of breast cancer: insights from 50 years of autopsies.

scientific article

MicroRNA-182-5p targets a network of genes involved in DNA repair

scientific article

Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology

scientific article published on 18 January 2018

Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis.

scientific article published on 25 November 2008

Molecular aspects of breast cancer metastasis to the brain

scientific article published on 29 November 2011

Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma.

scientific article published on April 2009

Molecular evolution of breast cancer

scientific article

Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas

scientific article published in July 2008

Molecular signatures in breast cancer.

scientific article published on 29 June 2017

Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer

scientific article published on 31 March 2020

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

scientific article

Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers

scientific article published on 01 November 2018

Next-Generation Sequencing of Endobronchial Ultrasound Transbronchial Needle Aspiration Specimens in Lung Cancer.

scientific article published in August 2017

Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancer.

scientific article published in December 2015

P63-driven nuclear accumulation of beta-catenin is not a frequent event in human neoplasms

scientific article published in January 2003

Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.

scientific article published on 26 September 2015

Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications

Phenotypic drift in metastatic progression of breast cancer: A case report with histologically heterogeneous lesions that are clonally related

scientific article published on 27 August 2020

Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact.

scientific article published on March 2009

Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant

scientific article

Profiling copy number alterations in cell-free tumour DNA using a single-reference

Report on emerging technologies for translational bioinformatics: a symposium on gene expression profiling for archival tissues

scientific article published on 29 March 2012

Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer

scientific article

Subtypes of familial breast tumours revealed by expression and copy number profiling

scientific article

TGFβ isoforms and receptors mRNA expression in breast tumours: prognostic value and clinical implications

scientific article published on 24 December 2015

The circular RNome of primary breast cancer

scientific article published on 28 January 2019

The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ

scientific article

The molecular genetics of breast cancer: the contribution of comparative genomic hybridization

scientific article

Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ

scientific article published on 28 June 2018

Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer

scientific article published on 14 August 2013

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

scientific article published on 5 April 2013

Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization

scientific article published on 01 June 2011

Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach

scientific article published on 01 March 2016

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

scientific article published on 13 May 2015

Using whole-genome sequencing data to derive the homologous recombination deficiency scores

scientific article published on 07 August 2020

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

scientific article published on 01 July 2019

cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells

scientific article published on May 2003

miR-139-5p is a regulator of metastatic pathways in breast cancer

scientific article published on 24 October 2013

List of works by Peter T. Simpson

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

Aberrant Expression of E-cadherin in Lobular Carcinomas of the Breast

An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomas.

Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study

Breast pathology: beyond morphology

Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer.

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis

Complex-based analysis of dysregulated cellular processes in cancer

Corrigendum to "Molecular signatures in breast cancer" [Methods 131 (2017) 135-146].

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks

Digital spatial profiling application in breast cancer: a user's perspective

Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue

EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis

Examination of tumour histopathology and gene expression in a neu/S100A4 transgenic model of metastatic breast cancer

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

Expression of MAGE-A and NY-ESO-1 cancer-testis antigens is enriched in triple-negative invasive breast cancers

Expression profiling of archival tumors for long-term health studies

FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay

Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

In situ carcinoma - can we predict which patient will come back with a recurrence?

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity.

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

LobSig is a multigene predictor of outcome in invasive lobular carcinoma

Mammographic and ultrasound features of invasive lobular carcinoma of the breast

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.

Metastatic progression of breast cancer: insights from 50 years of autopsies.

MicroRNA-182-5p targets a network of genes involved in DNA repair

Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology

Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis.

Molecular aspects of breast cancer metastasis to the brain

Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma.

Molecular evolution of breast cancer

Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas

Molecular signatures in breast cancer.

Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers

Next-Generation Sequencing of Endobronchial Ultrasound Transbronchial Needle Aspiration Specimens in Lung Cancer.

Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancer.

P63-driven nuclear accumulation of beta-catenin is not a frequent event in human neoplasms

Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.

Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications

Phenotypic drift in metastatic progression of breast cancer: A case report with histologically heterogeneous lesions that are clonally related

Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact.

Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant

Profiling copy number alterations in cell-free tumour DNA using a single-reference

Report on emerging technologies for translational bioinformatics: a symposium on gene expression profiling for archival tissues

Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer

Subtypes of familial breast tumours revealed by expression and copy number profiling

TGFβ isoforms and receptors mRNA expression in breast tumours: prognostic value and clinical implications

The circular RNome of primary breast cancer

The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ

The molecular genetics of breast cancer: the contribution of comparative genomic hybridization

Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ

Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization

Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

Using whole-genome sequencing data to derive the homologous recombination deficiency scores

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells

miR-139-5p is a regulator of metastatic pathways in breast cancer