List of works - Enzo Alessio

1-(2-Picolyl)-substituted 1,2,3-triazole as novel chelating ligand for the preparation of ruthenium complexes with potential anticancer activity

scientific article

15N NMR spectroscopy unambiguously establishes the coordination mode of the diimine linker 2-(2′-pyridyl)pyrimidine-4-carboxylic acid (cppH) in Ru(ii) complexes

A Maltol-Containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent

scientific article published on 17 February 2020

A categorization of metal anticancer compounds based on their mode of action

scientific article published on 05 June 2009

A functionalized noncovalent macrocyclic multiporphyrin assembly from a dizinc(II) bis-porphyrin receptor and a free-base dipyridylporphyrin

scientific article published in December 2003

A novel ruthenium nitrosyl complex which also contains a free NO-donor moiety

A spectroscopic study of the reaction of NAMI, a novel ruthenium(III)anti-neoplastic complex, with bovine serum albumin

scientific article published on 01 February 2000

An irresolute linker: separation, and structural and spectroscopic characterization of the two linkage isomers of a Ru(ii)-(2-(2′-pyridyl)pyrimidine-4-carboxylic acid) complex

article

Anti-leukaemic action of RuCl2 (DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P388/DDP subline

scientific article published in January 1993

Antimetastatic action and toxicity on healthy tissues of Na[trans-RuCl4(DMSO)Im] in the mouse

article

Antimetastatic properties and DNA interactions of the novel class of dimeric Ru(III) compounds Na2[{trans-RuCl4(Me2SO)}2(μ-L)] (L=ditopic, non-chelating aromatic N-ligand). A preliminary investigation

scientific article published on 01 April 2000

Antineoplastic effect of mer-trichlorobisdimethylsulphoxideaminorutheniumIII against murine tumors: comparison with cisplatin and with ImH[RuIm2Cl4].

scientific article

Antitumour properties of dimethylsulphoxide ruthenium(II) complexes in the Lewis lung carcinoma system

scientific article published on 01 September 1989

Concerted motions in supramolecular systems: metal-mediated assemblies of porphyrins that behave like nanometric step-machines

scientific article published on 26 November 2010

DNA as a possible target for antitumor ruthenium(III) complexes

scientific article

Design of photoactivatable metallodrugs: Selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes

article by Giulio Ragazzon et al published December 2012 in Inorganica Chimica Acta

Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines

scientific article published on 11 February 2003

Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex

scientific article published on 01 September 1996

Effects of NAMI-A and some related ruthenium complexes on cell viability after short exposure of tumor cells.

scientific article published in September 2000

Effects of ruthenium complexes on experimental tumors: irrelevance of cytotoxicity for metastasis inhibition

scientific article published on 01 March 1995

Electronic energy transfer in a multiporphyrin-based molecular box

scientific article published on 01 July 2006

Factors that influence the antiproliferative activity of half sandwich Ru(II)-[9]aneS3 coordination compounds: activation kinetics and interaction with guanine derivatives

scientific article published on 17 August 2012

Free exchange across cells, and echistatin-sensitive membrane target for the metastasis inhibitor NAMI-A (imidazolium trans-imidazole dimethyl sulfoxide tetrachlororuthenate) on KB tumor cells.

scientific article

Front Cover: Photolabile Ru Model Complexes with Chelating Diimine Ligands for Light-Triggered Drug Release (Eur. J. Inorg. Chem. 13/2018)

Half-sandwich Ru II[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: preparation, structural characterization and in vitro cytotoxic activity

scientific article published on 9 January 2008

Half-sandwich RuII-[9]aneS3 complexes with dicarboxylate ligands: synthesis, characterization and chemical behavior

In situ NMR characterisation of an intermediate in the catalytic hydrogenation of CO2 and HCO 3 - in aqueous solution

Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A.

scientific article published in February 2002

Influence of the anionic ligands on the anticancer activity of Ru(II)-dmso complexes: Kinetics of aquation and in vitro cytotoxicity of new dicarboxylate compounds in comparison with their chloride precursors

scientific article published on 24 October 2007

Is the Aromatic Fragment of Piano-Stool Ruthenium Compounds an Essential Feature for Anticancer Activity? The Development of New RuII-[9]aneS3 Analogues

article

Metalloporphyrins as chemical shift reagents: the unambiguous NMR characterization of the cis- and trans-isomers of meso-(bis)-4′-pyridyl-(bis)-4′-carboxymethylphenylporphyrins

