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List of works by Jacky Y. Suen

A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling.

scientific article

A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells.

scientific article published on 20 December 2017

Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance

scientific article published on 05 April 2018

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats ⬇️

scientific article published on September 1, 2012

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

scientific article published on 30 March 2012

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

scientific article published on 25 October 2011

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

scientific article published on 17 December 2015

Biased Signaling by Agonists of Protease Activated Receptor 2.

scientific article published on 7 February 2017

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

scientific article published on March 2014

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

scientific article

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

scientific article

Differential immunological profiles herald magnetic resonance imaging-defined perioperative cerebral infarction.

scientific article

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

scientific article

Effect of ex vivo extracorporeal membrane oxygenation flow dynamics on immune response

scientific article published on 01 April 2019

Endothelialized flow models for blood transfusion research

scientific article published on 14 February 2019

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

scientific article published on 24 August 2017

Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

scientific article published on 25 March 2019

Hurdles to Cardioprotection in the Critically Ill

scientific article published on 05 August 2019

Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock

scientific article published on 22 November 2018

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

scientific article published on 16 September 2013

Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit

scientific article published on 20 August 2019

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

scientific article

Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation

scientific article published on 01 April 2019

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

scientific article

Neuron-Specific Enolase and Matrix Metalloproteinase 9 Signal Perioperative Silent Brain Infarction During or After Transcatheter Aortic Valve Implantation

scientific article published on 06 November 2018

Novel Agonists and Antagonists for Human Protease Activated Receptor 2 ⬇️

scientific article published on October 28, 2010

PAR2 Modulators Derived from GB88.

scientific article

Pathway-selective antagonism of proteinase activated receptor 2.

scientific article

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis

scientific article published on 25 March 2019

Potent Small Agonists of Protease Activated Receptor 2.

scientific article published on 30 November 2015

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

scientific article published on 23 October 2015

Pre-clinical study protocol: Blood transfusion in endotoxaemic shock

scientific article published on 09 May 2019

Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells

scientific article

Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney

scientific article published on 31 July 2019

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

scientific article

Recruitment manoeuvres dislodge mucus towards the distal airways in an experimental model of severe pneumonia

scientific article published on 10 November 2018

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

scientific article published on 7 October 2015

Resuscitation Associated Endotheliopathy (PubMed).

scientific article published in 2023

Structure, function and pathophysiology of protease activated receptors.

scientific article published on 26 January 2011

Transcriptomic profiling of cardiac tissues from <scp>SARS‐CoV</scp>‐2 patients identifies <scp>DNA</scp> damage

scientific article published in 2022

Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials

scientific article published on 24 May 2018

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