List of works - Charles S Hoffman

A Brief History of Schizosaccharomyces pombe Research: A Perspective Over the Past 70 Years

scientific article

A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening

scientific article published on 24 April 2019

A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases ⬇️

scientific article published on April 15, 1991

A frameshift mutation at the junction of an IS1 insertion within lacZ restores beta-galactosidase activity via formation of an active lacZ-IS1 fusion protein

scientific article published in February 1985

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli

scientific article (publication date: 1987)

A transcriptionally regulated expression vector for the fission yeast Schizosaccharomyces pombe

scientific article published on 01 December 1989

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

scientific article (publication date: 2013)

A yeast-based high-throughput screen for modulators of phosphodiesterase activity.

scientific article published in January 2015

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

scientific article

An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System

scientific article

Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor

scientific article published on 22 December 2014

Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.

scientific article published on 13 June 2016

Corrigendum. An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.

scientific article published on March 2016

Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases

scientific article

Divergent subunit interactions among fungal mRNA 5'-capping machineries

scientific article

Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe

scientific article (publication date: March 2005)

Fission Yeast Tup1-Like Repressors Repress Chromatin Remodeling at the fbp1+ Promoter and the ade6-M26 Recombination Hotspot ⬇️

scientific article published on October 1, 2003

Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses

scientific article published on 03 February 2004

Fission yeast-based high-throughput screens for PKA pathway inhibitors and activators.

scientific article

Glucose monitoring in fission yeast via the Gpa2 galpha, the git5 Gbeta and the git3 putative glucose receptor

scientific article

Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway

scientific article published on 01 April 1991

Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression

scientific article published on 28 August 2018

Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.

scientific article published in September 2017

Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen

scientific article

Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1

scientific article published on 30 June 2017

Local potentiation of stress-responsive genes by upstream noncoding transcription

scientific article published on 3 March 2016

Mutagenesis and gene cloning in Schizosaccharomyces pombe using nonhomologous plasmid integration and rescue

scientific article published on 01 March 2000

New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

scientific article

Preparation of yeast DNA.

scientific article published in May 2001

Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast

scientific article

Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

scientific article

Propping up our knowledge of G protein signaling pathways: diverse functions of putative noncanonical Gbeta subunits in fungi.

scientific article published on 23 January 2007

Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites.

scientific article

Pseudostructural inhibitors of G protein signaling during development.

scientific article

Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

scientific article published in September 2017

Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators.

scientific article published on April 2008

Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.

scientific article

Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation

scientific article

Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

scientific article

Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

scientific article published on April 2008

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling

scientific article

Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe

scientific article published on 2 December 2013

Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe

scientific article

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

scientific article

Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

scientific article

The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

scientific article published on July 1996

The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis

scientific article published on December 1992

The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation.

scientific article

The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

scientific article published on 27 February 2003

Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex

scientific article

Use of PKA-mediated phenotypes for genetic and small-molecule screens in Schizosaccharomyces pombe

scientific article published on December 2013

Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases

scientific article

Use of a ura5+-lys7+ cassette to construct unmarked gene knock-ins in Schizosaccharomyces pombe

scientific article

lncRNA transcriptional initiation induces chromatin remodeling within a limited range in the fission yeast fbp1 promoter

scientific article published in Scientific Reports

sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.

scientific article

List of works by Charles S Hoffman

A Brief History of Schizosaccharomyces pombe Research: A Perspective Over the Past 70 Years

A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening

A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases ⬇️

A frameshift mutation at the junction of an IS1 insertion within lacZ restores beta-galactosidase activity via formation of an active lacZ-IS1 fusion protein

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli

A transcriptionally regulated expression vector for the fission yeast Schizosaccharomyces pombe

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

A yeast-based high-throughput screen for modulators of phosphodiesterase activity.

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System

Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor

Anti-inflammatory effects of novel barbituric acid derivatives in T lymphocytes.

Corrigendum. An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System.

Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases

Divergent subunit interactions among fungal mRNA 5'-capping machineries

Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe

Fission Yeast Tup1-Like Repressors Repress Chromatin Remodeling at the fbp1+ Promoter and the ade6-M26 Recombination Hotspot ⬇️

Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses

Fission yeast-based high-throughput screens for PKA pathway inhibitors and activators.

Glucose monitoring in fission yeast via the Gpa2 galpha, the git5 Gbeta and the git3 putative glucose receptor

Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway

Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression

Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.

Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen

Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1

Local potentiation of stress-responsive genes by upstream noncoding transcription

Mutagenesis and gene cloning in Schizosaccharomyces pombe using nonhomologous plasmid integration and rescue

New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

Preparation of yeast DNA.

Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast

Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

Propping up our knowledge of G protein signaling pathways: diverse functions of putative noncanonical Gbeta subunits in fungi.

Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites.

Pseudostructural inhibitors of G protein signaling during development.

Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators.

Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.

Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation

Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling

Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe

Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis

The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation.

The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex

Use of PKA-mediated phenotypes for genetic and small-molecule screens in Schizosaccharomyces pombe

Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases

Use of a ura5+-lys7+ cassette to construct unmarked gene knock-ins in Schizosaccharomyces pombe

lncRNA transcriptional initiation induces chromatin remodeling within a limited range in the fission yeast fbp1 promoter

sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.