List of works - Qiang Chen

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.

scientific article published on 11 January 2018

A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

scientific article

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors

scientific article published on 22 August 2018

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance

scientific article published on 27 November 2017

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode

scientific article published on 29 May 2019

Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

scientific article published on 7 April 2005

Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells

scientific article published in 2022

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

scientific journal article

Cloning, expression and characterization of the hypoxanthine-guanine phosphoribosyltransferase mutants from T. tengcongensis

scientific article published in September 2003

Cloning, purification, and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

scientific article published in December 2003

Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design

scientific article

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

scientific article published on 07 October 2016

Identification of human LDHC4 as a potential target for anticancer drug discovery

scientific article published on 07 December 2021

Mechanism of microtubule stabilization by taccalonolide AJ.

scientific article

N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors

scientific article

Parallel cloning, expression, purification and crystallization of human proteins for structural genomics

scientific article published on 23 November 2002

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

scientific article published on 30 June 2016

Protein preparation, crystallization and preliminary X-ray crystallographic studies of a thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

scientific article published on 19 September 2003

Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain.

scientific article

Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1.

scientific article published on 22 May 2015

Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein

scientific article

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity

scientific article published on 18 October 2019

Soluble expression, purification, and stabilization of a pro-apoptotic human protein, CARP.

scientific article

Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition

scientific article published on 27 May 2016

Structural insights into the design of indole derivatives as tubulin polymerization inhibitors

scientific article published on 16 August 2019

Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design

scientific article published on 29 August 2017

Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design

scientific article published in November 2017

Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamases

scientific article published on 17 July 2019

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

scientific article published on 30 July 2017

Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development

scientific article

The RGD finger of Del-1 is a unique structural feature critical for integrin binding

scientific article

WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

scientific article published in 2022

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells

scientific article published on 19 June 2018

[Production and stabilization of an integrin-binding moiety of complement component 3].

scientific article

List of works by Qiang Chen

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.

A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode

Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

Bi-PE: bi-directional priming improves CRISPR/Cas9 prime editing in mammalian cells

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Cloning, expression and characterization of the hypoxanthine-guanine phosphoribosyltransferase mutants from T. tengcongensis

Cloning, purification, and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Identification of human LDHC4 as a potential target for anticancer drug discovery

Mechanism of microtubule stabilization by taccalonolide AJ.

N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors

Parallel cloning, expression, purification and crystallization of human proteins for structural genomics

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

Protein preparation, crystallization and preliminary X-ray crystallographic studies of a thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis

Protein production, crystallization and preliminary X-ray analysis of two isoforms of the Dscam1 Ig7 domain.

Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1.

Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity

Soluble expression, purification, and stabilization of a pro-apoptotic human protein, CARP.

Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition

Structural insights into the design of indole derivatives as tubulin polymerization inhibitors

Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design

Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design

Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamases

Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.

Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development

The RGD finger of Del-1 is a unique structural feature critical for integrin binding

WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells

[Production and stabilization of an integrin-binding moiety of complement component 3].