Modular self-assembled multiporphyrin cages with tunable shape

scientific article published on 19 April 2012

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

scientific article published on 24 May 2019

NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

scientific article

Na[trans-RuCl4(DMSO)Im], a metal complex of ruthenium with antimetastatic properties

scientific article published on 01 July 1992

Neutral 1,3,5-Triaza-7-phosphaadamantane-Ruthenium(II) Complexes as Precursors for the Preparation of Highly Water-Soluble Derivatives

New Insight into a Deceptively Simple Reaction: The Coordination of bpy to RuII-Carbonyl Precursors - The Central Role of thefac-[Ru(bpy)Cl(CO)3]+Intermediate and theChloride ReboundMechanism

New cationic and neutral Ru(II)- and Os(II)-dmso carbonyl compounds

scientific article published on 3 October 2013

New half sandwich Ru(II) coordination compounds for anticancer activity

scientific article published on 11 May 2012

New half sandwich-type Ru(II) coordination compounds characterized by the fac-Ru(dmso-S)3 fragment: influence of the face-capping group on the chemical behavior and in vitro anticancer activity

scientific article

New ruthenium(II) precursors with the tetradentate sulfur macrocycles tetrathiacyclododecane ([12]aneS4) and tetrathiacyclohexadecane ([16]aneS4) for the construction of metal-mediated supramolecular assemblies

New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium

scientific article published on 25 July 2013

New water-soluble ruthenium(II) terpyridine complexes for anticancer activity: synthesis, characterization, activation kinetics, and interaction with guanine derivatives

scientific article

Novel Ru(III)-dimethyl sulfoxide catalysts for the selective oxidation of thioethers to sulfoxides with molecular oxygen

Novel Ruthenium Building Blocks for the Efficient Modular Construction of Heterobimetallic Molecular Squares of Porphyrins

scholarly article by Elisabetta Iengo et al published 17 March 2000 in Angewandte Chemie

Novel Ruthenium Building Blocks for the Efficient Modular Construction of Heterobimetallic Molecular Squares of Porphyrins This work was supported by the Italian MURST. We thank Prof. L. G. Marzilli (Emory University, Atlanta, USA) for helpful discu

scientific article published on 01 March 2000

Novel water-soluble (99m)Tc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging

scientific article

Orthogonal Coordination Chemistry of PTA toward Ru(II) and Zn(II) (PTA = 1,3,5-Triaza-7-phosphaadamantane) for the Construction of 1D and 2D Metal-Mediated Porphyrin Networks

scientific article published on 26 February 2020

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

scientific article published on 25 October 2014

Photolabile Ru Model Complexes with Chelating Diimine Ligands for Light-Triggered Drug Release

Photolabile RuIIHalf-Sandwich Complexes Suitable for Developing “Caged” Compounds: Chemical Investigation and Unexpected Dinuclear Species with Bridging Diamine Ligands

article

Photophysics of pyridylporphyrin Ru(II) adducts: heavy-atom effects and intramolecular decay pathways.

scientific article published in July 2001

Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates

scientific article published on 2 September 2015

Pyridylporphyrin metallacycles with a slipped cofacial geometry: spectroscopic, X-ray, and photophysical characterization

scientific article published in December 2005

Rare Example of Stereoisomeric 2 + 2 Metallacycles of Porphyrins Featuring Chiral-at-Metal Octahedral Ruthenium Corners

scientific article published on 15 May 2019

Reaction of cis-RuII(DMSO)4Cl2 with DNA and with some of its bases in aqueous solution

Replacement of chlorides with dicarboxylate ligands in anticancer active Ru(II)-DMSO compounds: a new strategy that might lead to improved activity

scientific article

Ru(ii)-Peptide bioconjugates with the cppH linker (cppH = 2-(2'-pyridyl)pyrimidine-4-carboxylic acid): synthesis, structural characterization, and different stereochemical features between organic and aqueous solvents

Ruthenium Anticancer Compounds: Challenges and Expectations

scholarly article by Ioannis Bratsos et al published 28 November 2007 in Chimia

Ruthenium and Other Non-Platinum Anticancer Compounds

Ruthenium antimetastatic agents

scientific article

Ruthenium-porphyrin conjugates with cytotoxic and phototoxic antitumor activity

scientific article

Self-assembled metallacycles with pyrazine edges: a new example in which the unexpected molecular triangle prevails over the expected molecular square

scientific article published on 10 November 2007

Solution, solid state and biological characterization of ruthenium(III)-DMSO complexes with purine base derivatives

scientific article

Stepwise assembly of unsymmetrical supramolecular arrays containing porphyrins and coordination compounds

scientific article published on 01 April 2000

Structural and photophysical characterization of multichromophoric pyridylporphyrin-rhenium(i) conjugates.

scientific article

Synthesis and Reactivity of Ru-, Os-, Rh-, and Ir-Halide−Sulfoxide Complexes†

Synthesis and characterization of monochelated carboxylatopalladium(II) complexes with nitrogen-donor chelating ligands. Crystal structures of diacetato(1,10-phenanthroline)- and diacetato(2,9-dimethyl-1,10-phenanthroline)-palladium(II)

scholarly article by Barbara Milani et al published 1994 in Dalton transactions RSC

Synthesis and characterization of new halogen-tetramethylene sulfoxide-ruthenium(II) and ruthenium(III) complexes; crystal structure of cis-dichlorotetrakis(tetramethylene sulfoxide)ruthenium(II) and hydrogen trans-bis(tetramethylene sulfoxide)tetrac

scholarly article by Enzo Alessio et al published November 1990 in Inorganica Chimica Acta

Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1

scientific article published in February 2004

Synthetic strategies and structural aspects of metal-mediated multiporphyrin assemblies

scientific article published on 01 November 2006

Synthetic strategies towards ruthenium-porphyrin conjugates for anticancer activity

scientific article published on 27 August 2009

The NAMI A – human ferritin system: a biophysical characterization

scientific article published on 01 August 2018

The synthesis of RuBr2(DMSO)3 revisited: a mixture of Li[fac-RuClnBr3−n(DMSO)3] isomers (n=0−3) is the reaction product

article published in 1992

The unprecedented bridging coordination mode of 1,1-cyclobutane dicarboxylate (mu-cbdc-O,O') stabilized by intramolecular hydrogen bonds in ruthenium(II) complexes

scientific article

Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

scholarly article by Enzo Alessio published 28 September 2016 in European Journal of Inorganic Chemistry

Towards matched pairs of porphyrin-Re(I) /(99m) Tc(I) conjugates that combine photodynamic activity with fluorescence and radio imaging

scientific article published on 23 February 2014

Trinuclear metallacycles: metallatriangles and much more

scientific article published on 01 December 2008

Understanding the orientation and dynamic motion of planar heterocyclic N-donor ligands by exploiting the symmetry properties of mixed-ligand mu-oxorhenium(V) dinuclear complexes

scientific article published on 01 January 2000

Water-Soluble Ruthenium(II) Carbonyls with 1,3,5-Triaza-7-phosphoadamantane

Water-soluble Ru(II)- and Ru(III)-halide-PTA complexes (PTA=1,3,5-triaza-7-phosphaadamantane): Chemical and biological properties

scientific article published on 16 February 2016

Wavelength-dependent electron and energy transfer pathways in a side-to-face ruthenium porphyrin/perylene bisimide assembly

scientific article

fac-[Re(CO)3(dmso-O)3](CF3SO3): a new versatile and efficient Re(I) precursor for the preparation of mono and polynuclear compounds containing fac-[Re(CO)3]+ fragments

scientific article published on 04 September 2006

List of works by Enzo Alessio

1-(2-Picolyl)-substituted 1,2,3-triazole as novel chelating ligand for the preparation of ruthenium complexes with potential anticancer activity

15N NMR spectroscopy unambiguously establishes the coordination mode of the diimine linker 2-(2′-pyridyl)pyrimidine-4-carboxylic acid (cppH) in Ru(ii) complexes

A Maltol-Containing Ruthenium Polypyridyl Complex as a Potential Anticancer Agent

A categorization of metal anticancer compounds based on their mode of action

A functionalized noncovalent macrocyclic multiporphyrin assembly from a dizinc(II) bis-porphyrin receptor and a free-base dipyridylporphyrin

A novel ruthenium nitrosyl complex which also contains a free NO-donor moiety

A spectroscopic study of the reaction of NAMI, a novel ruthenium(III)anti-neoplastic complex, with bovine serum albumin

An irresolute linker: separation, and structural and spectroscopic characterization of the two linkage isomers of a Ru(ii)-(2-(2′-pyridyl)pyrimidine-4-carboxylic acid) complex

Anti-leukaemic action of RuCl2 (DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P388/DDP subline

Antimetastatic action and toxicity on healthy tissues of Na[trans-RuCl4(DMSO)Im] in the mouse

Antimetastatic properties and DNA interactions of the novel class of dimeric Ru(III) compounds Na2[{trans-RuCl4(Me2SO)}2(μ-L)] (L=ditopic, non-chelating aromatic N-ligand). A preliminary investigation

Antineoplastic effect of mer-trichlorobisdimethylsulphoxideaminorutheniumIII against murine tumors: comparison with cisplatin and with ImH[RuIm2Cl4].

Antitumour properties of dimethylsulphoxide ruthenium(II) complexes in the Lewis lung carcinoma system

Concerted motions in supramolecular systems: metal-mediated assemblies of porphyrins that behave like nanometric step-machines

DNA as a possible target for antitumor ruthenium(III) complexes

Design of photoactivatable metallodrugs: Selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes

Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines

Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex

Effects of NAMI-A and some related ruthenium complexes on cell viability after short exposure of tumor cells.

Effects of ruthenium complexes on experimental tumors: irrelevance of cytotoxicity for metastasis inhibition

Electronic energy transfer in a multiporphyrin-based molecular box

Factors that influence the antiproliferative activity of half sandwich Ru(II)-[9]aneS3 coordination compounds: activation kinetics and interaction with guanine derivatives

Free exchange across cells, and echistatin-sensitive membrane target for the metastasis inhibitor NAMI-A (imidazolium trans-imidazole dimethyl sulfoxide tetrachlororuthenate) on KB tumor cells.

Front Cover: Photolabile Ru Model Complexes with Chelating Diimine Ligands for Light-Triggered Drug Release (Eur. J. Inorg. Chem. 13/2018)

Half-sandwich Ru II[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: preparation, structural characterization and in vitro cytotoxic activity

Half-sandwich RuII-[9]aneS3 complexes with dicarboxylate ligands: synthesis, characterization and chemical behavior

In situ NMR characterisation of an intermediate in the catalytic hydrogenation of CO2 and HCO 3 - in aqueous solution

Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A.

Influence of the anionic ligands on the anticancer activity of Ru(II)-dmso complexes: Kinetics of aquation and in vitro cytotoxicity of new dicarboxylate compounds in comparison with their chloride precursors

Is the Aromatic Fragment of Piano-Stool Ruthenium Compounds an Essential Feature for Anticancer Activity? The Development of New RuII-[9]aneS3 Analogues

Metalloporphyrins as chemical shift reagents: the unambiguous NMR characterization of the cis- and trans-isomers of meso-(bis)-4′-pyridyl-(bis)-4′-carboxymethylphenylporphyrins

Modular self-assembled multiporphyrin cages with tunable shape

NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry

NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

Na[trans-RuCl4(DMSO)Im], a metal complex of ruthenium with antimetastatic properties

Neutral 1,3,5-Triaza-7-phosphaadamantane-Ruthenium(II) Complexes as Precursors for the Preparation of Highly Water-Soluble Derivatives

New Insight into a Deceptively Simple Reaction: The Coordination of bpy to RuII-Carbonyl Precursors - The Central Role of thefac-[Ru(bpy)Cl(CO)3]+Intermediate and theChloride ReboundMechanism

New cationic and neutral Ru(II)- and Os(II)-dmso carbonyl compounds

New half sandwich Ru(II) coordination compounds for anticancer activity

New half sandwich-type Ru(II) coordination compounds characterized by the fac-Ru(dmso-S)3 fragment: influence of the face-capping group on the chemical behavior and in vitro anticancer activity

New ruthenium(II) precursors with the tetradentate sulfur macrocycles tetrathiacyclododecane ([12]aneS4) and tetrathiacyclohexadecane ([16]aneS4) for the construction of metal-mediated supramolecular assemblies

New uses for old drugs: attempts to convert quinolone antibacterials into potential anticancer agents containing ruthenium

New water-soluble ruthenium(II) terpyridine complexes for anticancer activity: synthesis, characterization, activation kinetics, and interaction with guanine derivatives

Novel Ru(III)-dimethyl sulfoxide catalysts for the selective oxidation of thioethers to sulfoxides with molecular oxygen

Novel Ruthenium Building Blocks for the Efficient Modular Construction of Heterobimetallic Molecular Squares of Porphyrins

Novel Ruthenium Building Blocks for the Efficient Modular Construction of Heterobimetallic Molecular Squares of Porphyrins This work was supported by the Italian MURST. We thank Prof. L. G. Marzilli (Emory University, Atlanta, USA) for helpful discu

Novel water-soluble (99m)Tc(I)/Re(I)-porphyrin conjugates as potential multimodal agents for molecular imaging

Orthogonal Coordination Chemistry of PTA toward Ru(II) and Zn(II) (PTA = 1,3,5-Triaza-7-phosphaadamantane) for the Construction of 1D and 2D Metal-Mediated Porphyrin Networks

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

Photolabile Ru Model Complexes with Chelating Diimine Ligands for Light-Triggered Drug Release

Photolabile Ru Model Complexes with Chelating Diimine Ligands for Light-Triggered Drug Release

Photolabile RuIIHalf-Sandwich Complexes Suitable for Developing “Caged” Compounds: Chemical Investigation and Unexpected Dinuclear Species with Bridging Diamine Ligands

Photophysics of pyridylporphyrin Ru(II) adducts: heavy-atom effects and intramolecular decay pathways.

Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates

Pyridylporphyrin metallacycles with a slipped cofacial geometry: spectroscopic, X-ray, and photophysical characterization

Rare Example of Stereoisomeric 2 + 2 Metallacycles of Porphyrins Featuring Chiral-at-Metal Octahedral Ruthenium Corners

Reaction of cis-RuII(DMSO)4Cl2 with DNA and with some of its bases in aqueous solution

Replacement of chlorides with dicarboxylate ligands in anticancer active Ru(II)-DMSO compounds: a new strategy that might lead to improved activity

Ru(ii)-Peptide bioconjugates with the cppH linker (cppH = 2-(2'-pyridyl)pyrimidine-4-carboxylic acid): synthesis, structural characterization, and different stereochemical features between organic and aqueous solvents

Ruthenium Anticancer Compounds: Challenges and Expectations

Ruthenium and Other Non-Platinum Anticancer Compounds

Ruthenium antimetastatic agents

Ruthenium-porphyrin conjugates with cytotoxic and phototoxic antitumor activity

Self-assembled metallacycles with pyrazine edges: a new example in which the unexpected molecular triangle prevails over the expected molecular square

Solution, solid state and biological characterization of ruthenium(III)-DMSO complexes with purine base derivatives

Stepwise assembly of unsymmetrical supramolecular arrays containing porphyrins and coordination compounds

Structural and photophysical characterization of multichromophoric pyridylporphyrin-rhenium(i) conjugates.

Synthesis and Reactivity of Ru-, Os-, Rh-, and Ir-Halide−Sulfoxide Complexes†

Synthesis and characterization of monochelated carboxylatopalladium(II) complexes with nitrogen-donor chelating ligands. Crystal structures of diacetato(1,10-phenanthroline)- and diacetato(2,9-dimethyl-1,10-phenanthroline)-palladium(II)

Synthesis and characterization of new halogen-tetramethylene sulfoxide-ruthenium(II) and ruthenium(III) complexes; crystal structure of cis-dichlorotetrakis(tetramethylene sulfoxide)ruthenium(II) and hydrogen trans-bis(tetramethylene sulfoxide)tetrac

Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1

Synthetic strategies and structural aspects of metal-mediated multiporphyrin assemblies

Synthetic strategies towards ruthenium-porphyrin conjugates for anticancer activity

The NAMI A – human ferritin system: a biophysical characterization

The synthesis of RuBr2(DMSO)3 revisited: a mixture of Li[fac-RuClnBr3−n(DMSO)3] isomers (n=0−3) is the reaction product

The unprecedented bridging coordination mode of 1,1-cyclobutane dicarboxylate (mu-cbdc-O,O') stabilized by intramolecular hydrogen bonds in ruthenium(II) complexes

Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

Towards matched pairs of porphyrin-Re(I) /(99m) Tc(I) conjugates that combine photodynamic activity with fluorescence and radio imaging

Trinuclear metallacycles: metallatriangles and much more